Complex Cytochrome P450 kinetics due to multisubstrate binding and sequential metabolism. Part 1. Theoretical considerations.

2021 ◽  
pp. DMD-AR-2021-000553
Author(s):  
Zeyuan Wang ◽  
Erickson M. Paragas ◽  
Swati Nagar ◽  
Ken Korzekwa
Keyword(s):  
Cytochrome P450 ◽  
Sequential Metabolism ◽  
Theoretical Considerations

Cytochrome P450 6M2 from the malaria vector Anopheles gambiae metabolizes pyrethroids: Sequential metabolism of deltamethrin revealed

2011 ◽  
Vol 41 (7) ◽  
pp. 492-502 ◽  
Author(s):  
Bradley J. Stevenson ◽  
Jaclyn Bibby ◽  
Patricia Pignatelli ◽  
Sant Muangnoicharoen ◽  
Paul M. O’Neill ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Anopheles Gambiae ◽  
Malaria Vector ◽  
Sequential Metabolism

SEQUENTIAL METABOLISM OF 2,3,7-TRICHLORODIBENZO-P-DIOXIN (2,3,7-triCDD) BY CYTOCHROME P450 AND UDP-GLUCURONOSYLTRANSFERASE IN HUMAN LIVER MICROSOMES

2004 ◽  
Vol 32 (8) ◽  
pp. 870-875 ◽  
Author(s):  
Noriyuki Kasai ◽  
Toshiyuki Sakaki ◽  
Raku Shinkyo ◽  
Shin-ichi Ikushiro ◽  
Takashi Iyanagi ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Sequential Metabolism ◽  
Udp Glucuronosyltransferase

Sequential Metabolism of Sesamin by Cytochrome P450 and UDP-Glucuronosyltransferase in Human Liver

2011 ◽  
Vol 39 (9) ◽  
pp. 1538-1545 ◽  
Author(s):  
Kaori Yasuda ◽  
Shinichi Ikushiro ◽  
Masaki Kamakura ◽  
Eiji Munetsuna ◽  
Miho Ohta ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Sequential Metabolism ◽  
Udp Glucuronosyltransferase

Molecular evolution of a cytochrome P450 for the synthesis of potential antidepressant (2R,6R)-hydroxynorketamine

2021 ◽  
Author(s):  
Ansgar Bokel ◽  
Michael C. Hutter ◽  
Vlada B. Urlacher
Keyword(s):  
Cytochrome P450 ◽  
Molecular Evolution ◽  
Cytochrome P450 Monooxygenase ◽  
P450 Monooxygenase ◽  
Effective Synthesis

Engineered cytochrome P450 monooxygenase CYP154E1 enables the effective synthesis of the potential antidepressant (2R,6R)-hydroxynorketamine via N-demethylation and regio- and stereoselective hydroxylation of (R)-ketamine.

Comparison of mechanism-based inhibition of human cytochrome P450 2C19 by ticlopidine, clopidogrel, and prasugrel

Xenobiotica ◽  
2009 ◽  
Vol 00 (00) ◽  
pp. 090901052457079-8
Author(s):  
Y. Nishiya ◽  
K. Hagihara ◽  
A. Kurihara ◽  
N. Okudaira ◽  
N.A. Farid ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Human Cytochrome ◽  
Cytochrome P450 2C19

Deactivation of anti-cancer drug letrozole to a carbinol metabolite by polymorphic cytochrome P450 2A6 in human liver microsomes

Xenobiotica ◽  
2009 ◽  
Vol 00 (00) ◽  
pp. 090901052053001-8
Author(s):  
K. Murai ◽  
H. Yamazaki ◽  
K. Nakagawa ◽  
R. Kawai ◽  
T. Kamataki
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Cancer Drug ◽  
Anti Cancer ◽  
Cytochrome P450 2A6
Sign in / Sign up

Export Citation Format

Share Document