GSK356278, a Potent, Selective, Brain-Penetrant Phosphodiesterase 4 Inhibitor That Demonstrates Anxiolytic and Cognition-Enhancing Effects without Inducing Side Effects in Preclinical Species

2014 ◽  
Vol 350 (1) ◽  
pp. 153-163 ◽  
Author(s):  
A. Richard Rutter ◽  
Alessandro Poffe ◽  
Palmina Cavallini ◽  
T. Gregg Davis ◽  
Jessica Schneck ◽  
...  
Keyword(s):  
Side Effects ◽  
Phosphodiesterase 4 ◽  
Preclinical Species ◽  
Phosphodiesterase 4 Inhibitor

Disposition of CP-671, 305, a selective phosphodiesterase 4 inhibitor in preclinical species

Xenobiotica ◽  
2004 ◽  
Vol 34 (8) ◽  
pp. 755-770 ◽  
Author(s):  
A. S. Kalgutkar ◽  
E. Choo ◽  
T. J. Taylor ◽  
A. Marfat
Keyword(s):  
Phosphodiesterase 4 ◽  
Preclinical Species ◽  
Phosphodiesterase 4 Inhibitor

Zeitverlauf und Reversibilität der Gewichtsabnahme unter Roflumilast, einem oralen, selektiven Phosphodiesterase 4 Inhibitor

Pneumologie ◽  
2011 ◽  
Vol 65 (S 01) ◽  
Author(s):  
H Trauth ◽  
H Steffen ◽  
U Gehling ◽  
C Faouzi ◽  
C Vogelmeier ◽  
...  
Keyword(s):  
Phosphodiesterase 4 ◽  
Phosphodiesterase 4 Inhibitor

scholarly journals Lack of Clinical Efficacy of a Phosphodiesterase-4 Inhibitor for Treatment of Heaves in Horses

2006 ◽  
Vol 20 (1) ◽  
pp. 175-181 ◽  
Author(s):  
Jean-Pierre Lavoie ◽  
Kirby Pasloske ◽  
Philippe Joubert ◽  
Marie-Eve Cordeau ◽  
Joseph Mancini ◽  
...  
Keyword(s):  
Clinical Efficacy ◽  
Phosphodiesterase 4 ◽  
Phosphodiesterase 4 Inhibitor

Zl-n-91, a selective phosphodiesterase 4 inhibitor, suppresses inflammatory response in a COPD-like rat model

2010 ◽  
Vol 10 (2) ◽  
pp. 252-258 ◽  
Author(s):  
Ya-juan Wang ◽  
Ya-li Jiang ◽  
Hui-fang Tang ◽  
Chun-zhen Zhao ◽  
Ji-qiang Chen
Keyword(s):  
Inflammatory Response ◽  
Rat Model ◽  
Phosphodiesterase 4 ◽  
Phosphodiesterase 4 Inhibitor
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