Species Selectivity of a Nicotinic Acetylcholine Receptor Agonist Is Conferred by Two Adjacent Extracellular β4 Amino Acids that Are Implicated in the Coupling of Binding to Channel Gating

Receptor Agonist ◽

Channel Gating ◽

Nicotinic Acetylcholine ◽

Species Selectivity

Identification of Amino Acids in the Nicotinic Acetylcholine Receptor Agonist Binding Site and Ion Channel Photolabeled by 4-[(3-Trifluoromethyl)-3H-Diazirin-3-yl]Benzoylcholine, a Novel Photoaffinity Antagonist†

Biochemistry ◽

10.1021/bi0269815 ◽

2003 ◽

Vol 42 (2) ◽

pp. 271-283 ◽

Cited By ~ 14

Author(s):

David C. Chiara ◽

Jonathan C. Trinidad ◽

Dong Wang ◽

Michael R. Ziebell ◽

Deirdre Sullivan ◽

...

Keyword(s):

Amino Acids ◽

Ion Channel ◽

Binding Site ◽

Acetylcholine Receptor ◽

Receptor Agonist ◽

Agonist Binding ◽

Epibatidine, a nicotinic acetylcholine receptor agonist, inhibits the capsaicin response in dorsal root ganglion neurons

Brain Research ◽

10.1016/s0006-8993(01)03028-1 ◽

2001 ◽

Vol 919 (1) ◽

pp. 166-168 ◽

Cited By ~ 3

Author(s):

Xu-Feng Zhang ◽

David G. McKenna ◽

Clark A. Briggs

Keyword(s):

Dorsal Root Ganglion ◽

Acetylcholine Receptor ◽

Dorsal Root ◽

Receptor Agonist ◽

Dorsal Root Ganglion Neurons ◽

Nicotinic Acetylcholine ◽

Ganglion Neurons

Protein-ligand interactions. 6 nicotinic acetylcholine receptor agonist activity of isoquinoline alkaloids

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(96)00429-5 ◽

1996 ◽

Vol 6 (23) ◽

pp. 2801-2806 ◽

Cited By ~ 5

Author(s):

C.G. Whiteley ◽

S. Daya

Keyword(s):

Acetylcholine Receptor ◽

Receptor Agonist ◽

Agonist Activity ◽

Isoquinoline Alkaloids ◽

Nicotinic Acetylcholine ◽

Protein Ligand Interactions ◽

Ligand Interactions

In Vitro Pharmacological Characterization of a Novel Selective α7 Neuronal Nicotinic Acetylcholine Receptor Agonist ABT-107

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.110.167072 ◽

2010 ◽

Vol 334 (3) ◽

pp. 863-874 ◽

Cited By ~ 40

Author(s):

John Malysz ◽

David J. Anderson ◽

Jens H. Grønlien ◽

Jianguo Ji ◽

William H. Bunnelle ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Receptor Agonist ◽

Neuronal Nicotinic Acetylcholine Receptor ◽

Pharmacological Characterization ◽

P4-310: Preclinical characterization of a selective alpha-7 neuronal nicotinic acetylcholine receptor agonist ABT-126: A novel therapeutic agent for the treatment of cognitive impairment in Alzheimer's disease and schizophrenia

Alzheimer s & Dementia ◽

10.1016/j.jalz.2013.05.1755 ◽

2013 ◽

Vol 9 ◽

pp. P817-P818 ◽

Cited By ~ 5

Author(s):

Robert Bitner ◽

David Anderson ◽

Karla Drescher ◽

Kathy Kohlhaas ◽

Halvard Gronlien ◽

...

Keyword(s):

Cognitive Impairment ◽

Acetylcholine Receptor ◽

Receptor Agonist ◽

Therapeutic Agent ◽

Neuronal Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Alpha 7 ◽

Novel Therapeutic

Monocytes primed with GTS-21/α7 nAChR (nicotinic acetylcholine receptor) agonist develop anti-inflammatory memory

QJM ◽

10.1093/qjmed/hcx014 ◽

2017 ◽

pp. hcx014 ◽

Cited By ~ 2

Author(s):

Xi Yang ◽

Caiqi Zhao ◽

Xiu Chen ◽

Lubin Jiang ◽

Xiao Su

Keyword(s):

Acetylcholine Receptor ◽

Receptor Agonist ◽

Nicotinic Acetylcholine ◽

Α7 Nachr ◽

Anti Inflammatory

Efficacy and Safety of the α7-Nicotinic Acetylcholine Receptor Agonist ABT-126 in the Treatment of Cognitive Impairment Associated With Schizophrenia

The Journal of Clinical Psychiatry ◽

10.4088/jcp.16m11162 ◽

2018 ◽

Vol 79 (3) ◽

Cited By ~ 3

Author(s):

George M. Haig ◽

Deli Wang ◽

Jun Zhao ◽

Ahmed A. Othman ◽

Earle E. Bain

Keyword(s):

Cognitive Impairment ◽

Acetylcholine Receptor ◽

Receptor Agonist ◽

Efficacy And Safety ◽

Α7 Nicotinic Acetylcholine Receptor ◽

The α7 nicotinic acetylcholine receptor agonist, GTS-21, attenuates hyperoxia-induced acute inflammatory lung injury by alleviating the accumulation of HMGB1 in the airways and the circulation

Molecular Medicine ◽

10.1186/s10020-020-00177-z ◽

2020 ◽

Vol 26 (1) ◽

Cited By ~ 2

Author(s):

Ravikumar A. Sitapara ◽

Alex G. Gauthier ◽

Sergio I. Valdés-Ferrer ◽

Mosi Lin ◽

Vivek Patel ◽

...

Keyword(s):

Lung Injury ◽

Acetylcholine Receptor ◽

Receptor Agonist ◽

Α7 Nicotinic Acetylcholine Receptor ◽

In vivo and in vitro studies of Cry5B and nicotinic acetylcholine receptor agonist anthelmintics reveal a powerful and unique combination therapy against intestinal nematode parasites

PLoS Neglected Tropical Diseases ◽

10.1371/journal.pntd.0006506 ◽

2018 ◽

Vol 12 (5) ◽

pp. e0006506 ◽

Cited By ~ 4

Author(s):

Yan Hu ◽

Melanie Miller ◽

Bo Zhang ◽

Thanh-Thanh Nguyen ◽

Martin K. Nielsen ◽

...

Keyword(s):

Combination Therapy ◽

Acetylcholine Receptor ◽

Receptor Agonist ◽

Unique Combination ◽

Nicotinic Acetylcholine ◽

Intestinal Nematode ◽

Nematode Parasites

Enhancement of sustained attention performance by the nicotinic acetylcholine receptor agonist ABT-418 in intact but not basal forebrain-lesioned rats

Psychopharmacology ◽

10.1007/s002130050991 ◽

1999 ◽

Vol 144 (2) ◽

pp. 175-182 ◽

Cited By ~ 95

Author(s):

J. McGaughy ◽

M. W. Decker ◽

M. Sarter

Keyword(s):

Acetylcholine Receptor ◽

Sustained Attention ◽

Basal Forebrain ◽

Receptor Agonist ◽

Nicotinic Acetylcholine ◽

Attention Performance