Pharmacological evaluation of a novel corticotropin‐releasing factor 1 receptor antagonist T‐3047928 in stress‐induced animal models in a comparison with alosetron

2020 ◽  
Vol 32 (5) ◽  
Author(s):  
Yasuo Itomi ◽  
Takahiro Tanaka ◽  
Kozo Matsushita ◽  
Toru Kawamura ◽  
Takuto Kojima ◽  
...  
Keyword(s):  
Animal Models ◽  
Receptor Antagonist ◽  
Corticotropin Releasing Factor ◽  
Pharmacological Evaluation

scholarly journals Pharmacological evaluation of IQM-95,333, a highly selective CCKA receptor antagonist with anxiolytic-like activity in animal models

1997 ◽  
Vol 121 (4) ◽  
pp. 759-767 ◽  
Author(s):  
Santiago Ballaz ◽  
Ana Barber ◽  
Ana Fortuño ◽  
Joaquín Del Río ◽  
Mercedes Martín-Martínez ◽  
...  
Keyword(s):  
Animal Models ◽  
Receptor Antagonist ◽  
Pharmacological Evaluation

Effects of the selective 5-HT7 receptor antagonist SB-269970 in animal models of psychosis and cognition

2012 ◽  
Vol 228 (1) ◽  
pp. 211-218 ◽  
Author(s):  
Kerry A. Waters ◽  
Tania O. Stean ◽  
Beverley Hammond ◽  
David J. Virley ◽  
Neil Upton ◽  
...  
Keyword(s):  
Animal Models ◽  
Receptor Antagonist

scholarly journals ASP5736, a novel 5-HT5A receptor antagonist, ameliorates positive symptoms and cognitive impairment in animal models of schizophrenia

2014 ◽  
Vol 24 (10) ◽  
pp. 1698-1708 ◽  
Author(s):  
Mayako Yamazaki ◽  
Katsuya Harada ◽  
Noriyuki Yamamoto ◽  
Junko Yarimizu ◽  
Mayuko Okabe ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Animal Models ◽  
Receptor Antagonist ◽  
Positive Symptoms

Target engagement approaches for pharmacological evaluation in animal models

2019 ◽  
Vol 55 (63) ◽  
pp. 9241-9250 ◽  
Author(s):  
James E. Kath ◽  
Aleksandra Baranczak
Keyword(s):  
Animal Models ◽  
Small Molecules ◽  
Chemical Biology ◽  
Target Engagement ◽  
Pharmacological Evaluation

We highlight recent applications of chemical biology approaches to measure target engagement of small molecules in animal models to support the nomination of clinical candidates.

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