scholarly journals [3H]Org 43553, the First Low-Molecular-Weight Agonistic and Allosteric Radioligand for the Human Luteinizing Hormone Receptor

2007 ◽  
Vol 73 (2) ◽  
pp. 518-524 ◽  
Author(s):  
Laura H. Heitman ◽  
Julia Oosterom ◽  
Kimberly M. Bonger ◽  
Cornelis M. Timmers ◽  
Peter H. G. Wiegerinck ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Luteinizing Hormone ◽  
Hormone Receptor ◽  
Luteinizing Hormone Receptor ◽  
Low Molecular Weight

scholarly journals Induction of ovulation by a potent, orally active, low molecular weight agonist (Org 43553) of the luteinizing hormone receptor

2008 ◽  
Vol 24 (3) ◽  
pp. 640-648 ◽  
Author(s):  
R. van de Lagemaat ◽  
C.M. Timmers ◽  
J. Kelder ◽  
C. van Koppen ◽  
S. Mosselman ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Luteinizing Hormone ◽  
Hormone Receptor ◽  
Luteinizing Hormone Receptor ◽  
Low Molecular Weight ◽  
Induction Of Ovulation ◽  
Orally Active

Corrections to Substituted Terphenyl Compounds as the First Class of Low Molecular Weight Allosteric Inhibitors of the Luteinizing Hormone Receptor

2010 ◽  
Vol 53 (1) ◽  
pp. 520-520
Author(s):  
Laura H. Heitman ◽  
Rajeshwar Narlawar ◽  
Henk de Vries ◽  
Milou N. Willemsen ◽  
Dieter Wolfram ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Luteinizing Hormone ◽  
Hormone Receptor ◽  
Luteinizing Hormone Receptor ◽  
Low Molecular Weight ◽  
Allosteric Inhibitors

Identification of luteinizing hormone receptor binding inhibitor in bovine corpora lutea

1995 ◽  
Vol 132 (2) ◽  
pp. 213-217 ◽  
Author(s):  
Premila Rathnam ◽  
Shou-qing Lin ◽  
Brij B Saxena
Keyword(s):  
Molecular Weight ◽  
Luteinizing Hormone ◽  
Receptor Binding ◽  
Hormone Receptor ◽  
Luteinizing Hormone Receptor ◽  
Low Molecular Weight ◽  
Corpora Lutea ◽  
Molecular Weight Range ◽  
Lh Receptor ◽  
Weight Range

Rathnam P, Lin S, Saxena BB. Identification of luteinizing hormone receptor binding inhibitor in bovine corpora lutea. Eur J Endocrinol 1995;132:213–17. ISSN 0804–4643 A 7000 g supernatant, obtained during the purification of luteinizing hormone (LH) receptor from bovine corpora lutea homogenate, was concentrated by ultrafiltration. The filtrate, containing < 50 000 molecular weight material, exhibited LH receptor binding inhibitor (LH-RBI) activity. The filtrate was ultrafiltered sequentially through Amicon PM-10, PM-30 and UM-2 filters to yield a LH-RBI-containing fraction in the higher molecular weight range of 30 000–10 000 and a LH-RBI-containing fraction in the lower molecular weight range of 10 000–1000. The higher molecular weight LH-RBI fraction was purified on Sephadex G-25 and the lower molecular weight LH-RBI fraction was purified on Sephadex G-50. Both the high- and the low-molecular-weight LH-RBI species inhibited the binding of 125I-labeled human chorionic gonadotropin (hCG) to bovine corpora lutea and to rat Leydig cell membrane receptors. Similarly, the production of testosterone by hCG-stimulated rat Leydig cells was inhibited in a dose–response manner by both the high- and the low-molecular-weight LH-RBI species. The LH-RBI activity in the low-molecular-weight species was stable at 4°C for up to 6 months and at temperatures up to 90°C for 15 mins, whereas the LH-RBI activity of the high-molecular-weight species was stable at 4°C for 15 months and unstable at 60°C after 15 min. The 7000 g supernatant provided a much-needed source to obtain larger than previously reported quantities of LH-RBI for isolation as well as for structure and function studies. Brij B Saxena, Cornell Univ. Medical College, Rm A-267, 1300 York Ave, New York, NY 10021, USA

Substituted Terphenyl Compounds as the First Class of Low Molecular Weight Allosteric Inhibitors of the Luteinizing Hormone Receptor

2009 ◽  
Vol 52 (7) ◽  
pp. 2036-2042 ◽  
Author(s):  
Laura H. Heitman ◽  
Rajeshwar Narlawar ◽  
Henk de Vries ◽  
Milou N. Willemsen ◽  
Dieter Wolfram ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Luteinizing Hormone ◽  
Hormone Receptor ◽  
Luteinizing Hormone Receptor ◽  
Low Molecular Weight ◽  
Allosteric Inhibitors

Identification, synthesis, and biological evaluation of novel pyrazoles as low molecular weight luteinizing hormone receptor agonists

2007 ◽  
Vol 17 (7) ◽  
pp. 2080-2085 ◽  
Author(s):  
Catherine Jorand-Lebrun ◽  
Bill Brondyk ◽  
Jing Lin ◽  
Sharad Magar ◽  
Robert Murray ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Luteinizing Hormone ◽  
Hormone Receptor ◽  
Biological Evaluation ◽  
Luteinizing Hormone Receptor ◽  
Low Molecular Weight ◽  
Receptor Agonists ◽  
Synthesis And Biological Evaluation

In vitro and in vivo studies of functional activity of new low molecular weight agonists of the luteinizing hormone receptor

2016 ◽  
Vol 10 (4) ◽  
pp. 294-300 ◽  
Author(s):  
K. V. Derkach ◽  
D. V. Dar’in ◽  
A. A. Bakhtyukov ◽  
P. S. Lobanov ◽  
A. O. Shpakov
Keyword(s):  
Molecular Weight ◽  
Luteinizing Hormone ◽  
Functional Activity ◽  
Hormone Receptor ◽  
Luteinizing Hormone Receptor ◽  
In Vivo Studies ◽  
Low Molecular Weight
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