scholarly journals Landmark proportional subdistribution hazards models for dynamic prediction of cumulative incidence functions

2020 ◽  
Vol 69 (5) ◽  
pp. 1145-1162
Author(s):  
Qing Liu ◽  
Gong Tang ◽  
Joseph P. Costantino ◽  
Chung‐Chou H. Chang

2018 ◽  
Vol 60 (4) ◽  
pp. 734-747 ◽  
Author(s):  
Mia K. Grand ◽  
Theo J. M. de Witte ◽  
Hein Putter






2017 ◽  
Vol 35 (15_suppl) ◽  
pp. 10011-10011
Author(s):  
Kelly Kenzik ◽  
Courtney Balentine ◽  
Smita Bhatia ◽  
Grant Richard Williams

10011 Background: CRC is primarily a disease of the elderly. The high burden of pre-existing comorbidities alone or in concert with cancer treatment place the older patients with CRC at increased risk of new-onset morbidities, specifically, CVD and CHF. However, the magnitude of risk of new-onset morbidity, and its association with pre-existing comorbidities or treatment remain unknown. Methods: Using SEER-Medicare data, we evaluated individuals diagnosed with incident stage I-III CRC at age ≥66y between 1/1/2000 and 12/31/2011 who had survived ≥2y after diagnosis (n = 57,256; 77% with colon cancer). We compared these to an age, sex-, and race-frequency matched comparison group of non-cancer Medicare patients (n = 104,731). We evaluated new-onset CHF and CVD using competing risk cumulative incidence functions and multivariable Cox regression models. Results: The median age at diagnosis was 77y (66-106y); 45% males; and 85% non-Hispanic white. Median follow-up was 8y (2-14y) from diagnosis of CRC. Treatment included surgery for 99%, chemotherapy for 31%, and radiation for 12%. New-onset morbidity: The 10y cumulative incidence of new-onset CHF and CVD were 43.6% and 58.9%, respectively. After controlling for pre-cancer comorbidities, CRC survivors were at increased risk of new-onset CHF (HR 1.29) and CVD (HR 1.74) (all p < 0.001) compared to controls. Patients receiving radiation (HR 1.29) or 5-FU+oxaliplatin (HR 1.09) were at increased risk of CVD compared to those without those therapies (p < 0.001). Pre-existing diabetes (HR 1.16) and CHF (HR 1.21) independently increased the risk of CVD (p < 0.001). While 5FU+oxaliplatin did not increase the risk of CHF independently (HR 0.97), diabetic patients treated with 5-FU+oxaliplatin were at 1.71-fold increased risk of developing CHF (p < 0.001) when compared with those without pre-existing diabetes. Conclusions: Older CRC survivors are at increased of developing CHF and CVD. Monitoring survivors with a history of exposure to 5FU+oxaliplatin or radiation, and improving management of pre-existing comorbidities may reduce the burden of long-term morbidity for older CRC survivors.





2004 ◽  
Vol 10 (1) ◽  
pp. 5-28 ◽  
Author(s):  
Peter B. Gilbert ◽  
Ian W. Mckeague ◽  
Yanqing Sun


2010 ◽  
Vol 80 (9-10) ◽  
pp. 886-891 ◽  
Author(s):  
P.G. Sankaran ◽  
N. Unnikrishnan Nair ◽  
E.P. Sreedevi


2008 ◽  
Vol 27 (24) ◽  
pp. 4939-4949 ◽  
Author(s):  
Mei-Jie Zhang ◽  
Jason Fine


2004 ◽  
Vol 118 (1-2) ◽  
pp. 145-165 ◽  
Author(s):  
Hammou El Barmi ◽  
Subhash C. Kochar ◽  
Hari Mukerjee ◽  
Francisco J. Samaniego


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