scholarly journals More sophisticated than a drink cooler or an old sphygmomanometer but still not adequate for prehospital blood: A market review of commercially available equipment for prehospital blood transport and administration

Transfusion ◽  
2021 ◽  
Vol 61 (S1) ◽  
Author(s):  
Silver M. Martin ◽  
Andrew D. Fisher ◽  
Michael A. Meledeo ◽  
David Wampler ◽  
Susannah E. Nicholson ◽  
...  
1986 ◽  
Vol 250 (3) ◽  
pp. F476-F482
Author(s):  
N. Bank ◽  
H. S. Aynedjian ◽  
B. F. Mutz

Microperfusion studies were carried out in rats to examine the abnormality in proximal tubule HCO3- transport caused by maleic acid administration. Permeability of the proximal tubule to HCO-3 was measured by perfusing proximal tubules with a HCO3- -free low-buffer isotonic equilibrium solution containing acetazolamide after plasma [HCO3-] had been raised by intravenous NaHCO3 infusion. Insulin recovery in the collected perfusate was approximately 100% in control and maleic acid-treated rats. CO2 influx measured by microcalorimetry was not significantly different in control vs. maleic acid-treated rats. Thus maleic acid did not cause increased permeability of the proximal tubule to either inulin or HCO3-. In a second group of experiments, proximal tubule fluid and HCO3- efflux were measured in paired-reperfusion experiments before and after maleic acid administration. The perfusion fluid contained 25 mM HCO3- and 120 mM Cl-. HCO3- absorption was inhibited 25% (79 pmol/min), Na+ was inhibited 22% (164 pmol/min), and Cl- absorption (calculated as the anion gap) by 85 pmol/min. [HCO3-] in the collected perfusate rose significantly after maleic acid, presumably accompanied by a fall in [Cl-]. The observations indicate that proximal renal tubular acidosis (RTA) induced by maleic acid is characterized by impaired lumen-to-blood transport of sodium bicarbonate and chloride but not by increased backflux. Based on previously demonstrated effects of maleic acid on mitochondrial energy metabolism and cellular ATP levels, we postulate that the principal transport abnormality is impaired basolateral membrane active sodium transport, leading to a secondary reduction in brush border Na+-H+ exchange.(ABSTRACT TRUNCATED AT 250 WORDS)


Peptides ◽  
2002 ◽  
Vol 23 (3) ◽  
pp. 469-478 ◽  
Author(s):  
Ann Tronde ◽  
Eva Krondahl ◽  
Hans von Euler-Chelpin ◽  
Per Brunmark ◽  
Ursula Hultkvist Bengtsson ◽  
...  

Author(s):  
Svetlana Kodaneva ◽  

In the context of limited government budgets and the capacity of the banking sector, there is a need for new financial instruments to attract investment for the implementation of the Paris Agreement on Climate Change. One of such instruments is «green» bonds. The review analyzes the reasons for the growth of the «green» bond market in different countries and the prospects for its development.


2021 ◽  
Author(s):  
S.N. Yadav ◽  
N. Ahmed ◽  
A.J. Nath ◽  
P.K. Boro

The haematological analysis is one of the essential diagnostic and prognostic tools for the health practitioner. Routine hematology consists of erythrocyte, leucocyte and platelet parameters estimation. Erythrocyte parameters (RBC, RDW, haemoglobin, haematocrit, MCV, MCH, MCHC) estimation plays a crucial role in identifying anemia and several other acute and chronic conditions. Accurate and precise haematology results depend on correct blood collection procedures, suitable anticoagulants, proper storage and effective blood transport. The individual reference value variance can be due to age, sex, stress, diet, body condition, hydration status and reproductive status. Automatic haeamtology analyzer can yield quick and accurate results provided the sample is free from any artifacts. In conclusion, the accuracy of the result of automatic haematology analyzer in canine medicine is impeded by the lack of precise and rapid comparison procedure, instability and complexity of blood cells. Therefore the findings of the automatic haemotolyzer should always be corroborated with the clinical findings and another laboratory test.


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