Mashiningan Improves Opioid-Induced Constipation in Rats by Activating Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel

Yumi Harada; Seiichi Iizuka; Yayoi Saegusa; Sachiko Mogami; Naoki Fujitsuka; Tomohisa Hattori

doi:10.1124/jpet.117.240630

Mashiningan Improves Opioid-Induced Constipation in Rats by Activating Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.117.240630 ◽

2017 ◽

Vol 362 (1) ◽

pp. 78-84 ◽

Cited By ~ 10

Author(s):

Yumi Harada ◽

Seiichi Iizuka ◽

Yayoi Saegusa ◽

Sachiko Mogami ◽

Naoki Fujitsuka ◽

...

Keyword(s):

Cystic Fibrosis ◽

Chloride Channel ◽

Transmembrane Conductance Regulator ◽

Transmembrane Conductance ◽

Cystic Fibrosis Transmembrane

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Emerging role of cystic fibrosis transmembrane conductance regulator - an epithelial chloride channel in gastrointestinal cancers

World Journal of Gastrointestinal Oncology ◽

10.4251/wjgo.v8.i3.282 ◽

2016 ◽

Vol 8 (3) ◽

pp. 282 ◽

Cited By ~ 17

Author(s):

Yuning Hou ◽

Xiaoqing Guan ◽

Zhe Yang ◽

Chunying Li

Keyword(s):

Cystic Fibrosis ◽

Chloride Channel ◽

Transmembrane Conductance Regulator ◽

Gastrointestinal Cancers ◽

Transmembrane Conductance ◽

Cystic Fibrosis Transmembrane

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Molecular Determinants of Anion Selectivity in the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Pore

Biophysical Journal ◽

10.1016/s0006-3495(00)76836-6 ◽

2000 ◽

Vol 78 (6) ◽

pp. 2973-2982 ◽

Cited By ~ 69

Author(s):

Paul Linsdell ◽

Alexandra Evagelidis ◽

John W. Hanrahan

Keyword(s):

Cystic Fibrosis ◽

Chloride Channel ◽

Transmembrane Conductance Regulator ◽

Transmembrane Conductance ◽

Channel Pore ◽

Anion Selectivity ◽

Molecular Determinants ◽

Cystic Fibrosis Transmembrane

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Changes in the R‐region interactions depend on phosphorylation and contribute to PKA and PKC regulation of the cystic fibrosis transmembrane conductance regulator chloride channel

FASEB BioAdvances ◽

10.1096/fba.2019-00053 ◽

2019 ◽

Vol 2 (1) ◽

pp. 33-48

Author(s):

Diogo R. Poroca ◽

Noha Amer ◽

Audrey Li ◽

John W. Hanrahan ◽

Valerie M. Chappe

Keyword(s):

Cystic Fibrosis ◽

Chloride Channel ◽

Transmembrane Conductance Regulator ◽

Transmembrane Conductance ◽

R Region ◽

Cystic Fibrosis Transmembrane

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Cyanoquinolines with Independent Corrector and Potentiator Activities Restore ΔPhe508-Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Function in Cystic Fibrosis

Molecular Pharmacology ◽

10.1124/mol.111.073056 ◽

2011 ◽

Vol 80 (4) ◽

pp. 683-693 ◽

Cited By ~ 43

Author(s):

Puay-Wah Phuan ◽

Baoxue Yang ◽

John M. Knapp ◽

Alex B. Wood ◽

Gergely L. Lukacs ◽

...

Keyword(s):

Cystic Fibrosis ◽

Chloride Channel ◽

Transmembrane Conductance Regulator ◽

Transmembrane Conductance ◽

Channel Function ◽

Cystic Fibrosis Transmembrane

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The CLIC1 Chloride Channel Is Regulated by the Cystic Fibrosis Transmembrane Conductance Regulator when Expressed in Xenopus Oocytes

The Journal of Membrane Biology ◽

10.1007/s00232-006-0059-5 ◽

2006 ◽

Vol 213 (1) ◽

pp. 39-46 ◽

Cited By ~ 11

Author(s):

John C. Edwards

Keyword(s):

Cystic Fibrosis ◽

Chloride Channel ◽

Xenopus Oocytes ◽

Transmembrane Conductance Regulator ◽

Transmembrane Conductance ◽

Cystic Fibrosis Transmembrane

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Relationship between anion binding and anion permeability revealed by mutagenesis within the cystic fibrosis transmembrane conductance regulator chloride channel pore

The Journal of Physiology ◽

10.1111/j.1469-7793.2001.0051j.x ◽

2001 ◽

Vol 531 (1) ◽

pp. 51-66 ◽

Cited By ~ 61

Author(s):

Paul Linsdell

Keyword(s):

Cystic Fibrosis ◽

Chloride Channel ◽

Anion Binding ◽

Transmembrane Conductance Regulator ◽

Transmembrane Conductance ◽

Channel Pore ◽

Anion Permeability ◽

Cystic Fibrosis Transmembrane

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Targeted Inactivation of Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Gene Prevents Ischemic Preconditioning in Isolated Mouse Heart

Circulation ◽

10.1161/01.cir.0000138110.84758.bb ◽

2004 ◽

Vol 110 (6) ◽

pp. 700-704 ◽

Cited By ~ 31

Author(s):

Hong Chen ◽

Luis L. Liu ◽

Linda L. Ye ◽

Conor McGuckin ◽

Susan Tamowski ◽

...

Keyword(s):

Cystic Fibrosis ◽

Ischemic Preconditioning ◽

Chloride Channel ◽

Mouse Heart ◽

Transmembrane Conductance Regulator ◽

Transmembrane Conductance ◽

Channel Gene ◽

Cystic Fibrosis Transmembrane ◽

Targeted Inactivation

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Direct Comparison of the Functional Roles Played by Different Transmembrane Regions in the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Pore

Journal of Biological Chemistry ◽

10.1074/jbc.m411935200 ◽

2004 ◽

Vol 279 (53) ◽

pp. 55283-55289 ◽

Cited By ~ 50

Author(s):

Ning Ge ◽

Chantal N. Muise ◽

Xiandi Gong ◽

Paul Linsdell

Keyword(s):

Cystic Fibrosis ◽

Chloride Channel ◽

Transmembrane Conductance Regulator ◽

Transmembrane Conductance ◽

Channel Pore ◽

Functional Roles ◽

Transmembrane Regions ◽

Cystic Fibrosis Transmembrane

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Mo1572 - Activation of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Chloride Channel by Cannabidis Semen , a Component of Mashiningan, Contributes to Improvement of Opioid-Induced Constipation in Rats

Gastroenterology ◽

10.1016/s0016-5085(18)32623-4 ◽

2018 ◽

Vol 154 (6) ◽

pp. S-756-S-757

Author(s):

Yumi Harada ◽

Seiichi Iizuka ◽

Hitomi Sekine ◽

Naoki Fujitsuka

Keyword(s):

Cystic Fibrosis ◽

Chloride Channel ◽

Transmembrane Conductance Regulator ◽

Transmembrane Conductance ◽

Cystic Fibrosis Transmembrane

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Role of the Juxtamembrane Region of Cytoplasmic Loop 3 in the Gating and Conductance of the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel

Biochemistry ◽

10.1021/bi300065z ◽

2012 ◽

Vol 51 (19) ◽

pp. 3971-3981 ◽

Cited By ~ 7

Author(s):

Yassine El Hiani ◽

Paul Linsdell

Keyword(s):

Cystic Fibrosis ◽

Chloride Channel ◽

Transmembrane Conductance Regulator ◽

Transmembrane Conductance ◽

Cytoplasmic Loop ◽

Juxtamembrane Region ◽

Cystic Fibrosis Transmembrane

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