Re: Yamashita J, Itoh M, Kuro T, Kobayashi Y, Ogata M, Takaoka M, and Matsumura Y (2001) Pre- or Post-Ischemic Treatment with a Novel Na+/Ca2+ Exchange Inhibitor, KB-R7943, Shows Renal Protective Effects in Rats with Ischemic Acute Renal Failure. J Pharmacol Exp Ther 296:412–419

2014 ◽  
Vol 349 (2) ◽  
pp. 344-344
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Protective Effects ◽  
Exchange Inhibitor ◽  
Ischemic Acute Renal Failure

scholarly journals Protective effect of KB-R7943, a novel Na+/Ca2+ exchange inhibitor, on ischemic acute renal failure in rats

2000 ◽  
Vol 82 ◽  
pp. 70
Author(s):  
Junji Yamashita ◽  
Tosihiko Kuro ◽  
Makoto Itoh ◽  
Yutaka Kobayashi ◽  
Masanori Takaoka ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Protective Effect ◽  
Exchange Inhibitor ◽  
Ischemic Acute Renal Failure

scholarly journals Simultaneous blockade of endothelin A and B receptors in ischemic acute renal failure is detrimental to long-term kidney function

2001 ◽  
Vol 59 (4) ◽  
pp. 1333-1341 ◽  
Author(s):  
Josephine Maree Forbes ◽  
Timothy David Hewitson ◽  
Gavin James Becker ◽  
Colin Lindsay Jones
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Kidney Function ◽  
Endothelin A ◽  
Ischemic Acute Renal Failure

Oestrogen protects against ischaemic acute renal failure in rats by suppressing renal endothelin-1 overproduction

2002 ◽  
Vol 103 (s2002) ◽  
pp. 434S-437S ◽  
Author(s):  
Masanori TAKAOKA ◽  
Mikihiro YUBA ◽  
Toshihide FUJII ◽  
Mamoru OHKITA ◽  
Yasuo MATSUMURA
Keyword(s):  
Renal Failure ◽  
Renal Function ◽  
Acute Renal Failure ◽  
Renal Dysfunction ◽  
Tissue Injury ◽  
Male Rats ◽  
Left Renal Artery ◽  
Protective Effects ◽  
Endothelin 1 ◽  
Ischaemia Reperfusion

We investigated whether the treatment with 17β-oestradiol has renal protective effects in male rats with ischaemic acute renal failure (ARF). We also examined if the effect of 17β-oestradiol is accompanied by suppression of enhanced endothelin-1 production in postischaemic kidneys. Ischaemic ARF was induced by clamping the left renal artery and vein for 45min followed by reperfusion, 2 weeks after contralateral nephrectomy. Renal function parameters such as blood urea nitrogen, plasma creatinine and creatinine clearance were measured to test the effectiveness of the steroid hormone. Renal function in ARF rats markedly decreased 24h after reperfusion. The ischaemia/reperfusion-induced renal dysfunction was dose-dependently improved by pretreatment with 17β-oestradiol (20 or 100µg/kg, intravenously). Histopathological examination of the kidney of untreated ARF rats revealed severe lesions, such as tubular necrosis, proteinaceous casts in tubuli and medullary congestion, all of which were markedly improved by the higher dose of 17β-oestradiol. In addition, endothelin-1 content in the kidney after the ischaemia/reperfusion increased significantly by approx. 2-fold over sham-operated rats, and this elevation was dose-dependently suppressed by the 17β-oestradiol treatment. These results suggest that oestrogen exhibits protective effects against renal dysfunction and tissue injury induced by ischaemia/reperfusion, possibly through the suppression of endothelin-1 overproduction in postischaemic kidneys.

Effect of Ringer Infusion on Ischemic Acute Renal Failure: Caution on Interpreting the Results of Short-Term Studies

Renal Failure ◽  
1991 ◽  
Vol 13 (1) ◽  
pp. 5-13
Author(s):  
Terrance A. Fried ◽  
Akira Hishida ◽  
Mary Alice Ayon ◽  
Jeffrey L. Barnes ◽  
Jay H. Stein
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Short Term ◽  
Ischemic Acute Renal Failure
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