scholarly journals International Union of Basic and Clinical Pharmacology. CIX. Differences and Similarities between Human and Rodent Prostaglandin E2 Receptors (EP1–4) and Prostacyclin Receptor (IP): Specific Roles in Pathophysiologic Conditions

2020 ◽  
Vol 72 (4) ◽  
pp. 910-968 ◽  
Author(s):  
Xavier Norel ◽  
Yukihiko Sugimoto ◽  
Gulsev Ozen ◽  
Heba Abdelazeem ◽  
Yasmine Amgoud ◽  
...  
Keyword(s):  
Clinical Pharmacology ◽  
Prostaglandin E2 ◽  
International Union ◽  
Prostacyclin Receptor

Rabbit cortical collecting ducts express a novel prostacyclin receptor

1995 ◽  
Vol 268 (1) ◽  
pp. F145-F154 ◽  
Author(s):  
R. L. Hebert ◽  
L. Regnier ◽  
L. N. Peterson
Keyword(s):  
Prostaglandin E2 ◽  
Calcium Ion ◽  
Collecting Duct ◽  
Ion Concentration ◽  
Cortical Collecting Duct ◽  
Water Conductivity ◽  
Prostacyclin Receptor ◽  
Collecting Ducts ◽  
Intracellular Calcium Ion ◽  
Calcium Ion Concentration

Prostaglandin E2 (PGE2) inhibits vasopressin-stimulated water conductivity (AVP-Lp) and inhibits Na+ reabsorption in the rabbit cortical collecting duct (CCD). Inhibition of Na+ reabsorption is mediated by increased intracellular calcium ion concentration ([Ca2+]i). Prostacyclin (PGI2) has also been shown to inhibit Na+ reabsorption in the CCD. The present studies were designed to examine the effect of the PGI2 agonist, Iloprost (ILP), on AVP-Lp and [Ca2+ in the isolated perfused rabbit CCD and to determine whether ILP activates different receptors than PGE2. ILP and PGE2 each maximally inhibited AVP-Lp equipotently at 10(-7) M. When CCDs were exposed to PGE2 and ILP simultaneously, or if PGE2 was added in the presence of ILP, inhibition of AVP-Lp was additive. Additivity was not observed if the PGI2 agonist, carbaprostacyclin (c-PGI2), was added with ILP, or if the PGE2 agonist, sulprostone, was added with PGE2, or if ILP was added to CCDs preexposed to PGE2. In fura 2-loaded CCD, ILP and PGE2 added separately increased [Ca2+]i. The response to c-PGI2 could be desensitized by prior exposure to ILP. ILP did not cause desensitization to PGE2, but PGE2 could desensitize the CCD to ILP. We conclude that PGI2 inhibits AVP-Lp by activation of a novel IP3 prostacyclin receptor and increases [Ca2+]i by activation of an IP1 prostacyclin receptor in the rabbit CCD. Functional evidence is presented that PGI2 cannot occupy PGE2 receptors and that PGE2 can occupy but cannot activate PGI2 receptors linked to inhibition of AVP-Lp.

scholarly journals International Union of Basic and Clinical Pharmacology. LXXXIV: Leukotriene Receptor Nomenclature, Distribution, and Pathophysiological Functions

2011 ◽  
Vol 63 (3) ◽  
pp. 539-584 ◽  
Author(s):  
Magnus Bäck ◽  
Sven-Erik Dahlén ◽  
Jeffrey M. Drazen ◽  
Jilly F. Evans ◽  
Charles N. Serhan ◽  
...  
Keyword(s):  
Clinical Pharmacology ◽  
International Union ◽  
Leukotriene Receptor

scholarly journals International Union of Basic and Clinical Pharmacology. C. Nomenclature and Properties of Calcium-Activated and Sodium-Activated Potassium Channels

2016 ◽  
Vol 69 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Leonard K. Kaczmarek ◽  
Richard W. Aldrich ◽  
K. George Chandy ◽  
Stephan Grissmer ◽  
Aguan D. Wei ◽  
...  
Keyword(s):  
Clinical Pharmacology ◽  
Potassium Channels ◽  
International Union

scholarly journals International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors

2013 ◽  
Vol 66 (1) ◽  
pp. 1-79 ◽  
Author(s):  
Francoise Bachelerie ◽  
Adit Ben-Baruch ◽  
Amanda M. Burkhardt ◽  
Christophe Combadiere ◽  
Joshua M. Farber ◽  
...  
Keyword(s):  
Clinical Pharmacology ◽  
Chemokine Receptors ◽  
Extended Family ◽  
International Union

International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the Recognition and Nomenclature of G Protein-Coupled Receptor Heteromultimers

2007 ◽  
Vol 59 (1) ◽  
pp. 5-13 ◽  
Author(s):  
Jean-Philippe Pin ◽  
Richard Neubig ◽  
Michel Bouvier ◽  
Lakshmi Devi ◽  
Marta Filizola ◽  
...  
Keyword(s):  
Clinical Pharmacology ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
International Union ◽  
G Protein Coupled

scholarly journals International Union of Basic and Clinical Pharmacology. LXXXIII: Classification of Prostanoid Receptors, Updating 15 Years of Progress

2011 ◽  
Vol 63 (3) ◽  
pp. 471-538 ◽  
Author(s):  
D. F. Woodward ◽  
R. L. Jones ◽  
S. Narumiya
Keyword(s):  
Clinical Pharmacology ◽  
Prostanoid Receptors ◽  
International Union

scholarly journals International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors—An Update

2011 ◽  
Vol 63 (1) ◽  
pp. 1-34 ◽  
Author(s):  
Bertil B. Fredholm ◽  
Adriaan P. IJzerman ◽  
Kenneth A. Jacobson ◽  
Joel Linden ◽  
Christa E. Müller
Keyword(s):  
Clinical Pharmacology ◽  
Adenosine Receptors ◽  
International Union
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