scholarly journals Functionally heterogeneous synaptic vesicle pools support diverse synaptic signalling

2015 ◽  
Vol 594 (4) ◽  
pp. 825-835 ◽  
Author(s):  
Simon Chamberland ◽  
Katalin Tóth
Keyword(s):  
Synaptic Vesicle ◽  
Vesicle Pools ◽  
Synaptic Signalling

scholarly journals Regulation of synaptic vesicle recycling by calcineurin in different vesicle pools

2005 ◽  
Vol 51 (4) ◽  
pp. 435-443 ◽  
Author(s):  
Susumu Kumashiro ◽  
Yun-Fei Lu ◽  
Kazuhito Tomizawa ◽  
Masayuki Matsushita ◽  
Fan-Yan Wei ◽  
...  
Keyword(s):  
Synaptic Vesicle ◽  
Synaptic Vesicle Recycling ◽  
Vesicle Recycling ◽  
Vesicle Pools

scholarly journals FM 1-43 Labeling of Synaptic Vesicle Pools at the Drosophila Neuromuscular Junction

2008 ◽  
pp. 349-369 ◽  
Author(s):  
Patrik Verstreken ◽  
Tomoko Ohyama ◽  
Hugo J. Bellen
Keyword(s):  
Neuromuscular Junction ◽  
Synaptic Vesicle ◽  
Vesicle Pools

scholarly journals Synaptic vesicle pools are a major hidden resting metabolic burden of nerve terminals

2020 ◽  
Author(s):  
Camila Pulido ◽  
Timothy Aidan Ryan
Keyword(s):  
Cognitive Impairment ◽  
Steady State ◽  
Energy Consumption ◽  
Human Brain ◽  
Synaptic Vesicle ◽  
Atp Synthesis ◽  
Nerve Terminals ◽  
Metabolic Rates ◽  
On Demand ◽  
Vesicle Pools

The human brain is a uniquely vulnerable organ as interruption in fuel supply leads to acute cognitive impairment on rapid time scales. The reasons for this vulnerability are not well understood, but nerve terminals are likely loci of this vulnerability as they do not store sufficient ATP molecules and must synthesize them on-demand during activity or suffer acute degradation in performance. The requirements for on-demand ATP synthesis however depends in part on the magnitude of resting metabolic rates. We show here that, at rest, synaptic vesicle (SV) pools are a major source of presynaptic basal energy consumption. This basal metabolism arises from SV-resident V-ATPases compensating for a hidden resting H+ efflux from the SV lumen. We show that this steady-state H+ efflux is 1) mediated by vesicular neurotransmitter transporters, 2) independent of the SV cycle, 3) accounts for ~half of the resting synaptic energy consumption and 4) contributes to nerve terminal intolerance of fuel deprivation.

scholarly journals Synaptic vesicle pools are a major hidden resting metabolic burden of nerve terminals

2021 ◽  
Vol 7 (49) ◽  
Author(s):  
Camila Pulido ◽  
Timothy A. Ryan
Keyword(s):  
Synaptic Vesicle ◽  
Nerve Terminals ◽  
Metabolic Burden ◽  
Vesicle Pools

scholarly journals Synapsin Controls Both Reserve and Releasable Synaptic Vesicle Pools during Neuronal Activity and Short-Term Plasticity inAplysia

2001 ◽  
Vol 21 (12) ◽  
pp. 4195-4206 ◽  
Author(s):  
Yann Humeau ◽  
Frédéric Doussau ◽  
Francesco Vitiello ◽  
Paul Greengard ◽  
Fabio Benfenati ◽  
...  
Keyword(s):  
Synaptic Vesicle ◽  
Neuronal Activity ◽  
Short Term ◽  
Short Term Plasticity ◽  
Vesicle Pools
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