Asymmetric Synthesis of the Major Metabolite of a Calcitonin Gene-Related Peptide Receptor Antagonist and Mechanism of Epoxide Hydrogenolysis

Major Metabolite ◽

Peptide Receptor ◽

Related Peptide ◽

Pharmacological Properties of MK-3207, a Potent and Orally Active Calcitonin Gene-Related Peptide Receptor Antagonist

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.109.163816 ◽

2010 ◽

Vol 333 (1) ◽

pp. 152-160 ◽

Cited By ~ 52

Author(s):

Christopher A. Salvatore ◽

Eric L. Moore ◽

Amy Calamari ◽

Jacquelynn J. Cook ◽

Maria S. Michener ◽

...

Keyword(s):

Receptor Antagonist ◽

Pharmacological Properties ◽

Peptide Receptor ◽

Related Peptide ◽

Calcitonin Gene ◽

Orally Active

Comparison of the Vasoconstrictor Effects of the Calcitonin Gene-related Peptide Receptor Antagonist Telcagepant (MK-0974) and Zolmitriptan in Human Isolated Coronary Arteries

Journal of Cardiovascular Pharmacology ◽

10.1097/fjc.0b013e3181d7665f ◽

2010 ◽

Vol 55 (5) ◽

pp. 518-521 ◽

Cited By ~ 5

Author(s):

Joseph J Lynch ◽

Christopher P Regan ◽

Lars Edvinsson ◽

Richard J Hargreaves ◽

Stefanie A Kane

Keyword(s):

Receptor Antagonist ◽

Coronary Arteries ◽

Peptide Receptor ◽

Related Peptide ◽

An oral calcitonin gene-related peptide receptor antagonist for acute migraine management: Sign of a possible new chapter in headache medicine

Current Neurology and Neuroscience Reports ◽

10.1007/s11910-009-0014-9 ◽

2009 ◽

Vol 9 (2) ◽

pp. 91-93

Author(s):

Ivan Garza

Keyword(s):

Receptor Antagonist ◽

Acute Migraine ◽

Peptide Receptor ◽

Related Peptide ◽

Characterization of the effects of calcitonin gene-related peptide receptor antagonist for Alzheimer's disease

Neuropharmacology ◽

10.1016/j.neuropharm.2020.108017 ◽

2020 ◽

Vol 168 ◽

pp. 108017

Author(s):

Hana Na ◽

Qini Gan ◽

Liam Mcparland ◽

Jack B. Yang ◽

Hongbo Yao ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Receptor Antagonist ◽

Peptide Receptor ◽

Related Peptide ◽

The Nonpeptide Calcitonin Gene-Related Peptide Receptor Antagonist BIBN4096BS Lowers the Activity of Neurons with Meningeal Input in the Rat Spinal Trigeminal Nucleus

Journal of Neuroscience ◽

10.1523/jneurosci.0869-05.2005 ◽

2005 ◽

Vol 25 (25) ◽

pp. 5877-5883 ◽

Cited By ~ 102

Author(s):

M. J. M. Fischer

Keyword(s):

Receptor Antagonist ◽

Spinal Trigeminal Nucleus ◽

Trigeminal Nucleus ◽

Peptide Receptor ◽

Related Peptide ◽

Characterizing the PK/PD relationship for inhibition of capsaicin-induced dermal vasodilatation by MK-3207, an oral calcitonin gene related peptide receptor antagonist

British Journal of Clinical Pharmacology ◽

10.1111/bcp.12547 ◽

2015 ◽

Vol 79 (5) ◽

pp. 831-837 ◽

Cited By ~ 13

Author(s):

Chi-Chung Li ◽

Steve Vermeersch ◽

William S. Denney ◽

William P. Kennedy ◽

John Palcza ◽

...

Keyword(s):

Receptor Antagonist ◽

Peptide Receptor ◽

Related Peptide ◽

Calcitonin Gene-Related Peptide Receptor Antagonist Found Safe and Effective for Migraine

Neurology Today ◽

10.1097/01.nt.0000323907.86624.c7 ◽

2008 ◽

Vol 8 (9) ◽

pp. 5-6

Author(s):

KURT SAMSON

Keyword(s):

Receptor Antagonist ◽

Peptide Receptor ◽

Related Peptide ◽

Synthesis of the (3R,6S)-3-Amino-6-(2,3-difluorophenyl)azepan-2-one of Telcagepant (MK-0974), a Calcitonin Gene-Related Peptide Receptor Antagonist for the Treatment of Migraine Headache

Organic Letters ◽

10.1021/ol8011524 ◽

2008 ◽

Vol 10 (15) ◽

pp. 3235-3238 ◽

Cited By ~ 45

Author(s):

Christopher S. Burgey ◽

Daniel V. Paone ◽

Anthony W. Shaw ◽

James Z. Deng ◽

Diem N. Nguyen ◽

...

Keyword(s):

Receptor Antagonist ◽

Migraine Headache ◽

Peptide Receptor ◽

Related Peptide ◽

Pharmacological Characterization of MK-0974 [N-[(3R,6S)-6-(2,3-Difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide], a Potent and Orally Active Calcitonin Gene-Related Peptide Receptor Antagonist for the Treatment of Migraine

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.107.130344 ◽

2007 ◽

Vol 324 (2) ◽

pp. 416-421 ◽

Cited By ~ 114

Author(s):

Christopher A. Salvatore ◽

James C. Hershey ◽

Halea A. Corcoran ◽

John F. Fay ◽

Victor K. Johnston ◽

...

Keyword(s):

Receptor Antagonist ◽

Pharmacological Characterization ◽

Peptide Receptor ◽

Related Peptide ◽

Calcitonin Gene ◽

Orally Active

Erenumab: A novel calcitonin gene-related peptide receptor antagonist developed specifically for migraine prevention

Journal of Anaesthesiology Clinical Pharmacology ◽

10.4103/joacp.joacp_3_19 ◽

2020 ◽

Vol 36 (1) ◽

pp. 104

Author(s):

Shuchita Garg ◽

Malti Vij ◽

Neeraj Edward ◽

Brinder Vij

Keyword(s):

Receptor Antagonist ◽

Migraine Prevention ◽

Peptide Receptor ◽

Related Peptide ◽