Germ Cell Specification in Mice

Science ◽  
2007 ◽  
Vol 316 (5823) ◽  
pp. 394-396 ◽  
Author(s):  
K. Hayashi ◽  
S. M. C. de Sousa Lopes ◽  
M. A. Surani
Keyword(s):  
Germ Cell ◽  
Cell Specification ◽  
Germ Cell Specification

scholarly journals Not All H3K4 Methylations Are Created Equal: Mll2/COMPASS Dependency in Primordial Germ Cell Specification

2017 ◽  
Vol 65 (3) ◽  
pp. 460-475.e6 ◽  
Author(s):  
Deqing Hu ◽  
Xin Gao ◽  
Kaixiang Cao ◽  
Marc A. Morgan ◽  
Gloria Mas ◽  
...  
Keyword(s):  
Germ Cell ◽  
Primordial Germ Cell ◽  
Cell Specification ◽  
Germ Cell Specification

SET domain-containing protein 5 is required for expression of primordial germ cell specification-associated genes in murine embryonic stem cells

2017 ◽  
Vol 35 (5) ◽  
pp. 247-253 ◽  
Author(s):  
Seung Eun Yu ◽  
Min Seong Kim ◽  
Su Hyung Park ◽  
Byong Chul Yoo ◽  
Kyung Hee Kim ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Germ Cell ◽  
Primordial Germ Cell ◽  
Embryonic Stem ◽  
Set Domain ◽  
Cell Specification ◽  
Murine Embryonic Stem Cells ◽  
Germ Cell Specification

scholarly journals Requirement of Oct3/4 function for germ cell specification

2008 ◽  
Vol 317 (2) ◽  
pp. 576-584 ◽  
Author(s):  
Daiji Okamura ◽  
Yuko Tokitake ◽  
Hitoshi Niwa ◽  
Yasuhisa Matsui
Keyword(s):  
Germ Cell ◽  
Cell Specification ◽  
Germ Cell Specification

scholarly journals Male Germ Cell Specification and Differentiation

2002 ◽  
Vol 2 (5) ◽  
pp. 537-547 ◽  
Author(s):  
Guang-Quan Zhao ◽  
David L. Garbers
Keyword(s):  
Germ Cell ◽  
Male Germ Cell ◽  
Cell Specification ◽  
Germ Cell Specification

Sall4 Is Essential for Mouse Primordial Germ Cell Specification by Suppressing Somatic Cell Program Genes

Stem Cells ◽  
2014 ◽  
Vol 33 (1) ◽  
pp. 289-300 ◽  
Author(s):  
Yasuka L. Yamaguchi ◽  
Satomi S. Tanaka ◽  
Maho Kumagai ◽  
Yuka Fujimoto ◽  
Takeshi Terabayashi ◽  
...  
Keyword(s):  
Germ Cell ◽  
Somatic Cell ◽  
Primordial Germ Cell ◽  
Cell Specification ◽  
Germ Cell Specification ◽  
Mouse Primordial Germ Cell

scholarly journals Resf1 supports embryonic stem cell self-renewal and effective germline entry

2021 ◽  
Author(s):  
Matus Vojtek ◽  
Ian Chambers
Keyword(s):  
Stem Cells ◽  
Germ Cell ◽  
Germ Line ◽  
Primordial Germ Cell ◽  
Embryonic Stem ◽  
Cell Specification ◽  
Self Renewal ◽  
Downstream Target ◽  
Germ Cell Specification

Retroelement silencing factor 1 (Resf1) interacts with the key regulators of mouse embryonic stem cells (ESCs) Oct4 and Nanog, and its absence results in sterility of mice. However, the function of Resf1 in ESCs and germ line specification is poorly understood. In this study, we used Resf1 knockout cell lines to determine the requirements of RESF1 for ESCs self-renewal and for in vitro specification of ESCs into primordial germ cell-like cells (PGCLCs). We found that deletion of Resf1 in ESCs cultured in serum and LIF reduces self-renewal potential whereas episomal expression of RESF1 has a modest positive effect on ESC self-renewal. In addition, RESF1 is not required for the capacity of NANOG and its downstream target ESRRB to drive self-renewal in the absence of LIF. However, Resf1 deletion reduces efficiency of PGCLC differentiation in vitro. These results identify Resf1 as a novel player in the regulation of pluripotent stem cells and germ cell specification.

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