scholarly journals Modulation of Human Mineralocorticoid Receptor Function by Protein Kinase A

1999 ◽  
Vol 13 (1) ◽  
pp. 57-65 ◽  
Author(s):  
Charbel Massaad ◽  
Nathalie Houard ◽  
Marc Lombès ◽  
Robert Barouki
Keyword(s):  
Protein Kinase ◽  
Protein Kinase A ◽  
Mineralocorticoid Receptor ◽  
Receptor Function ◽  
Kinase A

scholarly journals Modulation of glucocorticoid receptor function by protein kinase A.

1992 ◽  
Vol 6 (9) ◽  
pp. 1451-1457 ◽  
Author(s):  
P N Rangarajan ◽  
K Umesono ◽  
R M Evans
Keyword(s):  
Protein Kinase ◽  
Glucocorticoid Receptor ◽  
Protein Kinase A ◽  
Receptor Function ◽  
Kinase A

scholarly journals Protein kinase A-dependent enhanced NMDA receptor function in pain-related synaptic plasticity in rat amygdala neurones

2005 ◽  
Vol 564 (3) ◽  
pp. 907-921 ◽  
Author(s):  
Gary C. Bird ◽  
L. Leanne Lash ◽  
Jeong S. Han ◽  
Xiaoju Zou ◽  
William D. Willis ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Nmda Receptor ◽  
Protein Kinase ◽  
Protein Kinase A ◽  
Receptor Function ◽  
Nmda Receptor Function ◽  
Kinase A

scholarly journals Ethanol Activation of Protein Kinase A Regulates GABAAα1 Receptor Function and Trafficking in Cultured Cerebral Cortical Neurons

2013 ◽  
Vol 345 (2) ◽  
pp. 317-325 ◽  
Author(s):  
Stephen L. Carlson ◽  
Sandeep Kumar ◽  
David F. Werner ◽  
Christopher E. Comerford ◽  
A. Leslie Morrow
Keyword(s):  
Protein Kinase ◽  
Protein Kinase A ◽  
Cortical Neurons ◽  
Receptor Function ◽  
Cerebral Cortical Neurons ◽  
Kinase A

scholarly journals Biogenesis of the preprotein translocase of the outer mitochondrial membrane: protein kinase A phosphorylates the precursor of Tom40 and impairs its import

2012 ◽  
Vol 23 (9) ◽  
pp. 1618-1627 ◽  
Author(s):  
Sanjana Rao ◽  
Oliver Schmidt ◽  
Angelika B. Harbauer ◽  
Birgit Schönfisch ◽  
Bernard Guiard ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinase A ◽  
Mitochondrial Membrane ◽  
Inhibitory Effect ◽  
Outer Mitochondrial Membrane ◽  
Central Channel ◽  
Receptor Function ◽  
Tom Complex ◽  
Mitochondrial Membrane Protein ◽  
Kinase A

The preprotein translocase of the outer mitochondrial membrane (TOM) functions as the main entry gate for the import of nuclear-encoded proteins into mitochondria. The major subunits of the TOM complex are the three receptors Tom20, Tom22, and Tom70 and the central channel-forming protein Tom40. Cytosolic kinases have been shown to regulate the biogenesis and activity of the Tom receptors. Casein kinase 2 stimulates the biogenesis of Tom22 and Tom20, whereas protein kinase A (PKA) impairs the receptor function of Tom70. Here we report that PKA exerts an inhibitory effect on the biogenesis of the β-barrel protein Tom40. Tom40 is synthesized as precursor on cytosolic ribosomes and subsequently imported into mitochondria. We show that PKA phosphorylates the precursor of Tom40. The phosphorylated Tom40 precursor is impaired in import into mitochondria, whereas the nonphosphorylated precursor is efficiently imported. We conclude that PKA plays a dual role in the regulation of the TOM complex. Phosphorylation by PKA not only impairs the receptor activity of Tom70, but it also inhibits the biogenesis of the channel protein Tom40.

Sign in / Sign up

Export Citation Format

Share Document