Inversion of ultrasonic scattering data for red blood cell suspensions under different flow conditions

1987 ◽  
Vol 82 (3) ◽  
pp. 794-799 ◽  
Author(s):  
R. J. Lucas ◽  
V. Twersky
1973 ◽  
Vol 19 ◽  
pp. 172-215

Carl Hamilton Browning was born in Glasgow on 21 May 1881. His grandfather, the Rev. Archibald Browning of Tillicoultry was, as Professor D. F. Cappell tells me, a vigorous Chartist and social reformer as well as a noted preacher, and both his father, Hugh Hamilton Browning, a graduate in Arts and Divinity at Edinburgh University, and his mother were gifted musicians. He himself was educated at Glasgow Academy, where he was Dux in 1896-97 and triple medallist in classics, English and mathematics. He took his medical training in Glasgow University, and, as he said himself, was even before he was qualified so attracted by Robert Muir and A. R. Ferguson that he asked Muir for a ‘subject’ to work on. Muir suggested that he look into the development of granular leucocytes in the human foetus. He did it, and by the time (1905) that the paper was printed he had in 1903 graduated M.B., Ch.B. with Honours; he then applied for the Coats Scholarship; no other candidate appeared, so he enjoyed the scholarship for some months, working with Muir on haemolytic sera. His time was not heavily loaded, and gave him opportunities for seeing the run of the Department and for a postgraduate course in medical bacteriology. Apart from this his only duty was to wash red blood cell suspensions in a hand-driven centrifuge until a small electrical one was built. He also tutored several students—an activity he strongly recommended as educational.


Soft Matter ◽  
2019 ◽  
Vol 15 (14) ◽  
pp. 2971-2980 ◽  
Author(s):  
Cécile Iss ◽  
Dorian Midou ◽  
Alexis Moreau ◽  
Delphine Held ◽  
Anne Charrier ◽  
...  

Microfluidic experiments and numerical simulations show that red blood cell suspensions self-organize into aligned structures under confined 2D flows.


Biorheology ◽  
1982 ◽  
Vol 19 (1-2) ◽  
pp. 253-267 ◽  
Author(s):  
Thao Chan ◽  
M.Y. Jaffrin ◽  
V. Seshadri ◽  
C. McKay

2013 ◽  
Vol 110 (10) ◽  
Author(s):  
Xavier Grandchamp ◽  
Gwennou Coupier ◽  
Aparna Srivastav ◽  
Christophe Minetti ◽  
Thomas Podgorski

2011 ◽  
Vol 676 ◽  
pp. 348-375 ◽  
Author(s):  
L. CROWL ◽  
A. L. FOGELSON

The concentration of platelets near the blood vessel wall is important because platelets survey the condition of the vessel wall and respond to injuries to it. Under arterial flow conditions, platelets are non-uniformly distributed across the vessel lumen and have a high concentration within a few microns of the vessel wall. This is believed to be a consequence of the complex motion of red blood cells which constitute a large fraction of the blood's volume. We use a novel lattice Boltzmann-immersed boundary method to simulate, in two dimensions, the motion of dense red blood cell suspensions and their effect on platelet-sized particles. We track the development of a red blood cell-free layer near the wall and the later development of the platelet near-wall excess. We find that the latter develops more quickly at high wall shear rates and that the magnitude of the excess and its proximity to the wall are dependent on haematocrit. Treating the simulation data as if it were generated by a drift–diffusion process, we find that the effective lateral platelet diffusivity depends strongly on lateral position; it has a magnitude of order of 10−6 cm2 s−1 over much of the lumen but drops to almost zero close to the wall. This large effective diffusivity over the core of the lumen combined with reduced space for platelets in this region because of the inward migration of red blood cells largely but not completely accounts for the observed platelet-concentration profiles. We present evidence for a highly localized red blood cell-induced platelet drift at the edge of the red cell-free layer and suggest a physical mechanism that may generate it.


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