To meet the approval test need of certain UAV, make up the shortfall of some test difficult to implement, according to the actual demand of the shooting range, the function needs of cruise UAV simulation system is presented based on HLA, the simulation environment is introduced, such as circulating system and supporting conditions. The implementing program of software & hardware and operation process of system is also designed, which has been applied to the development of certain UAV simulation system. Practical application indicated that the design is reasonable, easy to operate, and can meet the need of UAV weapon system simulation.Keywords: HLA; cruise UAV; weapon system; simulation; construction