(-)-7′-Isothiocyanato-11-hydroxy-1′,1′-dimethylheptylhexahydrocannabinol (AM841), a High-Affinity Electrophilic Ligand, Interacts Covalently with a Cysteine in Helix Six and Activates the CB1 Cannabinoid Receptor

2005 ◽  
Vol 68 (6) ◽  
pp. 1623-1635 ◽  
Author(s):  
Robert P. Picone ◽  
Atmaram D. Khanolkar ◽  
Wei Xu ◽  
Lionel A. Ayotte ◽  
Ganesh A. Thakur ◽  
...  
Keyword(s):  
Cannabinoid Receptor ◽  
High Affinity ◽  
Cb1 Cannabinoid Receptor

scholarly journals Probing the CB1 Cannabinoid Receptor Binding Pocket with AM6538, a High-Affinity Irreversible Antagonist

2019 ◽  
Vol 96 (5) ◽  
pp. 619-628
Author(s):  
Robert B. Laprairie ◽  
Kiran Vemuri ◽  
Edward L. Stahl ◽  
Anisha Korde ◽  
Jo-Hao Ho ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Cannabinoid Receptor ◽  
Binding Pocket ◽  
High Affinity ◽  
Cb1 Cannabinoid Receptor

Falcarinol (Panaxynol) is a CB1 cannabinoid receptor antagonist and induces pro-allergic effects in skin

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
J Gertsch ◽  
M Leonti ◽  
L Casu ◽  
F Cottiglia ◽  
S Raduner ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Cannabinoid Receptor ◽  
Cb1 Cannabinoid Receptor

scholarly journals Tricyclic Pyrazole-Based Compounds as Useful Scaffolds for Cannabinoid CB1/CB2 Receptor Interaction

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2126
Author(s):  
Battistina Asproni ◽  
Gabriele Murineddu ◽  
Paola Corona ◽  
Gérard A. Pinna
Keyword(s):  
Neuropathic Pain ◽  
Cannabinoid Receptor ◽  
Receptor Interaction ◽  
Pharmacological Properties ◽  
Cb2 Receptor ◽  
Antiemetic Effect ◽  
High Affinity ◽  
Cb1 Antagonist ◽  
Cb2 Receptors ◽  
Sar Study

Cannabinoids comprise different classes of compounds, which aroused interest in recent years because of their several pharmacological properties. Such properties include analgesic activity, bodyweight reduction, the antiemetic effect, the reduction of intraocular pressure and many others, which appear correlated to the affinity of cannabinoids towards CB1 and/or CB2 receptors. Within the search aiming to identify novel chemical scaffolds for cannabinoid receptor interaction, the CB1 antagonist/inverse agonist pyrazole-based derivative rimonabant has been modified, giving rise to several tricyclic pyrazole-based compounds, most of which endowed of high affinity and selectivity for CB1 or CB2 receptors. The aim of this review is to present the synthesis and summarize the SAR study of such tricyclic pyrazole-based compounds, evidencing, for some derivatives, their potential in the treatment of neuropathic pain, obesity or in the management of glaucoma.

scholarly journals The CB1 cannabinoid receptor mediates excitotoxicity-induced neural progenitor proliferation and neurogenesis. VOLUME 282 (2007) PAGES 23892-23898

2008 ◽  
Vol 283 (9) ◽  
pp. 5971
Author(s):  
Tania Aguado ◽  
Eva Romero ◽  
Krisztina Monory ◽  
Javier Palazuelos ◽  
Michael Sendtner ◽  
...  
Keyword(s):  
Cannabinoid Receptor ◽  
Neural Progenitor ◽  
Cb1 Cannabinoid Receptor

Design, synthesis and biological evaluation of piperazine analogues as CB1 cannabinoid receptor ligands

2008 ◽  
Vol 16 (7) ◽  
pp. 4035-4051 ◽  
Author(s):  
Kwang-Seop Song ◽  
Sung-Han Lee ◽  
Hyun Ji Chun ◽  
Jong Yup Kim ◽  
Myung Eun Jung ◽  
...  
Keyword(s):  
Cannabinoid Receptor ◽  
Biological Evaluation ◽  
Receptor Ligands ◽  
Design Synthesis ◽  
Cb1 Cannabinoid Receptor ◽  
Synthesis And Biological Evaluation
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