Lumbar Degenerative Disc Disease Increases Deformations at Cephalad Adjacent Levels In Vivo

2010 ◽  
Author(s):  
Shaobai Wang ◽  
Michal Kozanek ◽  
Kirkham B. Wood ◽  
Guoan Li
Keyword(s):  
Low Back ◽  
Working Population ◽  
Disc Disease ◽  
Lumbar Intervertebral Disc ◽  
Lumbar Degenerative Disc Disease ◽  
Degenerative Disc ◽  
Causative Factors ◽  
Common Causes ◽  
Ivd Degeneration

Low back pain, one of the most common causes of disability in working population is in the vast majority of cases attributed to degeneration of the lumbar intervertebral disc (IVD). It has been reported that in patients with degenerative disc diseases (DDD) at one level, the discs adjacent to the diseased level have a greater tendency to degenerate. Studies have also suggested altered biomechanics as causative factors [1, 2]. However, to date no data has been reported on the deformation of the disc in vivo in DDD patients. The purpose of this study was to evaluate the effect of lumbar IVD degeneration on the deformation of the discs at the adjacent levels during functional weightbearing postures.

scholarly journals Surgical outcomes of patients with degenerative lumbar disc disease post-IntraSPINE® device fixation: Three-year prospective study

2021 ◽  
Vol 8 (1) ◽  
pp. 01-10
Author(s):  
Doan Co-Minh
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Degenerative Disc Disease ◽  
Radicular Pain ◽  
Low Back ◽  
Disc Disease ◽  
Mixed Effect ◽  
Lumbar Degenerative Disc Disease ◽  
Degenerative Disc ◽  
Prospective Longitudinal

Background: Lumbar degenerative disc disease is one of the most common conditions associated with chronic low back pain. IntraSPINE® is a novel inter-laminar device that allows more physiological rocking-type movements in flexion and extension. Aim: To evaluate the results of patients with symptomatic Lumbar degenerative disc disease treated with an IntraSPINE® device and followed up over a 3-year period. Materials and Methods: A Prospective longitudinal research study involving patients with imaging-confirmed Lumbar degenerative disc disease in whom conservative treatment was unsuccessful. Outcome measures were changes over baseline score on the Oswestry Disability Index (ODI), and low back and radicular pain assessed at 6, 12, 24 and 36 months postoperatively. Overall success, a composite outcome that included key safety and clinical considerations, was assessed. Secondary outcomes included satisfaction with symptoms, employment status and post-surgery medical interventions. To compare differences in longitudinal clinical score patterns over 36 months, a mixed-effect model ANCOVA with repeated measurements was performed, with adjustment for low back and radicular pain score and ODI score at baseline. Results: 231 patients were recruited and 180 completed the study. A significant improvement in ODI score (p=0.0597), as well as in VAS (Visual Analogue Scale) scores for back (p= 0.0228) and leg pain (p<0.0001) was observed during the follow-up. For ODI score, the mean percentage decrease from inclusion to month 36 was 64.5%. These scores were respectively 66.2% for radicular pain and 46.4% for low back pain. In 73% of cases, surgery was considered successful. 89% of working patients returned to work and 68% of patients were very satisfied at month 12. Only four patients presented intraoperative complications.

scholarly journals How Does Lumbar Degenerative Disc Disease Affect the Disc Deformation at the Cephalic Levels In Vivo?

Spine ◽  
2011 ◽  
Vol 36 (9) ◽  
pp. E574-E581 ◽  
Author(s):  
Shaobai Wang ◽  
Qun Xia ◽  
Peter Passias ◽  
Weishi Li ◽  
Kirkham Wood ◽  
...  
Keyword(s):  
Degenerative Disc Disease ◽  
Disc Disease ◽  
Lumbar Degenerative Disc Disease ◽  
Degenerative Disc

Subclinical Infection and Disc Dysbiosis as a Cause of Degenerative Disc Disease and Low Back Pain

2020 ◽  
Author(s):  
S. Rajasekaran ◽  
S. Dilip Chand Raja ◽  
Chitraa Tangavel ◽  
M. Raveendran ◽  
K. S. Sri Vijay Anand ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Degenerative Disc Disease ◽  
Low Back ◽  
Subclinical Infection ◽  
Disc Disease ◽  
Degenerative Disc

scholarly journals Titanium-interlayer mediated hydroxyapatite coating on polyetheretherketone: a prospective study in patients with single-level cervical degenerative disc disease

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Ce Zhu ◽  
Miaomiao He ◽  
Lili Mao ◽  
Tao Li ◽  
Li Zhang ◽  
...  
Keyword(s):  
Degenerative Disc Disease ◽  
Fusion Rate ◽  
Peek Cage ◽  
Disc Disease ◽  
Degenerative Disc ◽  
Single Level ◽  
Cervical Degenerative Disc Disease ◽  
Post Operation

Abstract Background Currently, there are limited reports regarding investigation of the biological properties of polyetheretherketone (PEEK) coated with titanium (Ti) and hydroxyapatite (HA) in human. The objective of this study is to evaluate the in vivo response of the PEEK cages coated with Ti and HA versus uncoated PEEK cages after anterior cervical discectomy and fusion (ACDF) in patients with single-level cervical degenerative disc disease (CDDD). Methods Twenty-four patients with PEEK cages coated with Ti and HA (PEEK/Ti/HA group) were matched one-to-one with patients with uncoated PEEK cages (PEEK group) based on age, gender, and operative segment. All patients had been followed up for more than 2 years. Radiological assessments included intervertebral height (IH), C2-7 angle (C2-7a), segmental alignment (SA), and fusion rate. Clinical parameters included Visual Analogue Scale (VAS) and Japanese Orthopedic Association (JOA) scores. Results There was no statistical difference in SA, IH, and C2-7a between the two groups before and after surgery and all these parameters were restored postoperatively. The fusion rate of PEEK/Ti/HA group was significantly higher than PEEK group at 3-month post-operation (87.5% vs. 62.5%). At the last follow-up, the fusion rate of the both groups achieved 100%. The VAS and JOA scores were comparable between two groups and improved postoperatively. Conclusions In patients with single-level ACDF, PEEK cage coated with Ti and HA provided a higher fusion rate than uncoated PEEK cage at 3-month post-operation, while both two cages could achieve solid osseous fusion at the last follow up. Compared with the uncoated PEEK cage, PEEK/Ti/HA cage yielded similar favorable segmental and overall cervical lordosis, IH, and clinical outcomes after the surgery.

The Diagnostic Performance of Vertebral Displacement Measurements Derived From Ultrasonic Indentation in an In Vivo Model of Degenerative Disc Disease

Spine ◽  
2001 ◽  
Vol 26 (12) ◽  
pp. 1348-1355 ◽  
Author(s):  
Gregory N. Kawchuk ◽  
Allison M. Kaigle ◽  
Sten H. Holm ◽  
O. Rod Fauvel ◽  
Lars Ekström ◽  
...  
Keyword(s):  
Degenerative Disc Disease ◽  
Diagnostic Performance ◽  
In Vivo Model ◽  
Disc Disease ◽  
Degenerative Disc ◽  
Displacement Measurements

scholarly journals An in vivo model of degenerative disc disease

2003 ◽  
Vol 21 (1) ◽  
pp. 183-188 ◽  
Author(s):  
Jason P. Norcross ◽  
Gayle E. Lester ◽  
Paul Weinhold ◽  
Laurence E. Dahners
Keyword(s):  
Degenerative Disc Disease ◽  
In Vivo Model ◽  
Disc Disease ◽  
Degenerative Disc

Diagnosis of lumbar degenerative disc disease by using Lp-spaces related to generalized interval-valued m-polar neutrosophic choquet integral Operator

2021 ◽  
pp. 2150063
Author(s):  
Masooma Raza Hashmi ◽  
Muhammad Riaz
Keyword(s):  
Choquet Integral ◽  
Score Function ◽  
Aggregation Operator ◽  
Disc Disease ◽  
Neutrosophic Sets ◽  
Lumbar Degenerative Disc Disease ◽  
Degenerative Disc ◽  
Ranking Index ◽  
Interval Valued

Innovative and astonishing developments in the field of spine analysis can commence with this manuscript. The lumbar disks ([Formula: see text] to [Formula: see text]) are most commonly impaired by degeneration due to their long-standing degeneration and associated strain. We investigate the indications, purposes, risk factors, and therapies of lumbar degenerated disc disease (L-DDD). We assume that the degeneration of five discs creates many effects, making it difficult to differentiate between the different types of degenerated discs and their seriousness. Since the indeterminacy and falsity portions of science or clinical diagnosis are often ignored. Due to this complexity, the reliability of the patient’s progress report cannot be calculated, nor can the period of therapy be measured. The revolutionary concept of interval-valued m-polar neutrosophic Choquet integral aggregation operator (IVmPNCIAO) is proposed to eliminate these problems. We associate generalized interval-valued m-polar neutrosophic Choquet integral aggregation operator (GIVmPNCIAO) with the statistical formulation of [Formula: see text]-spaces and use it to identify the actual kind of degenerative disc in the lumbar spine. For the classification of interval-valued m-polar neutrosophic numbers (IVMPNNs), we set the ranking index and score function. These concepts are appropriate and necessary in order to better diagnose degeneration by associating it with mathematical modeling. We construct a pre-diagnosis map based on the fuzzy interval [0,1] to classify the types of degenerative discs. We develop an algorithm by using GIVmPNCIAO based on interval-valued m-polar neutrosophic sets (IVMPNNs) to identify the degenerative disc appropriately and to choose the most exquisite treatment for the corresponding degeneration of every patient. Furthermore, we discuss the sensitivity analysis with parameter [Formula: see text] in GIVmPNCIAO to investigate the patient’s improvement record.

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