IN VITRO AND IN VIVO EVALUATION OF THE METABOLISM AND BIOAVAILABILITY OF ESTER PRODRUGS OF MGS0039 (3-(3,4-DICHLOROBENZYLOXY)-2-AMINO-6-FLUOROBICYCLO[3.1.0]HEXANE-2,6-DICARBOXYLIC ACID), A POTENT METABOTROPIC GLUTAMATE RECEPTOR ANTAGONIST

In Vivo Evaluation ◽

Metabotropic Glutamate ◽

Ester Prodrugs ◽

Evaluation of the activity of a novel metabotropic glutamate receptor antagonist (±)-2-amino-2-(3-cis and trans-carboxycyclobutyl-3-(9-thioxanthyl)propionic acid) in the in vitro neonatal spinal cord and in an in vivo pain model

Neuroscience ◽

10.1016/s0306-4522(99)00496-0 ◽

1999 ◽

Vol 95 (3) ◽

pp. 787-793 ◽

Cited By ~ 21

Author(s):

Y. Chen ◽

G. Bacon ◽

E. Sher ◽

B.P. Clark ◽

M.J. Kallman ◽

...

Keyword(s):

Spinal Cord ◽

Glutamate Receptor ◽

Pain Model ◽

Metabotropic Glutamate ◽

Cis And Trans ◽

Synthesis, radiolabeling, in vitro and in vivo evaluation of [18F]-FPECMO as a positron emission tomography radioligand for imaging the metabotropic glutamate receptor subtype 5

Nuclear Medicine and Biology ◽

10.1016/j.nucmedbio.2009.03.005 ◽

2009 ◽

Vol 36 (6) ◽

pp. 613-622 ◽

Cited By ~ 14

Author(s):

Christophe Lucatelli ◽

Michael Honer ◽

Jean-Frédéric Salazar ◽

Tobias L. Ross ◽

P. August Schubiger ◽

...

Keyword(s):

Positron Emission Tomography ◽

Glutamate Receptor ◽

Emission Tomography ◽

Receptor Subtype ◽

In Vivo Evaluation ◽

Metabotropic Glutamate ◽

Positron Emission

Synthesis and metabotropic glutamate receptor antagonist activity of N1-substituted analogs of 2R,4R-4-aminopyrrolidine-2,4-dicarboxylic acid

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(98)00352-7 ◽

1998 ◽

Vol 8 (15) ◽

pp. 1985-1990 ◽

Cited By ~ 12

Author(s):

Matthew J Valli ◽

Darryle D Schoepp ◽

Rebecca A Wright ◽

Bryan G Johnson ◽

Ann E Kingston ◽

...

Keyword(s):

Dicarboxylic Acid ◽

Receptor Antagonist ◽

Glutamate Receptor ◽

Antagonist Activity ◽

Metabotropic Glutamate ◽

In vitro and in vivo evaluation of [18F]-FDEGPECO as a PET tracer for imaging the metabotropic glutamate receptor subtype 5 (mGluR5)

NeuroImage ◽

10.1016/j.neuroimage.2011.03.024 ◽

2011 ◽

Vol 56 (3) ◽

pp. 984-991 ◽

Cited By ~ 11

Author(s):

Cindy A. Wanger-Baumann ◽

Linjing Mu ◽

Michael Honer ◽

Sara Belli ◽

Malte F. Alf ◽

...

Keyword(s):

Glutamate Receptor ◽

Receptor Subtype ◽

In Vivo Evaluation ◽

Metabotropic Glutamate ◽

Pet Tracer

Radiolabeling and in vitro and in vivo evaluation of [18F]-FE-DABP688 as a PET radioligand for the metabotropic glutamate receptor subtype 5

Nuclear Medicine and Biology ◽

10.1016/j.nucmedbio.2007.07.017 ◽

2007 ◽

Vol 34 (8) ◽

pp. 973-980 ◽

Cited By ~ 21

Author(s):

Michael Honer ◽

Anja Stoffel ◽

Lea J. Kessler ◽

P. August Schubiger ◽

Simon M. Ametamey

Keyword(s):

Glutamate Receptor ◽

Receptor Subtype ◽

In Vivo Evaluation ◽

Metabotropic Glutamate

The metabotropic glutamate receptor antagonist ( + )-α-methyl-4-carboxyphenylglycine protects hippocampal CA1 neurons of the rat from in vitro hypoxia/hypoglycemia

Neuropharmacology ◽

10.1016/0028-3908(94)90178-3 ◽

1994 ◽

Vol 33 (5) ◽

pp. 715-717 ◽

Cited By ~ 35

Author(s):

T. Opitz ◽

P. Richter ◽

K.G. Reymann

Keyword(s):

Receptor Antagonist ◽

Glutamate Receptor ◽

Ca1 Neurons ◽

Metabotropic Glutamate ◽

Hippocampal Ca1 Neurons ◽

Hippocampal Ca1 ◽

ChemInform Abstract: Synthesis and Metabotropic Glutamate Receptor Antagonist Activity of N1-Substituted Analogues of 2R,4R-4-Aminopyrrolidine-2,4-dicarboxylic Acid.

ChemInform ◽

10.1002/chin.199847227 ◽

2010 ◽

Vol 29 (47) ◽

pp. no-no

Author(s):

M. J. VALLI ◽

D. D. SCHOEPP ◽

R. A. WRIGHT ◽

B. G. JOHNSON ◽

A. E. KINGSTON ◽

...

Keyword(s):

Dicarboxylic Acid ◽

Receptor Antagonist ◽

Glutamate Receptor ◽

Antagonist Activity ◽

Metabotropic Glutamate ◽

Clinical studies with the metabotropic glutamate receptor antagonist AFQ056voglurant in adults and adolescents with fragile X syndrome

Neuropsychiatrie de l Enfance et de l Adolescence ◽

10.1016/j.neurenf.2012.04.288 ◽

2012 ◽

Vol 60 (5) ◽

pp. S178

Author(s):

T. Jaecklin ◽

B. Koumaras ◽

A. Angelov ◽

C. Collober ◽

F.N. Hossain ◽

...

Keyword(s):

Receptor Antagonist ◽

Fragile X Syndrome ◽

Glutamate Receptor ◽

Clinical Studies ◽

Fragile X ◽

Metabotropic Glutamate ◽

Effects of the metabotropic glutamate receptor antagonist MCPG on spatial and context-specific learning

Neuropharmacology ◽

10.1016/s0028-3908(96)00101-3 ◽

1996 ◽

Vol 35 (11) ◽

pp. 1557-1565 ◽

Cited By ~ 28

Author(s):

Fabio Bordi ◽

Clara Marcon ◽

Christian Chiamulera ◽

Angelo Reggiani

Keyword(s):

Receptor Antagonist ◽

Glutamate Receptor ◽

Metabotropic Glutamate ◽

Context Specific ◽

Specific Learning ◽

The molecular switch hypothesis fails to explain the inconsistent effects of the metabotropic glutamate receptor antagonist MCPG on long-term potentiation

Brain Research ◽

10.1016/0006-8993(95)00757-h ◽

1995 ◽

Vol 695 (1) ◽

pp. 45-52 ◽

Cited By ~ 33

Author(s):

Mark J. Thomas ◽

Thomas J. O'Dell

Keyword(s):

Receptor Antagonist ◽

Glutamate Receptor ◽

Long Term Potentiation ◽

Molecular Switch ◽

Metabotropic Glutamate ◽

Term Potentiation ◽