scholarly journals Protein kinase A-dependent enhanced NMDA receptor function in pain-related synaptic plasticity in rat amygdala neurones

2005 ◽  
Vol 564 (3) ◽  
pp. 907-921 ◽  
Author(s):  
Gary C. Bird ◽  
L. Leanne Lash ◽  
Jeong S. Han ◽  
Xiaoju Zou ◽  
William D. Willis ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Nmda Receptor ◽  
Protein Kinase ◽  
Protein Kinase A ◽  
Receptor Function ◽  
Nmda Receptor Function ◽  
Kinase A

scholarly journals Modulation of glucocorticoid receptor function by protein kinase A.

1992 ◽  
Vol 6 (9) ◽  
pp. 1451-1457 ◽  
Author(s):  
P N Rangarajan ◽  
K Umesono ◽  
R M Evans
Keyword(s):  
Protein Kinase ◽  
Glucocorticoid Receptor ◽  
Protein Kinase A ◽  
Receptor Function ◽  
Kinase A

scholarly journals Modulation of Human Mineralocorticoid Receptor Function by Protein Kinase A

1999 ◽  
Vol 13 (1) ◽  
pp. 57-65 ◽  
Author(s):  
Charbel Massaad ◽  
Nathalie Houard ◽  
Marc Lombès ◽  
Robert Barouki
Keyword(s):  
Protein Kinase ◽  
Protein Kinase A ◽  
Mineralocorticoid Receptor ◽  
Receptor Function ◽  
Kinase A

scholarly journals PrPC Controls via Protein Kinase A the Direction of Synaptic Plasticity in the Immature Hippocampus

2013 ◽  
Vol 33 (7) ◽  
pp. 2973-2983 ◽  
Author(s):  
M. D. Caiati ◽  
V. F. Safiulina ◽  
G. Fattorini ◽  
S. Sivakumaran ◽  
G. Legname ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Protein Kinase ◽  
Protein Kinase A ◽  
Kinase A

Opposing actions of protein kinase A and C mediate Hebbian synaptic plasticity

2001 ◽  
Vol 4 (9) ◽  
pp. 871-872 ◽  
Author(s):  
Min-Xu Li ◽  
Min Jia ◽  
Hao Jiang ◽  
Veronica Dunlap ◽  
Phillip G. Nelson
Keyword(s):  
Synaptic Plasticity ◽  
Protein Kinase ◽  
Protein Kinase A ◽  
Kinase A

Preconceptions and prerequisites: Understanding the function of synaptic plasticity will also depend on a better systems-level understanding of the multiple types of memory

1997 ◽  
Vol 20 (4) ◽  
pp. 624-625 ◽  
Author(s):  
Richard G. M. Morris
Keyword(s):  
Synaptic Plasticity ◽  
Cognitive Function ◽  
Nmda Receptor ◽  
Receptor Function ◽  
Relevant Evidence ◽  
Learning Hypothesis ◽  
Nmda Receptor Function

Although it is not their fault, Shors & Matzel's attempt to review the LTP and learning hypothesis suffers from there being no clear published statement of the idea. Their summary of relevant evidence is not without error, however, and it oversimplifies fundamental issues relating to NMDA receptor function. Their attentional hypothesis is intriguing but requires a better systems-level understanding of how attention contributes to cognitive function.

scholarly journals Enhancing NMDA Receptor Function: Recent Progress on Allosteric Modulators

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Lulu Yao ◽  
Qiang Zhou
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Synaptic Plasticity ◽  
Nmda Receptor ◽  
Recent Progress ◽  
Brain Diseases ◽  
Allosteric Modulators ◽  
Receptor Function ◽  
Nmda Receptor Function ◽  
Excitatory Neurotransmission

The N-methyl-D-aspartate receptors (NMDARs) are subtype glutamate receptors that play important roles in excitatory neurotransmission and synaptic plasticity. Their hypo- or hyperactivation are proposed to contribute to the genesis or progression of various brain diseases, including stroke, schizophrenia, depression, and Alzheimer’s disease. Past efforts in targeting NMDARs for therapeutic intervention have largely been on inhibitors of NMDARs. In light of the discovery of NMDAR hypofunction in psychiatric disorders and perhaps Alzheimer’s disease, efforts in boosting NMDAR activity/functions have surged in recent years. In this review, we will focus on enhancing NMDAR functions, especially on the recent progress in the generation of subunit-selective, allosteric positive modulators (PAMs) of NMDARs. We shall also discuss the usefulness of these newly developed NMDAR-PAMs.

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