Distortion product otoacoustic emission (2 f1−f2) amplitude as a function of f2/f1 frequency ratio and primary tone level separation in human adults and neonates

1996 ◽  
Vol 100 (6) ◽  
pp. 3726-3740 ◽  
Author(s):  
Carolina Abdala
Keyword(s):  
Frequency Ratio ◽  
Otoacoustic Emission ◽  
Distortion Product Otoacoustic Emission ◽  
Distortion Product ◽  
Human Adults ◽  
Tone Level

The effect of stimulus-frequency ratio on distortion product otoacoustic emission components

2005 ◽  
Vol 117 (6) ◽  
pp. 3766-3776 ◽  
Author(s):  
Sumitrajit Dhar ◽  
Glenis R. Long ◽  
Carrick L. Talmadge ◽  
Arnold Tubis
Keyword(s):  
Frequency Ratio ◽  
Stimulus Frequency ◽  
Otoacoustic Emission ◽  
Distortion Product Otoacoustic Emission ◽  
Distortion Product

Distortion product otoacoustic emission suppression tuning curves in human adults and neonates

1996 ◽  
Vol 98 (1-2) ◽  
pp. 38-53 ◽  
Author(s):  
Carolina Abdala ◽  
Yvonne S. Sininger ◽  
Michael Ekelid ◽  
Fan-Gang Zeng
Keyword(s):  
Otoacoustic Emission ◽  
Distortion Product Otoacoustic Emission ◽  
Tuning Curves ◽  
Distortion Product ◽  
Human Adults

Human Frequency-Following Response Correlates of the Distortion Product at 2F1-F2

2004 ◽  
Vol 15 (03) ◽  
pp. 184-197 ◽  
Author(s):  
Pritesh K. Pandya ◽  
Ananthanarayan Krishnan
Keyword(s):  
Otoacoustic Emission ◽  
Output Growth ◽  
Distinct Region ◽  
Distortion Product Otoacoustic Emission ◽  
Low Frequencies ◽  
Frequency Following Response ◽  
Distortion Product ◽  
Growth Functions ◽  
Tone Level ◽  
Amplitude Growth

We characterized the 2F1-F2 distortion product reflected in the human frequency-following response (FFR). In the first experiment, we evaluated the input-output growth functions of the distortion product at 2F1-F2 (FFR-DP) for three primary pairs. In the second experiment, we tested the effect of primary tone level variation on the FFR-DP. The results for all three stimulus pairs showed that while the amplitude of FFR-DP increased with stimulus intensity, the slope of the amplitude growth decreased with increasing frequency. Consistent with distortion product otoacoustic emission (DPOAE) data, our observations suggest that there is a distinct region where the separation of the primary tone levels produces maximal distortion. The robust FFR-DP measure could complement the less reliable DPOAE at low frequencies and when middle ear pathology precludes its measurement.

Pengaruh sisplatin dosis tinggi terhadap penurunan fungsi sel rambut luar koklea

2013 ◽  
Vol 40 (2) ◽  
Author(s):  
Asti Kristianti ◽  
Teti Madiadipoera ◽  
Bogi Soeseno
Keyword(s):  
Hair Cells ◽  
Malignant Neoplasm ◽  
Otoacoustic Emission ◽  
Outer Hair Cells ◽  
High Dose ◽  
Distortion Product Otoacoustic Emission ◽  
Inclusion Criteria ◽  
Cochlear Hair Cells ◽  
Distortion Product ◽  
Bilateral Sensorineural Hearing Loss

Background: Chemotherapy is worldwide used nowadays, and its toxicity still remain a problemespecially toxicity to the ear (ototoxicity). Cisplatin (cis-diamminedichloroplatinum) is one of themost commonly used chemotherapy and highly potent in treating epithelial malignancies. Ototoxicitycaused by cisplatin is irreversible, progressive, bilateral, sensorineural hearing loss especially on highfrequency (4-8 KHz) accompanied by tinnitus. Purpose: To observe the cochlear outer hair cells damagein malignancies patients treated with cisplatin. Methods: This study is an observational analytic studywith prospective design to determine the influence of high dose cisplatin on cochlear outer hair cellsfunction. The research was carried out at the ENT-HNS Department, Hasan Sadikin General HospitalBandung, from November 2007 until June 2008. Audiometry, tympanometry, and distortion productotoacoustic emission (DPOAE) examinations were conducted before chemotherapy and DPOAE, andtimpanometry was again measured three days after first and second cycles of cisplatin administration. McNemar test was performed to calculate the effects of high-dose cisplatin to the cochlear outer haircells function. To compare pre and post-cisplatin on alteration of cochlear hair cells function, Wilcoxontest was used. Results: In this study 60 ears from 30 subjects that meet the inclusion criteria, consistedof 25 man (83.3%) and 5 women (16.7%). The prevalence of damaged cochlear outer hair cells were63% at first cycle and 70% at second cycle of cisplatin administration. The decline of cochlear outerhair cells function was significant (p<0.001). Conclusion: High-dose cisplatin decreases cochlear outerhair cells function in patients with malignant neoplasm. Abstrak : Latar belakang: Kemoterapi sekarang rutin digunakan secara klinis di seluruh dunia. Sejalan denganhal tersebut toksisitas kemoterapi, khususnya terhadap telinga saat ini menjadi perhatian. Sisplatin(cis-diamminedichloroplatinum) adalah salah satu obat kemoterapi yang paling banyak digunakandan paling manjur untuk terapi keganasan epitelial. Efek ototoksik sisplatin yaitu terjadi gangguandengar sensorineural yang irreversible, progresif, bilateral pada frekuensi tinggi (4-8 kHz), dan disertaidengan tinitus. Tujuan: Untuk menilai penurunan fungsi sel rambut luar koklea pada penderita tumorganas sesudah pemberian sisplatin dosis tinggi dengan menggunakan DPOAE. Metode: Studi analitikobservasional dengan rancangan prospektif di Bagian IK. THT-KL RS. Hasan Sadikin Bandung mulaibulan November 2007 sampai dengan Juni 2008. Pada penelitian ini dilakukan pemeriksaan audiometrinada murni, timpanometri, dan distortion product otoacoustic emission (DPOAE) prakemoterapi, kemudianDPOAE dan timpanometri diulang tiga hari sesudah siklus pertama dan kedua kemoterapi sisplatin. Datayang diperoleh diuji dengan uji McNemar dan uji Wilcoxon. Hasil: Dari penelitian didapat 60 telingadari 30 subjek penelitian yang memenuhi kriteria inklusi yang terdiri dari 25 laki-laki (83,3%) dan 5perempuan (16,7%). Insidens penurunan fungsi sel rambut luar koklea sebesar 63% (38 kasus) sesudahsiklus pertama dan 70% (42 kasus) sesudah siklus kedua. Hubungan penurunan fungsi sel rambut luarkoklea memberikan nilai yang sangat bermakna sejak pemberian siklus pertama (p<0,001). Kesimpulan:Pemberian sisplatin dosis tinggi pada penderita tumor ganas menyebabkan penurunan fungsi sel rambutluar koklea.Kata kunci: kemoterapi, sisplatin dosis tinggi, sel rambut luar koklea.

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