scholarly journals Influence of reconstruction settings on the performance of adaptive thresholding algorithms for FDG-PET image segmentation in radiotherapy planning

2011 ◽  
Vol 12 (2) ◽  
pp. 115-132 ◽  
Author(s):  
Roberta Matheoud ◽  
Patrizia Della Monica ◽  
Gianfranco Loi ◽  
Luca Vigna ◽  
Marco Krengli ◽  
...  
Keyword(s):  
Image Segmentation ◽  
Fdg Pet ◽  
Adaptive Thresholding ◽  
Radiotherapy Planning

Multi-centre calibration of an adaptive thresholding method for PET-based delineation of tumour volumes in radiotherapy planning of lung cancer

2012 ◽  
Vol 51 (03) ◽  
pp. 101-110 ◽  
Author(s):  
U. Nestle ◽  
S. Kremp ◽  
D. Hellwig ◽  
A. Grgic ◽  
H. G. Buchholz ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Software Package ◽  
Adaptive Thresholding ◽  
Radiotherapy Planning ◽  
Imaging Protocols ◽  
Calibration Curves ◽  
Volume Delineation ◽  
Pet Ct ◽  
Ct Scanners ◽  
Calibration Parameters

SummaryPurpose: To evaluate the calibration of an adaptive thresholding algorithm (contrastoriented algorithm) for FDG PET-based delineation of tumour volumes in eleven centres with respect to scanner types and image data processing by phantom measurements. Methods: A cylindrical phantom with spheres of different diameters was filled with FDG realizing different signal-to-background ratios and scanned using 5 Siemens Biograph PET/CT scanners, 5 Philips Gemini PET/CT scanners, and one Siemens ECAT-ART PET scanner. All scans were analysed by the contrast-oriented algorithm implemented in two different software packages. For each site, the threshold SUVs of all spheres best matching the known sphere volumes were determined. Calibration parameters a and b were calculated for each combination of scanner and image-analysis software package. In addition, “scanner-typespecific” calibration curves were determined from all values obtained for each combination of scanner type and software package. Both kinds of calibration curves were used for volume delineation of the spheres. Results: Only minor differences in calibration parameters were observed for scanners of the same type (Δa ≤ 4%, Δb ≤ 14%) provided that identical imaging protocols were used whereas significant differences were found comparing calibration parameters of the ART scanner with those of scanners of different type (Δa ≤ 60%, Δb ≤ 54%). After calibration, for all scanners investigated the calculated SUV thresholds for auto-contouring did not differ significantly (all p > 0.58). The resulting sphere volumes deviated by less than –7% to +8% from the true values. Conclusion: After multi-centre calibration the use of the contrast-oriented algorithm for FDG PET-based delineation of tumour volumes in the different centres using different scanner types and specific imaging protocols is feasible.

1-[11C]-acetate PET imaging in head and neck cancer—a comparison with 18F-FDG-PET: implications for staging and radiotherapy planning

2006 ◽  
Vol 34 (5) ◽  
pp. 651-657 ◽  
Author(s):  
Aijun Sun ◽  
Jens Sörensen ◽  
Mikael Karlsson ◽  
Ingela Turesson ◽  
Bengt Langström ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Pet Imaging ◽  
Fdg Pet ◽  
Radiotherapy Planning ◽  
18F Fdg

Comparison of Gross Tumor Volume (GTV) determined by 18F-FDG PET/CT and MRI and paraortic limphadenectomy in radiotherapy planning in cervical cancer

2013 ◽  
Vol 18 ◽  
pp. S228
Author(s):  
S. Córdoba Largo ◽  
J. Corona Sánchez ◽  
M. Vázquez Masedo ◽  
P. Alcántara Carrió ◽  
A. Doval González ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Fdg Pet ◽  
Gross Tumor Volume ◽  
Tumor Volume ◽  
Radiotherapy Planning ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Ct And Mri

106PD DOES ELASTIC REGISTRATION ALTER FDG-PET BASED GTVS FOR RADIOTHERAPY PLANNING OF LUNG CANCER?

Lung Cancer ◽  
2009 ◽  
Vol 64 ◽  
pp. S46
Author(s):  
U. Nestle ◽  
A. Grgic ◽  
N. Moca ◽  
S. Kremp ◽  
A. Schaefer ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Fdg Pet ◽  
Radiotherapy Planning ◽  
Elastic Registration

scholarly journals 18F-FDG-PET/CT Imaging in Advanced Glottic Cancer: A Tool for Clinical Decision in Comparison with Conventional Imaging

2019 ◽  
Vol 2019 ◽  
pp. 1-12
Author(s):  
G. Paone ◽  
F. Martucci ◽  
V. Espeli ◽  
L. Ceriani ◽  
G. Treglia ◽  
...  
Keyword(s):  
Fdg Pet ◽  
False Negative ◽  
Ct Imaging ◽  
Radiotherapy Planning ◽  
Glottic Cancer ◽  
Conventional Imaging ◽  
Prognostic Information ◽  
Quantitative Pet ◽  
Pet Ct ◽  
Fdg Pet Ct

This study assessed the role of 18F-FDG PET-CT (PET/CT) to detect the cartilage and paraglottic infiltration in advanced glottic cancer comparing the results with those of conventional imaging (CI) (contrast-enhanced computed tomography and/or magnetic resonance). In addition, we assessed the prognostic value of quantitative parameters, measured on baseline PET/CT, in terms of event-free survival (EFS) and overall survival (OS). We retrospectively analyzed 27 patients with glottic squamous cell carcinoma stage III and IVA, treated in our institute between 2010 and 2016, comparing PET/CT, performed for staging and radiotherapy planning, and CI findings. Cohen’s K was used to compare concordance between PET/CT and CI. Imaging findings were correlated with endoscopic evaluation and histological reports (gold standard (GS)). All lesions shown by CI were also detected by PET/CT imaging, and in 5 cases, a better definition of local infiltration was achieved with PET/CT than CI (5 CT). Sensitivity, specificity, and accuracy of PET/CT and CT were 95%, 86%, and 93% and 70%, 86%, and 74% for, respectively. MRI showed sensitivity and specificity of 100%. One false-negative (FN) cases and 1 false-positive (FP) case were observed with PET/CT with no difference compared to MRI (10 cases). Six FN cases and 1 FP case were observed with CT. Cohen’s K was 0.60 (PET vs. CI) and 0.80 (PET vs. GS). Patients were followed-up for at least 24 months to calculate EFS and OS. 13 local recurrence and 7 deaths were recorded. Among quantitative PET parameters, baseline MTV was the most powerful predictor of outcome. Our data suggest a reliable sensitivity and accuracy of PET/CT in the evaluation of local extension, proving a useful method for initial local staging in addition to the well-established role in lymph-node and distant sites assessment. Furthermore, pretreatment MTV provides better prognostic information than other PET/CT parameters.

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