A Novel Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Has in Vivo Activity and Antipsychotic-Like Effects in Rat Behavioral Models

Receptor Subtype ◽

Allosteric Modulator ◽

Behavioral Models ◽

Discovery of 3-aminopicolinamides as metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator warheads engendering CNS exposure and in vivo efficacy

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2016.04.041 ◽

2016 ◽

Vol 26 (12) ◽

pp. 2915-2919 ◽

Cited By ~ 1

Author(s):

Rocco D. Gogliotti ◽

Darren W. Engers ◽

Pedro M. Garcia-Barrantes ◽

Joseph D. Panarese ◽

Patrick R. Gentry ◽

...

Keyword(s):

Glutamate Receptor ◽

Receptor Subtype ◽

Allosteric Modulator ◽

In Vivo Efficacy ◽

Metabotropic Glutamate ◽

Cns Exposure

A Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 2 Blocks a Hallucinogenic Drug Model of Psychosis

Molecular Pharmacology ◽

10.1124/mol.107.035170 ◽

2007 ◽

Vol 72 (2) ◽

pp. 477-484 ◽

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Author(s):

Michael A. Benneyworth ◽

Zixiu Xiang ◽

Randy L. Smith ◽

Efrain E. Garcia ◽

P. Jeffrey Conn ◽

...

Keyword(s):

Glutamate Receptor ◽

Receptor Subtype ◽

Allosteric Modulator ◽

Metabotropic Glutamate ◽

Hallucinogenic Drug

Biphenyl-indanone A, a Positive Allosteric Modulator of the Metabotropic Glutamate Receptor Subtype 2, Has Antipsychotic- and Anxiolytic-Like Effects in Mice

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.106.102046 ◽

2006 ◽

Vol 318 (1) ◽

pp. 173-185 ◽

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Author(s):

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Carrie K. Jones ◽

Kamondanai Hemstapat ◽

Yi Nong ◽

Nicholas G. Echemendia ◽

...

Keyword(s):

Glutamate Receptor ◽

Receptor Subtype ◽

Allosteric Modulator ◽

Design and Synthesis of an Orally Active Metabotropic Glutamate Receptor Subtype-2 (mGluR2) Positive Allosteric Modulator (PAM) That Decreases Cocaine Self-Administration in Rats

Journal of Medicinal Chemistry ◽

10.1021/jm1012165 ◽

2011 ◽

Vol 54 (1) ◽

pp. 342-353 ◽

Cited By ~ 34

Author(s):

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Shyama Sidique ◽

Douglas J. Sheffler ◽

Hilary Highfield Nickols ◽

Ananda Herath ◽

...

Keyword(s):

Glutamate Receptor ◽

Receptor Subtype ◽

Allosteric Modulator ◽

Self Administration ◽

Metabotropic Glutamate ◽

Design And Synthesis ◽

Orally Active

Biotransformation of a Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Contributes to Seizure-Like Adverse Events in Rats Involving a Receptor Agonism-Dependent Mechanism

Drug Metabolism and Disposition ◽

10.1124/dmd.113.052084 ◽

2013 ◽

Vol 41 (9) ◽

pp. 1703-1714 ◽

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Author(s):

Thomas M. Bridges ◽

Jerri M. Rook ◽

Meredith J. Noetzel ◽

Ryan D. Morrison ◽

Ya Zhou ◽

...

Keyword(s):

Adverse Events ◽

Glutamate Receptor ◽

Receptor Subtype ◽

Allosteric Modulator ◽

Metabotropic Glutamate ◽

Dependent Mechanism

Discovery of Novel Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Reveals Chemical and Functional Diversity and In Vivo Activity in Rat Behavioral Models of Anxiolytic and Antipsychotic Activity

Molecular Pharmacology ◽

10.1124/mol.110.067207 ◽

2010 ◽

Vol 78 (6) ◽

pp. 1105-1123 ◽

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Author(s):

Alice L. Rodriguez ◽

Mark D. Grier ◽

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Elizabeth J. Herman ◽

Alexander S. Kane ◽

...

Keyword(s):

Functional Diversity ◽

Glutamate Receptor ◽

Receptor Subtype ◽

Allosteric Modulators ◽

Behavioral Models ◽

Metabotropic Glutamate ◽

Antipsychotic Activity

In vitro binding of a radio-labeled positive allosteric modulator for metabotropic glutamate receptor subtype 5

Synapse ◽

10.1002/syn.21625 ◽

2012 ◽

Vol 67 (3) ◽

pp. 135-144 ◽

Cited By ~ 2

Author(s):

John R. Zysk ◽

Nathan Spear ◽

William Fieles ◽

Mark M. Stein ◽

Linda S. Sygowski ◽

...

Keyword(s):

Glutamate Receptor ◽

Receptor Subtype ◽

Allosteric Modulator ◽

Metabotropic Glutamate ◽

In Vitro Binding ◽

Vitro Binding

Potent and selective pharmacodynamic synergy between the metabotropic glutamate receptor subtype 2-positive allosteric modulator JNJ-46356479 and levetiracetam in the mouse 6-Hz (44-mA) model

Epilepsia ◽

10.1111/epi.14005 ◽

2018 ◽

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Author(s):

Cameron S. Metcalf ◽

Brian D. Klein ◽

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Marc Ceusters ◽

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Keyword(s):

Glutamate Receptor ◽

Receptor Subtype ◽

Allosteric Modulator ◽

In vitro and in vivo characterization of MPEP, an allosteric modulator of the metabotropic glutamate receptor subtype 5: Review article

Amino Acids ◽

10.1007/s00726-001-0130-6 ◽

2002 ◽

Vol 23 (1-3) ◽

pp. 207-211 ◽

Cited By ~ 37

Author(s):

R. Kuhn ◽

A. Pagano ◽

N. Stoehr ◽

I. Vranesic ◽

P. J. Flor ◽

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Keyword(s):

Glutamate Receptor ◽

Review Article ◽

Receptor Subtype ◽

Allosteric Modulator ◽

Metabotropic Glutamate ◽

In Vivo Characterization

The Novel Metabotropic Glutamate Receptor 2 Positive Allosteric Modulator, AZD8529, Decreases Nicotine Self-Administration and Relapse in Squirrel Monkeys

Biological Psychiatry ◽

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2015 ◽

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Author(s):

Zuzana Justinova ◽

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Keyword(s):

Glutamate Receptor ◽

Squirrel Monkeys ◽

Allosteric Modulator ◽

The Novel ◽

Self Administration ◽