Model Complexity and Prestressing in Abdominal Aortic Aneurysm Simulation

Aortic Aneurysm ◽

Critical Diameter ◽

Model Complexity ◽

Prophylactic Surgery ◽

Western Society ◽

Rupture Risk ◽

Abdominal Aortic ◽

Precise Prediction ◽

The Individual

Rupture of abdominal aortic aneurysm (AAA) is the 13th leading cause of death in western society and is fatal in 70–90%. In consequence, precise prediction of AAA rupture risk is essential. With the current, well established CT-morphological parameters such as maximum aortic diameter, aneurysm shape and AAA expansion, only at best the relative, but not the individual rupture risk can be determined. Hence, AAA rupture may occur unexpectedly in small aneurysms below the critical diameter limits whereas many large aneurysms may remain stable throughout patient’s lifetime, without prophylactic surgery.

PATIENT-SPECIFIC CLINICAL ASSESSMENT OF ABDOMINAL AORTIC ANEURYSM RUPTURE RISK BASED ON ITS GEOMETRIC PARAMETERS

Biomedical Engineering ◽

10.2316/p.2010.723-051 ◽

2010 ◽

Cited By ~ 1

Author(s):

José Alberto Vilalta ◽

Mª. Ángeles Pérez ◽

Guillermo Vilalta ◽

Félix Nieto ◽

Carlos Vaquero

Keyword(s):

Aortic Aneurysm ◽

Clinical Assessment ◽

Aneurysm Rupture ◽

Geometric Parameters ◽

Patient Specific ◽

Rupture Risk ◽

Patient-Specific Clinical Assessment of Abdominal Aortic Aneurysm Rupture Risk based on its Geometric Parameters

Biomedical Engineering ◽

10.2316/p.2011.723-051 ◽

2011 ◽

Cited By ~ 1

Author(s):

Guillermo Vilalta ◽

Félix Nieto ◽

Carlos Vaquero ◽

José A. Vilalta ◽

Mária Ángeles Pérez

Keyword(s):

Aortic Aneurysm ◽

Clinical Assessment ◽

Aneurysm Rupture ◽

Geometric Parameters ◽

Patient Specific ◽

Rupture Risk ◽

NUMERICAL ANALYSIS OF THE WALL STRESS IN ABDOMINAL AORTIC ANEURYSM: INFLUENCE OF THE MATERIAL MODEL NEAR-INCOMPRESSIBILITY

Journal of Mechanics in Medicine and Biology ◽

10.1142/s0219519412004442 ◽

2012 ◽

Vol 12 (01) ◽

pp. 1250005 ◽

Cited By ~ 9

Author(s):

MAMADOU TOUNGARA ◽

GREGORY CHAGNON ◽

CHRISTIAN GEINDREAU

Keyword(s):

Finite Element ◽

Numerical Analysis ◽

Aortic Aneurysm ◽

Maximum Stress ◽

Mechanical Response ◽

Wall Stress ◽

Model Complexity ◽

Anisotropic Models ◽

Recently, hyperelastic mechanical models were proposed to well capture the aneurismal arterial wall anisotropic and nonlinear features experimentally observed. These models were formulated assuming the material incompressibility. However in numerical analysis, a nearly incompressible approach, i.e., a mixed formulation pressure-displacement, is usually adopted to perform finite element stress analysis of abdominal aortic aneurysm (AAA). Therefore, volume variations of the material are controlled through the volumetric energy which depends on the initial bulk modulus κ. In this paper, an analytical analysis of the influence of κ on the mechanical response of two invariant-based anisotropic models is first performed in the case of an equibiaxial tensile test. This analysis shows that for the strongly nonlinear anisotropic model, even in a restricted range of deformations, large values of κ are necessary to ensure the incompressibility condition, in order to estimate the wall stress with a reasonable precision. Finite element simulations on idealized AAA geometries are then performed. Results from these simulations show that the maximum stress in the AAA wall is underestimated in previous works, committed errors vary from 26% to 58% depending on the geometrical model complexity. In addition to affect the magnitude of the maximum stress in the aneurysm, we found that too small value of κ may also affect the location of this stress.

Grading Abdominal Aortic Aneurysm Rupture Risk

Journal of Vascular Surgery ◽

10.1016/j.jvs.2013.02.168 ◽

2013 ◽

Vol 57 (5) ◽

pp. 43S

Author(s):

Emiliano Chisci ◽

Neri Alamanni ◽

Francesca Iacoponi ◽

Stefano Michelagnoli ◽

Setacci Carlo

Keyword(s):

Aortic Aneurysm ◽

Aneurysm Rupture ◽

Rupture Risk ◽

Biomechanical Rupture Risk Assessment - A consistent and objective decision-making tool for Abdominal Aortic Aneurysm patients

Aorta ◽

10.12945/j.aorta.2016.15.030 ◽

2016 ◽

Vol 4 (2) ◽

Cited By ~ 12

Author(s):

T. Christian Gasser

Keyword(s):

Risk Assessment ◽

Decision Making ◽

Aortic Aneurysm ◽

Rupture Risk ◽

Abdominal Aortic ◽

Decision Making Tool

Robust and fast abdominal aortic aneurysm centerline detection for rupture risk prediction

10.1117/12.878128 ◽

2011 ◽

Author(s):

Hong Zhang ◽

Ender A. Finol

Keyword(s):

Aortic Aneurysm ◽

Risk Prediction ◽

Rupture Risk ◽

The Role of Geometric and Biomechanical Factors in Abdominal Aortic Aneurysm Rupture Risk Assessment

Annals of Biomedical Engineering ◽

10.1007/s10439-013-0786-6 ◽

2013 ◽

Vol 41 (7) ◽

pp. 1459-1477 ◽

Cited By ~ 52

Author(s):

Samarth S. Raut ◽

Santanu Chandra ◽

Judy Shum ◽

Ender A. Finol

Keyword(s):

Risk Assessment ◽

Aortic Aneurysm ◽

Aneurysm Rupture ◽

Rupture Risk ◽

Abdominal Aortic ◽

Biomechanical Factors

Background and Proposed Design for a Metformin Abdominal Aortic Aneurysm Suppression Trial

Vascular and Endovascular Review ◽

10.15420/ver.2020.03 ◽

2020 ◽

Vol 3 ◽

Author(s):

Ronald L Dalman ◽

Ying Lu ◽

Kenneth W Mahaffey ◽

Amanda J Chase ◽

Jordan R Stern ◽

...

Keyword(s):

Aortic Aneurysm ◽

Controlled Clinical Trial ◽

Rupture Risk ◽

Double Blind ◽

Abdominal Aortic ◽

Patients With Diabetes ◽

Risk Patients ◽

Toxic Potential ◽

Small Aneurysms

Abdominal aortic aneurysm (AAA) may lead to rupture and death if left untreated. While endovascular or surgical repair is generally recommended for AAA greater than 5–5.5 cm, the vast majority of aneurysms detected by screening modalities are smaller than this threshold. Once discovered, there would be a significant potential benefit in suppressing the growth of these small aneurysms in order to obviate the need for repair and mitigate rupture risk. Patients with diabetes, in particular those taking the oral hypoglycaemic medication metformin, have been shown to have lower incidence, growth rate, and rupture risk of AAA. Metformin therefore represents a widely available, non-toxic, potential inhibitor of AAA growth, but thus far no prospective clinical studies have evaluated this. Here, we present the background, rationale, and design for a randomised, double-blind, placebo-controlled clinical trial of metformin for growth suppression in patients with small AAA.