Calcitonin Gene-Related Peptide Selectively Relaxes Contractile Responses to Endothelin-1 in Rat Mesenteric Resistance Arteries

2009 ◽  
Vol 331 (1) ◽  
pp. 87-95 ◽  
Author(s):  
Merlijn J. P. M. T. Meens ◽  
Gregorio E. Fazzi ◽  
Marc A. van Zandvoort ◽  
Jo G. R. De Mey
Keyword(s):  
Calcitonin Gene Related Peptide ◽  
Resistance Arteries ◽  
Contractile Responses ◽  
Endothelin 1 ◽  
Related Peptide ◽  
Calcitonin Gene

Mechanisms Leading to Increased Vasodilator Responses to Calcitonin-Gene-Related Peptide in Mesenteric Resistance Arteries of Early Pregnant Rats

2008 ◽  
Vol 45 (4) ◽  
pp. 350-356 ◽  
Author(s):  
H.W.F. van Eijndhoven ◽  
G.M.J. Janssen ◽  
R. Aardenburg ◽  
M.E.A. Spaanderman ◽  
L.L.H. Peeters ◽  
...  
Keyword(s):  
Calcitonin Gene Related Peptide ◽  
Resistance Arteries ◽  
Pregnant Rats ◽  
Related Peptide ◽  
Calcitonin Gene

Effect of chronic sensory denervation on Ca2+-induced relaxation of isolated mesenteric resistance arteries

1998 ◽  
Vol 274 (5) ◽  
pp. H1655-H1661 ◽  
Author(s):  
Maria M. Mupanomunda ◽  
Yanlin Wang ◽  
Richard D. Bukoski
Keyword(s):  
Calcitonin Gene Related Peptide ◽  
Relaxation Response ◽  
Resistance Arteries ◽  
Related Peptide ◽  
Density Control ◽  
Calcitonin Gene ◽  
Perivascular Nerves ◽  
Sensory Denervation ◽  
Immunocytochemical Studies ◽  
Dose Dependent

We recently reported that Ca2+-induced relaxation could be linked to a Ca2+ receptor (CaR) present in perivascular nerves. The present study assessed the effect of chronic sensory denervation on Ca2+-induced relaxation. Mesenteric resistance arteries were isolated from rats treated as neonates with capsaicin (50 mg/kg), vehicle, or saline. The effect of cumulative addition of Ca2+ was assessed in vessels precontracted with 5 μM norepinephrine. Immunocytochemical studies showed that capsaicin treatment significantly reduced the density of nerves staining positively for calcitonin gene-related peptide (CGRP) and for the CaR (CGRP density: control, 51.1 ± 3.9 μm2/mm2; capsaicin treated, 31.4 ± 2.8 μm2/mm2, P = 0.01; control CaR density, 46 ± 4 μm2/mm2, n = 7; capsaicin-treated CaR density, 24 ± 4 μm2/mm2, n = 8, P = 0.002). Dose-dependent relaxation to Ca2+ (1–5 mM) was significantly depressed in vessels from capsaicin-treated rats (overall P < 0.001, n = 6 or 7), whereas the relaxation response to acetylcholine remained intact. These data support the hypothesis that Ca2+-induced relaxation is mediated by activation of the CaR associated with capsaicin-sensitive perivascular neurons.

Calcitonin gene-related peptide, endothelin-1, the cutaneous microvasculature and Raynaud's phenomenon

1996 ◽  
Vol 134 (3) ◽  
pp. 399-406 ◽  
Author(s):  
C. B. BUNKER ◽  
P. C. GOLDSMITH ◽  
T. A. LESLIE ◽  
N. HAYES ◽  
J. C. FOREMAN ◽  
...  
Keyword(s):  
Raynaud’S Phenomenon ◽  
Raynaud's Phenomenon ◽  
Calcitonin Gene Related Peptide ◽  
Endothelin 1 ◽  
Related Peptide ◽  
Calcitonin Gene
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