Pharmacological Characterization of MK-0974 [N-[(3R,6S)-6-(2,3-Difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide], a Potent and Orally Active Calcitonin Gene-Related Peptide Receptor Antagonist for the Treatment of Migraine

2007 ◽  
Vol 324 (2) ◽  
pp. 416-421 ◽  
Author(s):  
Christopher A. Salvatore ◽  
James C. Hershey ◽  
Halea A. Corcoran ◽  
John F. Fay ◽  
Victor K. Johnston ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Calcitonin Gene Related Peptide ◽  
Pharmacological Characterization ◽  
Peptide Receptor ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Orally Active

Pharmacological Properties of MK-3207, a Potent and Orally Active Calcitonin Gene-Related Peptide Receptor Antagonist

2010 ◽  
Vol 333 (1) ◽  
pp. 152-160 ◽  
Author(s):  
Christopher A. Salvatore ◽  
Eric L. Moore ◽  
Amy Calamari ◽  
Jacquelynn J. Cook ◽  
Maria S. Michener ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Calcitonin Gene Related Peptide ◽  
Pharmacological Properties ◽  
Peptide Receptor ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Orally Active

scholarly journals Characterization of the effects of calcitonin gene-related peptide receptor antagonist for Alzheimer's disease

2020 ◽  
Vol 168 ◽  
pp. 108017
Author(s):  
Hana Na ◽  
Qini Gan ◽  
Liam Mcparland ◽  
Jack B. Yang ◽  
Hongbo Yao ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Receptor Antagonist ◽  
Calcitonin Gene Related Peptide ◽  
Peptide Receptor ◽  
Related Peptide ◽  
Calcitonin Gene

scholarly journals Characterization of Ubrogepant: A Potent and Selective Antagonist of the Human Calcitonin Gene‒Related Peptide Receptor*

2020 ◽  
pp. jpet.119.261065 ◽  
Author(s):  
Eric Moore ◽  
Mark E. Fraley ◽  
Ian M. Bell ◽  
Christopher S. Burgey ◽  
Rebecca B. White ◽  
...  
Keyword(s):  
Calcitonin Gene Related Peptide ◽  
Human Calcitonin ◽  
Peptide Receptor ◽  
Selective Antagonist ◽  
Related Peptide ◽  
Calcitonin Gene

Asymmetric Synthesis of the Major Metabolite of a Calcitonin Gene-Related Peptide Receptor Antagonist and Mechanism of Epoxide Hydrogenolysis

2017 ◽  
Vol 82 (7) ◽  
pp. 3710-3720 ◽  
Author(s):  
Guanglin Luo ◽  
Ling Chen ◽  
Charles M. Conway ◽  
Walter Kostich ◽  
Benjamin M. Johnson ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Asymmetric Synthesis ◽  
Calcitonin Gene Related Peptide ◽  
Major Metabolite ◽  
Peptide Receptor ◽  
Related Peptide ◽  
Calcitonin Gene

scholarly journals Characterizing the PK/PD relationship for inhibition of capsaicin-induced dermal vasodilatation by MK-3207, an oral calcitonin gene related peptide receptor antagonist

2015 ◽  
Vol 79 (5) ◽  
pp. 831-837 ◽  
Author(s):  
Chi-Chung Li ◽  
Steve Vermeersch ◽  
William S. Denney ◽  
William P. Kennedy ◽  
John Palcza ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Calcitonin Gene Related Peptide ◽  
Peptide Receptor ◽  
Related Peptide ◽  
Calcitonin Gene
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