Pengaruh sisplatin dosis tinggi terhadap penurunan fungsi sel rambut luar koklea

2013 ◽  
Vol 40 (2) ◽  
Author(s):  
Asti Kristianti ◽  
Teti Madiadipoera ◽  
Bogi Soeseno
Keyword(s):  
Hair Cells ◽  
Malignant Neoplasm ◽  
Otoacoustic Emission ◽  
Outer Hair Cells ◽  
High Dose ◽  
Distortion Product Otoacoustic Emission ◽  
Inclusion Criteria ◽  
Cochlear Hair Cells ◽  
Distortion Product ◽  
Bilateral Sensorineural Hearing Loss

Background: Chemotherapy is worldwide used nowadays, and its toxicity still remain a problemespecially toxicity to the ear (ototoxicity). Cisplatin (cis-diamminedichloroplatinum) is one of themost commonly used chemotherapy and highly potent in treating epithelial malignancies. Ototoxicitycaused by cisplatin is irreversible, progressive, bilateral, sensorineural hearing loss especially on highfrequency (4-8 KHz) accompanied by tinnitus. Purpose: To observe the cochlear outer hair cells damagein malignancies patients treated with cisplatin. Methods: This study is an observational analytic studywith prospective design to determine the influence of high dose cisplatin on cochlear outer hair cellsfunction. The research was carried out at the ENT-HNS Department, Hasan Sadikin General HospitalBandung, from November 2007 until June 2008. Audiometry, tympanometry, and distortion productotoacoustic emission (DPOAE) examinations were conducted before chemotherapy and DPOAE, andtimpanometry was again measured three days after first and second cycles of cisplatin administration. McNemar test was performed to calculate the effects of high-dose cisplatin to the cochlear outer haircells function. To compare pre and post-cisplatin on alteration of cochlear hair cells function, Wilcoxontest was used. Results: In this study 60 ears from 30 subjects that meet the inclusion criteria, consistedof 25 man (83.3%) and 5 women (16.7%). The prevalence of damaged cochlear outer hair cells were63% at first cycle and 70% at second cycle of cisplatin administration. The decline of cochlear outerhair cells function was significant (p<0.001). Conclusion: High-dose cisplatin decreases cochlear outerhair cells function in patients with malignant neoplasm. Abstrak : Latar belakang: Kemoterapi sekarang rutin digunakan secara klinis di seluruh dunia. Sejalan denganhal tersebut toksisitas kemoterapi, khususnya terhadap telinga saat ini menjadi perhatian. Sisplatin(cis-diamminedichloroplatinum) adalah salah satu obat kemoterapi yang paling banyak digunakandan paling manjur untuk terapi keganasan epitelial. Efek ototoksik sisplatin yaitu terjadi gangguandengar sensorineural yang irreversible, progresif, bilateral pada frekuensi tinggi (4-8 kHz), dan disertaidengan tinitus. Tujuan: Untuk menilai penurunan fungsi sel rambut luar koklea pada penderita tumorganas sesudah pemberian sisplatin dosis tinggi dengan menggunakan DPOAE. Metode: Studi analitikobservasional dengan rancangan prospektif di Bagian IK. THT-KL RS. Hasan Sadikin Bandung mulaibulan November 2007 sampai dengan Juni 2008. Pada penelitian ini dilakukan pemeriksaan audiometrinada murni, timpanometri, dan distortion product otoacoustic emission (DPOAE) prakemoterapi, kemudianDPOAE dan timpanometri diulang tiga hari sesudah siklus pertama dan kedua kemoterapi sisplatin. Datayang diperoleh diuji dengan uji McNemar dan uji Wilcoxon. Hasil: Dari penelitian didapat 60 telingadari 30 subjek penelitian yang memenuhi kriteria inklusi yang terdiri dari 25 laki-laki (83,3%) dan 5perempuan (16,7%). Insidens penurunan fungsi sel rambut luar koklea sebesar 63% (38 kasus) sesudahsiklus pertama dan 70% (42 kasus) sesudah siklus kedua. Hubungan penurunan fungsi sel rambut luarkoklea memberikan nilai yang sangat bermakna sejak pemberian siklus pertama (p<0,001). Kesimpulan:Pemberian sisplatin dosis tinggi pada penderita tumor ganas menyebabkan penurunan fungsi sel rambutluar koklea.Kata kunci: kemoterapi, sisplatin dosis tinggi, sel rambut luar koklea.

scholarly journals Effect of Using N95 and Surgical Masks on Otoacoustic Emission in Cochlear Outer Hair Cells

2021 ◽  
pp. 014556132110346
Author(s):  
Sedat Alagoz ◽  
Kemal Koray Bal ◽  
Talih Ozdas ◽  
Vedat Delibas ◽  
Gokhan Kuran ◽  
...  
Keyword(s):  
Hair Cells ◽  
Otoacoustic Emission ◽  
Outer Hair Cells ◽  
Distortion Product Otoacoustic Emission ◽  
Distortion Product ◽  
Surgical Masks ◽  
Before And After ◽  
Group 2 ◽  
The Right ◽  
Group 1

Introduction: Distortion product otoacoustic emission (DPOAE) was measured to investigate the effect of mask use and type on oxygen saturation on cochlear function in health care professionals during the COVID-19 pandemic. Material and Methods: Group 1 participants wore surgical masks; Group 2 participants wore N95 masks. Distortion product otoacoustic emission and oxygen saturation were measured in both groups before and after mask use. Results: Comparison of signal-to-noise ratio (SNR) values before and after surgical mask use in DPOAE measurements of group 1 revealed statistically significant difference in the right and left ears. Comparison of the SNR values in DPOAE measurements of group 2 before and after 8 hours of N95 mask use revealed statistically significant differences in the right ear at 988, 2963, 4444, and 8000 Hz and in the left ear at 8000 Hz. Conclusion: We found that prolonged mask use may affect the outer hair cells in the cochlea, causing deterioration in DPOAE values.

scholarly journals Preeclampsia as a Risk Factor for Damage of the Cochlear Outer Hair Cells Function

2016 ◽  
Vol 2016 ◽  
pp. 1-4
Author(s):  
Oppy Surya Atmaja ◽  
Kartono Sudarman ◽  
Agus Surono
Keyword(s):  
Hair Cells ◽  
Outer Hair Cell ◽  
Cell Function ◽  
Blood Pressure Measurement ◽  
Otoacoustic Emission ◽  
Organ Damage ◽  
Outer Hair Cells ◽  
Distortion Product Otoacoustic Emission ◽  
Multisystem Disorder ◽  
Distortion Product

Preeclampsia is one of the most common complications of pregnancy in the world. In Indonesia, the incidence of preeclampsia lies within 3–10% of all pregnancies every year. Preeclampsia is a multisystem disorder that causes endothelial dysfunction and vasospasm that may lead to ischemia and organ damage especially to the end organs. Cochlea serves as an end organ and is therefore vulnerable to damage under ischemic conditions. This research aimed to understand the role of preeclampsia on the destruction of cochlear outer hair cells function. Subjects were pregnant women who were hospitalized in the Obstetrics and Gynecology Ward of Sardjito Hospital. Diagnosis of preeclampsia was obtained by defining level of high blood pressure measurement and quantitative 24 hours of proteinuria. Meanwhile, cochlear outer hair cell function was measured by the distortion product otoacoustic emission (DPOAE). The DPOAE results showed that REFER presented in 6 (10%) patients with preeclampsia and none in those without preeclampsia groups. This result demonstrated preeclampsia as one of the risk factors for impaired function of cochlear outer hair cells.

scholarly journals Deletion of Oncomodulin Gives Rise to Early Progressive Cochlear Dysfunction in C57 and CBA Mice

2021 ◽  
Vol 13 ◽  
Author(s):  
Leslie K. Climer ◽  
Aubrey J. Hornak ◽  
Kaitlin Murtha ◽  
Yang Yang ◽  
Andrew M. Cox ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Cell Function ◽  
Otoacoustic Emission ◽  
Cell Types ◽  
Auditory Brainstem ◽  
Outer Hair Cells ◽  
Distortion Product Otoacoustic Emission ◽  
Distortion Product ◽  
Age Related ◽  
Brainstem Response

Ca2+ signaling is a major contributor to sensory hair cell function in the cochlea. Oncomodulin (OCM) is a Ca2+ binding protein (CaBP) preferentially expressed in outer hair cells (OHCs) of the cochlea and few other specialized cell types. Here, we expand on our previous reports and show that OCM delays hearing loss in mice of two different genetic backgrounds: CBA/CaJ and C57Bl/6J. In both backgrounds, genetic disruption of Ocm leads to early progressive hearing loss as measured by auditory brainstem response (ABR) and distortion product otoacoustic emission (DPOAE). In both strains, loss of Ocm reduced hearing across lifetime (hearing span) by more than 50% relative to wild type (WT). Even though the two WT strains have very different hearing spans, OCM plays a considerable and similar role within their genetic environment to regulate hearing function. The accelerated age-related hearing loss (ARHL) of the Ocm KO illustrates the importance of Ca2+ signaling in maintaining hearing health. Manipulation of OCM and Ca2+ signaling may reveal important clues to the systems of function/dysfunction that lead to ARHL.

scholarly journals Correlation between schroeder-phase effect and distortion product otoacoustic emission findings

2016 ◽  
Vol 15 (1) ◽  
Author(s):  
Nur Baizura Salahuddin ◽  
Sarah Rahmat
Keyword(s):  
Pure Tone Audiometry ◽  
Otoacoustic Emission ◽  
Outer Hair Cells ◽  
Output Function ◽  
Distortion Product Otoacoustic Emission ◽  
Input Output ◽  
Phase Effect ◽  
Cochlear Function ◽  
Distortion Product ◽  
Effect Mechanism

Introduction: Schroeder-phase masking has been proven to be more sensitive than pure tone audiometry in detecting changes in cochlear function. Schroeder harmonic complexes with different phases have been observed to excite basilar membranes differently and give different masking abilities (‘phase effect’) when used as maskers. Previous theory suggested that phase effect was contributed by cochlear non-linearity of outer hair cells (OHC); however the theory was derived from behavioral observation alone. Therefore, this study aims to further investigate the cochlear non-linearity involvement in phase effect mechanism by measuring the Schroeder phase effect together with another electrophysiological test that measures the cochlear non-linearity function, i.e. Distortion Product Otoacoustic Emission (DPOAE). Methods: Twelve normal hearing and four sensorineural hearing loss subjects were recruited. Schroeder phase masking test was conducted and phase effect (using 75 dB A masker) at 1kHz and 2 kHz was measured. DPOAE was recorded at multiple intensities (45-75 dB SPL) for 1 kHz and 2 kHz, and slope of DPOAE input output function was measured. Correlation analysis was performed to find correlation between phase effect and slope of DPOAE input output function. Results: Result showed no significant correlation (p > 0.05) between phase effect and slope of DPOAE input output function. Conclusions: This findings suggest that Schroeder-phase effect may not be/ may not only be contributed by OHC’s cochlear non-linearity. This finding opens the possibility of other auditory functions’ involvement in phase effect mechanism, and contribute to better understanding towards auditory perceptions.

scholarly journals Oncomodulin Delays Age-Related Hearing Loss in C57 and CBA Mice

2021 ◽  
Author(s):  
Leslie K Climer ◽  
Aubrey J Hornak ◽  
Kaitlin Murtha ◽  
Yang Yang ◽  
Andrew M Cox ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Cell Function ◽  
Otoacoustic Emission ◽  
Auditory Brainstem ◽  
Outer Hair Cells ◽  
Distortion Product Otoacoustic Emission ◽  
Progressive Hearing Loss ◽  
Distortion Product ◽  
Age Related ◽  
Brainstem Response

Ca2+ signaling is a major contributor to sensory hair cell function in the cochlea. Oncomodulin (OCM) is a Ca2+ binding protein preferentially expressed in outer hair cells of the cochlea and few other specialized cell types. Here, we expand on our previous reports and show that OCM prevents early progressive hearing loss in mice of two different genetic backgrounds: CBA/CaJ and C57Bl/6J. In both backgrounds, genetic disruption of Ocm leads to early progressive hearing loss as measured by auditory brainstem response (ABR) and distortion product otoacoustic emission (DPOAE). In both strains, loss of Ocm reduced hearing across lifetime (hearing span) by more than 50% relative to wild type (WT). Even though the two WT strains have very different hearing spans, OCM plays a considerable and similar role within their genetic environment to regulate hearing function. The accelerated ARHL of the Ocm KO illustrates the importance of Ca2+ signaling in maintaining hearing health.

scholarly journals Effect of Radiofrequency Waves of Mobile Phones on Distortion Product Otoacoustic Emissions

2021 ◽  
Author(s):  
Swetapadma Nayak ◽  
Rajeshwary Aroor ◽  
Usha Shastri ◽  
M. K. Goutham ◽  
Devika Sinha
Keyword(s):  
Mobile Phone ◽  
Mobile Phones ◽  
Otoacoustic Emissions ◽  
Prolonged Exposure ◽  
Otoacoustic Emission ◽  
Distortion Product Otoacoustic Emission ◽  
Cochlear Hair Cells ◽  
Post Exposure ◽  
Distortion Product ◽  
Significant Difference

Abstract Objective The prolonged exposure to electromagnetic fields of mobile phones can damage the cochlear hair cells, which can be detected by otoacoustic emission (OAE). To know the effect of mobile phones on hearing, the young volunteers were subjected to prolonged mobile phone usage and changes in OAE were recorded. Materials and Methods Twenty-eight volunteers with normal hearing were made to talk one full hour continuously on the mobile phone. Distortion product otoacoustic emission (DPOAE) was measured prior to the usage of mobile phones and immediately after the use (post-exposure 1) and 24 hours after the use (post-exposure 2). The values were compared. Results Out of the 28 volunteers, 20 were females and 8 were males. Twenty-one volunteers preferred the right ear while using mobile phones, 7 preferred the left ear. There was no statistically significant difference between the baseline DPOAE values and values of post-exposure 1 and 2 when only the preferred ear was taken into consideration. When the preferred ear was compared with nonpreferred ear, a statistically significant difference was found only in the low frequencies between the pre-exposure and post-exposure 1 values. Conclusion This study shows there was no significant correlation between OAE and prolonged mobile phone exposure when the preferred ear was not considered.

scholarly journals Estimation of outer hair cells function in chronic bilateral tinnitus patients with normal hearing using distortion product otoacoustic emissions

2021 ◽  
Author(s):  
Aras Karimiani ◽  
Nematollah Rouhbakhsh ◽  
Farzaneh Zamiri Abdollahi ◽  
Shohreh Jalaie
Keyword(s):  
Hair Cells ◽  
Otoacoustic Emissions ◽  
Normal Hearing ◽  
Outer Hair Cells ◽  
Distortion Product Otoacoustic Emissions ◽  
Control Group ◽  
Distortion Product Otoacoustic Emission ◽  
Frequency Range ◽  
Cochlear Function ◽  
Distortion Product

Background and Aim: It is not clear if the measurement of distortion product otoacoustic emissions (DPOAE) at frequencies above 8 kHz adds any value in determining the differences in the cochlear function between patients with and without tinnitus. This study aimed to compare DPOAE in the frequency range of 0.5−10 kHz in patients with normal hearing with and without tinnitus. Methods: This comparative cross-sectional study was conducted on 20 individuals with tinnitus and normal hearing as a study group (SG) and a control group (CG) of 20 normal-hearing individuals without tinnitus. The DPOAE was measured with F1/F2 = 1.22 and intensities of F1 = 65 dB SPL and F2 =55 dB SPL in the frequency range of 0.5−10 kHz, moreover in the frequency of tinnitus in SG and corresponding frequency in CG. Results: DPOAE level at 10 kHz did not differ significantly between SG and CG (p = 0.491). However, the mean of overall DPOAE level, DPOAE level at the frequency of tinnitus, and F2 values of 2.5, 5, and 6.298 kHz were significantly lower in SG than CG (p < 0.05). Conclusion: Measurement of DPOAE at 10 kHz did not seem to add any value in determining the differences in the cochlear function between patients with and without tinnitus. However, decreased DPOAE levels at 2.5, 5, and 6.298 kHz which were observed among patients who have tinnitus and normal hearing, indicates some outer hair cells damage that was not detectable by conventional audiometry. Keywords: Tinnitus; normal hearing; outer hair cell; distortion product otoacoustic emission

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