Evaluation of the activity of a novel metabotropic glutamate receptor antagonist (±)-2-amino-2-(3-cis and trans-carboxycyclobutyl-3-(9-thioxanthyl)propionic acid) in the in vitro neonatal spinal cord and in an in vivo pain model

Pain Model ◽

Metabotropic Glutamate ◽

Cis And Trans ◽

IN VITRO AND IN VIVO EVALUATION OF THE METABOLISM AND BIOAVAILABILITY OF ESTER PRODRUGS OF MGS0039 (3-(3,4-DICHLOROBENZYLOXY)-2-AMINO-6-FLUOROBICYCLO[3.1.0]HEXANE-2,6-DICARBOXYLIC ACID), A POTENT METABOTROPIC GLUTAMATE RECEPTOR ANTAGONIST

Drug Metabolism and Disposition ◽

10.1124/dmd.105.006213 ◽

2005 ◽

Vol 34 (3) ◽

pp. 369-374 ◽

Cited By ~ 11

Author(s):

Masato Nakamura ◽

Yasunori Kawakita ◽

Akito Yasuhara ◽

Yoshiki Fukasawa ◽

Koji Yoshida ◽

...

Keyword(s):

Dicarboxylic Acid ◽

Glutamate Receptor ◽

In Vivo Evaluation ◽

Metabotropic Glutamate ◽

Ester Prodrugs ◽

The metabotropic glutamate receptor antagonist ( + )-α-methyl-4-carboxyphenylglycine protects hippocampal CA1 neurons of the rat from in vitro hypoxia/hypoglycemia

Neuropharmacology ◽

10.1016/0028-3908(94)90178-3 ◽

1994 ◽

Vol 33 (5) ◽

pp. 715-717 ◽

Cited By ~ 35

Author(s):

T. Opitz ◽

P. Richter ◽

K.G. Reymann

Keyword(s):

Receptor Antagonist ◽

Glutamate Receptor ◽

Ca1 Neurons ◽

Metabotropic Glutamate ◽

Hippocampal Ca1 Neurons ◽

Hippocampal Ca1 ◽

Clinical studies with the metabotropic glutamate receptor antagonist AFQ056voglurant in adults and adolescents with fragile X syndrome

Neuropsychiatrie de l Enfance et de l Adolescence ◽

10.1016/j.neurenf.2012.04.288 ◽

2012 ◽

Vol 60 (5) ◽

pp. S178

Author(s):

T. Jaecklin ◽

B. Koumaras ◽

A. Angelov ◽

C. Collober ◽

F.N. Hossain ◽

...

Keyword(s):

Receptor Antagonist ◽

Fragile X Syndrome ◽

Glutamate Receptor ◽

Clinical Studies ◽

Fragile X ◽

Metabotropic Glutamate ◽

Effects of the metabotropic glutamate receptor antagonist MCPG on spatial and context-specific learning

Neuropharmacology ◽

10.1016/s0028-3908(96)00101-3 ◽

1996 ◽

Vol 35 (11) ◽

pp. 1557-1565 ◽

Cited By ~ 28

Author(s):

Fabio Bordi ◽

Clara Marcon ◽

Christian Chiamulera ◽

Angelo Reggiani

Keyword(s):

Receptor Antagonist ◽

Glutamate Receptor ◽

Metabotropic Glutamate ◽

Context Specific ◽

Specific Learning ◽

The molecular switch hypothesis fails to explain the inconsistent effects of the metabotropic glutamate receptor antagonist MCPG on long-term potentiation

Brain Research ◽

10.1016/0006-8993(95)00757-h ◽

1995 ◽

Vol 695 (1) ◽

pp. 45-52 ◽

Cited By ~ 33

Author(s):

Mark J. Thomas ◽

Thomas J. O'Dell

Keyword(s):

Receptor Antagonist ◽

Glutamate Receptor ◽

Long Term Potentiation ◽

Molecular Switch ◽

Metabotropic Glutamate ◽

Term Potentiation ◽

Absolute Configuration of (+)-α-Methyl-4-carboxyphenylglycine (MCPG), a Metabotropic Glutamate Receptor Antagonist

Acta Crystallographica Section C Crystal Structure Communications ◽

10.1107/s0108270197003223 ◽

1997 ◽

Vol 53 (7) ◽

pp. 909-911 ◽

Cited By ~ 3

Author(s):

C. Wilson ◽

J. A. K. Howard ◽

D. E. Jane ◽

D. C. Sunter ◽

J. C. Watkins

Keyword(s):

Receptor Antagonist ◽

Glutamate Receptor ◽

Absolute Configuration ◽

Metabotropic Glutamate ◽

AMPA receptor stimulation mediates the antidepressant-like effect of a group II metabotropic glutamate receptor antagonist

Brain Research ◽

10.1016/j.brainres.2005.02.032 ◽

2005 ◽

Vol 1042 (1) ◽

pp. 92-98 ◽

Cited By ~ 100

Author(s):

Jun-ichi Karasawa ◽

Toshiharu Shimazaki ◽

Naoya Kawashima ◽

Shigeyuki Chaki

Keyword(s):

Receptor Antagonist ◽

Glutamate Receptor ◽

Ampa Receptor ◽

Receptor Stimulation ◽

Metabotropic Glutamate ◽

Group Ii ◽

Relationship between In Vivo Receptor Occupancy and Efficacy of Metabotropic Glutamate Receptor Subtype 5 Allosteric Modulators with Different In Vitro Binding Profiles

Neuropsychopharmacology ◽

10.1038/npp.2014.245 ◽

2014 ◽

Vol 40 (3) ◽

pp. 755-765 ◽

Cited By ~ 22

Author(s):

Jerri M Rook ◽

Mohammed N Tantawy ◽

Mohammad S Ansari ◽

Andrew S Felts ◽

Shaun R Stauffer ◽

...

Keyword(s):

Glutamate Receptor ◽

Receptor Occupancy ◽

Receptor Subtype ◽

Allosteric Modulators ◽

Metabotropic Glutamate ◽

In Vitro Binding ◽

Vitro Binding

Antinociceptive effect of a group II metabotropic glutamate receptor antagonist in the thalamus of monoarthritic rats

Neuroscience Letters ◽

10.1016/s0304-3940(00)01613-x ◽

2000 ◽

Vol 296 (1) ◽

pp. 25-28 ◽

Cited By ~ 17

Author(s):

Fani Lourenço Neto ◽

José Manuel Castro-Lopes

Keyword(s):

Receptor Antagonist ◽

Glutamate Receptor ◽

Antinociceptive Effect ◽

Metabotropic Glutamate ◽

Group Ii ◽

Synthesis, radiolabeling, in vitro and in vivo evaluation of [18F]-FPECMO as a positron emission tomography radioligand for imaging the metabotropic glutamate receptor subtype 5

Nuclear Medicine and Biology ◽

10.1016/j.nucmedbio.2009.03.005 ◽

2009 ◽

Vol 36 (6) ◽

pp. 613-622 ◽

Cited By ~ 14

Author(s):

Christophe Lucatelli ◽

Michael Honer ◽

Jean-Frédéric Salazar ◽

Tobias L. Ross ◽

P. August Schubiger ◽

...

Keyword(s):

Positron Emission Tomography ◽

Glutamate Receptor ◽

Emission Tomography ◽

Receptor Subtype ◽

In Vivo Evaluation ◽

Metabotropic Glutamate ◽

Positron Emission