scholarly journals A new approach to characterize postural deficits in chemotherapy-induced peripheral neuropathy and to analyze postural adaptions after an exercise intervention

2019 ◽  
Author(s):  
Sarah Kneis ◽  
Anja Wehrle ◽  
Daniela Dalin ◽  
Isabella Katharina Wiesmeier ◽  
Johann Lambeck ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Postural Control ◽  
Healthy Subjects ◽  
Exercise Intervention ◽  
Sensory Information ◽  
Control Model ◽  
Proprioceptive Information ◽  
New Approach ◽  
External Perturbations ◽  
Before And After

Abstract Background Postural instability presents a common and disabling consequence of chemotherapy-induced peripheral neuropathy (CIPN). However, knowledge about postural behavior of CIPN patients is sparse. With this pilot study, we used a new approach to i) characterize postural impairments as compared to healthy subjects, ii) allocate possible abnormalities to a set of parameters describing sensorimotor function, and iii) evaluate the effects of a balance-based exercise intervention. Methods We analyzed spontaneous and externally perturbed postural control in eight CIPN patients before and after a balance-based exercise intervention by using a modification of an established postural control model. These findings were compared to 15 matched healthy subjects. Results Spontaneous sway amplitude and velocity were larger in CIPN patients compared to healthy subjects. CIPN patients’ reactions to external perturbations were smaller compared to healthy subjects, indicating that patients favor vestibular over proprioceptive sensory information. The balance-based exercise intervention up-weighted proprioceptive information in patients. Conclusions CIPN patients’ major postural deficit may relate to underuse of proprioceptive information that results in a less accurate posture control as spontaneous sway results indicate. The balance-based exercise intervention is able to partially correct for this abnormality. Our study contributes to a better understanding of postural impairments in CIPN patients and suggests an effective treatment strategy.

A postural control model incorporating multisensory inputs for maintaining a musculoskeletal model in a stance posture

2016 ◽  
Vol 31 (1-2) ◽  
pp. 55-67 ◽  
Author(s):  
Ping Jiang ◽  
Ryosuke Chiba ◽  
Kaoru Takakusaki ◽  
Jun Ota
Keyword(s):  
Postural Control ◽  
Musculoskeletal Model ◽  
Control Model

scholarly journals Disentangling stability and flexibility degrees in Parkinson’s disease using a computational postural control model

2019 ◽  
Vol 16 (1) ◽  
Author(s):  
Zahra Rahmati ◽  
Alfred C. Schouten ◽  
Saeed Behzadipour ◽  
Ghorban Taghizadeh ◽  
Keikhosrow Firoozbakhsh
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Postural Control ◽  
Control Model

scholarly journals A new approach to characterize postural deficits in chemotherapy-induced peripheral neuropathy and to analyze postural adaptions after an exercise intervention

2019 ◽  
Author(s):  
Sarah Kneis ◽  
Anja Wehrle ◽  
Daniela Dalin ◽  
Isabella Katharina Wiesmeier ◽  
Johann Lambeck ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Postural Control ◽  
Healthy Subjects ◽  
Exercise Intervention ◽  
Sensory Information ◽  
Control Model ◽  
Proprioceptive Information ◽  
New Approach ◽  
External Perturbations ◽  
Before And After

Abstract Background Postural instability presents a common and disabling consequence of chemotherapy-induced peripheral neuropathy (CIPN). However, knowledge about postural behavior of CIPN patients is sparse. With this pilot study, we used a new approach to i) characterize postural impairments as compared to healthy subjects, ii) allocate possible abnormalities to a set of parameters describing sensorimotor function, and iii) evaluate the effects of a balance-based exercise intervention.Methods We analyzed spontaneous and externally perturbed postural control in eight CIPN patients before and after a balance-based exercise intervention by using a modification of an established postural control model. These findings were compared to 15 matched healthy subjects.Results Spontaneous sway amplitude and velocity were larger in CIPN patients compared to healthy subjects. CIPN patients’ reactions to external perturbations were smaller compared to healthy subjects, indicating that patients favor vestibular over proprioceptive sensory information. The balance-based exercise intervention up-weighted proprioceptive information in patients.Conclusion CIPN patients’ major postural deficit may relate to underuse of proprioceptive information that results in a less accurate posture control as spontaneous sway results indicate. The balance-based exercise intervention is able to partially correct for this abnormality. Our study contributes to a better understanding of postural impairments in CIPN patients and suggests an effective treatment strategy.

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