Evaluation of the Permeation Characteristics of a Model Opioid Peptide, H-Tyr-d-Ala-Gly-Phe-d-Leu-OH (DADLE), and Its Cyclic Prodrugs across the Blood-Brain Barrier Using an In Situ Perfused Rat Brain Model

2002 ◽  
Vol 303 (2) ◽  
pp. 849-857 ◽  
Author(s):  
Weiqing Chen ◽  
Jerry Z. Yang ◽  
Rikke Andersen ◽  
Lisbeth H. Nielsen ◽  
Ronald T. Borchardt
Keyword(s):  
Rat Brain ◽  
Blood Brain Barrier ◽  
Opioid Peptide ◽  
Brain Barrier ◽  
Blood Brain ◽  
Cyclic Prodrugs

A comparison of the effects of p-glycoprotein inhibitors on the blood–brain barrier permeation of cyclic prodrugs of an opioid peptide (DADLE)

2009 ◽  
Vol 98 (6) ◽  
pp. 2227-2236 ◽  
Author(s):  
Hui Ouyang ◽  
Thomas E. Andersen ◽  
Weiqing Chen ◽  
Rebecca Nofsinger ◽  
Bente Steffansen ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Opioid Peptide ◽  
Brain Barrier ◽  
P Glycoprotein ◽  
Blood Brain ◽  
Cyclic Prodrugs ◽  
Glycoprotein Inhibitors

Investigation of Transport Mechanism of Pentazocine across the Blood‐Brain Barrier Using the In Situ Rat Brain Perfusion Technique

2002 ◽  
Vol 91 (11) ◽  
pp. 2346-2353 ◽  
Author(s):  
Toyofumi Suzuki ◽  
Masakazu Oshimi ◽  
Kazuo Tomono ◽  
Manabu Hanano ◽  
Jun Watanabe
Keyword(s):  
Rat Brain ◽  
Blood Brain Barrier ◽  
Transport Mechanism ◽  
Brain Perfusion ◽  
Brain Barrier ◽  
Perfusion Technique ◽  
Blood Brain
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