scholarly journals Opsonization but not pretreatment of equine macrophages with hyperimmune plasma nonspecifically enhances phagocytosis and intracellular killing of Rhodococcus equi

2020 ◽  
Author(s):  
Aja B. Harvey ◽  
Angela I. Bordin ◽  
Joana N. Rocha ◽  
Jocelyn M. Bray ◽  
Noah D. Cohen
Keyword(s):  
Rhodococcus Equi ◽  
Intracellular Killing

scholarly journals Cooperation between Reactive Oxygen and Nitrogen Intermediates in Killing of Rhodococcus equi by Activated Macrophages

2000 ◽  
Vol 68 (6) ◽  
pp. 3587-3593 ◽  
Author(s):  
Patricia A. Darrah ◽  
Mary K. Hondalus ◽  
Quiping Chen ◽  
Harry Ischiropoulos ◽  
David M. Mosser
Keyword(s):  
Nitric Oxide ◽  
Prolonged Exposure ◽  
Rhodococcus Equi ◽  
Activated Macrophages ◽  
Intracellular Killing ◽  
Oxygen Intermediates ◽  
Bacterial Killing ◽  
Ifn Γ

ABSTRACT Rhodococcus equi is a facultative intracellular bacterium of macrophages which can infect immunocompromised humans and young horses. In the present study, we examine the mechanism of host defense against R. equi by using a murine model. We show that bacterial killing is dependent upon the presence of gamma interferon (IFN-γ), which activates macrophages to produce reactive nitrogen and oxygen intermediates. These two radicals combine to form peroxynitrite (ONOO−), which kills R. equi. Mice deficient in the production of either the high-output nitric oxide pathway (iNOS−/−) or the oxidative burst (gp91 phox−/− ) are more susceptible to lethalR. equi infection and display higher bacterial burdens in their livers, spleens, and lungs than wild-type mice. These in vivo observations, which implicate both nitric oxide (NO) and superoxide (O2 −) in bacterial killing, were reexamined in cell-free radical-generating assays. In these assays, R. equi remains fully viable following prolonged exposure to high concentrations of either nitric oxide or superoxide, indicating that neither compound is sufficient to mediate bacterial killing. In contrast, brief exposure of bacteria to ONOO− efficiently kills virulent R. equi. The intracellular killing of bacteria in vitro by activated macrophages correlated with the production of ONOO− in situ. Inhibition of nitric oxide production by activated macrophages by usingN G-monomethyl-l-arginine blocks their production of ONOO− and weakens their ability to control rhodococcal replication. These studies indicate that peroxynitrite mediates the intracellular killing of R. equiby IFN-γ-activated macrophages.

Die Früherkennung der Rhodococcus-equi-Pneumonie beim Fohlen durch Einsatz der Sonographie

Pneumologie ◽  
2004 ◽  
Vol 58 (S 1) ◽  
Author(s):  
O Althaus ◽  
M Venner
Keyword(s):  
Rhodococcus Equi

Exemplar Abstract for Rhodococcus equi (Magnusson 1923) Goodfellow and Alderson 1977 (Approved Lists 1980) emend. Nouioui et al. 2018.

2003 ◽  
Author(s):  
Charles Thomas Parker ◽  
Dorothea Taylor ◽  
George M Garrity
Keyword(s):  
Rhodococcus Equi

Plasma lipidome of healthy and Rhodococcus equi ‐infected foals over time

2021 ◽  
Author(s):  
Jorge L. Sanclemente ◽  
Sol Maiam Rivera‐Velez ◽  
Nairanjana Dasgupta ◽  
David W. Horohov ◽  
Paul L. Wood ◽  
...  
Keyword(s):  
Rhodococcus Equi ◽  
Over Time

Humoral Antibody Response to the Antigens of Virulent Rhodococcus equi in Foals.

1994 ◽  
Vol 5 (4) ◽  
pp. 121-126 ◽  
Author(s):  
Shinji TAKAI ◽  
Hisashi KITAJIMA ◽  
Yoshihiro TAMADA ◽  
Susumu MATSUKURA ◽  
Yasuo OHWA ◽  
...  
Keyword(s):  
Antibody Response ◽  
Rhodococcus Equi ◽  
Humoral Antibody

Defective intracellular killing of micro-organisms by murine alveolar macrophages

1989 ◽  
Vol 26 (1-2) ◽  
pp. 206-207 ◽  
Author(s):  
P. H. Nibbering ◽  
M. T. Barselaar ◽  
J. S. Gevel ◽  
R. Furth
Keyword(s):  
Alveolar Macrophages ◽  
Intracellular Killing ◽  
Micro Organisms

Intracellular killing of Trichophyton mentagrophytes microconidia by normal human polymorphonuclear leukocytes

1985 ◽  
Vol 278 (1) ◽  
pp. 77-78 ◽  
Author(s):  
H. Hauck ◽  
M. Skořepová ◽  
M. Simon ◽  
D. Djawari
Keyword(s):  
Polymorphonuclear Leukocytes ◽  
Trichophyton Mentagrophytes ◽  
Intracellular Killing ◽  
Normal Human ◽  
Human Polymorphonuclear Leukocytes

scholarly journals Molecular Typing of VapA-Positive Rhodococcus equi Isolates from Jeju Native Horses, Korea

2006 ◽  
Vol 68 (3) ◽  
pp. 249-253 ◽  
Author(s):  
Won-Geun SON ◽  
Du-Sik LEE ◽  
Noriko YAMATODA ◽  
Fumiko HATORI ◽  
Nanako SHIMIZU ◽  
...  
Keyword(s):  
Molecular Typing ◽  
Rhodococcus Equi

Medical management of pneumonia caused by Rhodococcus equi in a renal transplant recipient

2002 ◽  
Vol 39 (2) ◽  
pp. e7.1-e7.4 ◽  
Author(s):  
Francisco M. González-Roncero ◽  
Miguel A. Gentil ◽  
Gabriel Rodriguez-Algarra ◽  
Porfirio Pereira ◽  
Jose M. Cisneros ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Transplant Recipient ◽  
Renal Transplant Recipient ◽  
Medical Management ◽  
Rhodococcus Equi

scholarly journals Early development of cytotoxic T lymphocytes in neonatal foals following oral inoculation with Rhodococcus equi

2011 ◽  
Vol 141 (3-4) ◽  
pp. 312-316 ◽  
Author(s):  
Seth P. Harris ◽  
Melissa T. Hines ◽  
Robert H. Mealey ◽  
Debra C. Alperin ◽  
Stephen A. Hines
Keyword(s):  
T Lymphocytes ◽  
Early Development ◽  
Cytotoxic T Lymphocytes ◽  
Rhodococcus Equi ◽  
Oral Inoculation
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