Bone Marrow Adipogenesis Is Affected by Insulin-Like Growth Factor-1 Complexes

2009 ◽  
Author(s):  
J. Christopher Fritton ◽  
Yuki Kawashima ◽  
Hui Sun ◽  
Yingjie Wu ◽  
Wilson Mejia ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Growth Factor ◽  
Bone Turnover ◽  
Cell Activity ◽  
Insulin Like Growth Factor ◽  
Fat Tissue ◽  
Mineralized Tissue ◽  
Mechanical Integrity ◽  
Bone Marrow Adipocytes

Fat tissue, which is composed of lipid-filled adipocytes that accumulate during aging, displaces mineralized tissue and reduces the mechanical integrity bone. Bone marrow adipocytes provide stroma for maintenance of mesencymal stem cells (MSC) and reside at sites of bone turnover (i.e., endosteal surfaces where osteoblasts form new bone), potentially influencing cell activity via a paracrine route.

scholarly journals Decorin inhibits the insulin-like growth factor I signaling in bone marrow mesenchymal stem cells of aged humans

Aging ◽  
2020 ◽  
Author(s):  
Tze-Hong Wong ◽  
Ting-Yu Chen ◽  
Kuo-Yun Tseng ◽  
Zih-Ying Chen ◽  
Chung-Hsing Chen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Growth Factor ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Marrow Mesenchymal Stem Cells ◽  
Growth Factor I

scholarly journals Overexpression of Insulin-Like Growth Factor 1 Enhanced the Osteogenic Capability of Aging Bone Marrow Mesenchymal Stem Cells

Theranostics ◽  
2017 ◽  
Vol 7 (6) ◽  
pp. 1598-1611 ◽  
Author(s):  
Ching-Yun Chen ◽  
Kuo-Yun Tseng ◽  
Yen-Liang Lai ◽  
Yo-Shen Chen ◽  
Feng-Huei Lin ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Growth Factor ◽  
Insulin Like Growth Factor ◽  
Marrow Mesenchymal Stem Cells
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