scholarly journals Tenofovir versus Entecavir in Treatment of Chronic Hepatitis B Virus with Severe Acute Exacerbation

2015 ◽  
Vol 59 (6) ◽  
pp. 3168-3173 ◽  
Author(s):  
Chao-Hung Hung ◽  
Tsung-Hui Hu ◽  
Sheng-Nan Lu ◽  
Chuan-Mo Lee ◽  
Chih-Hung Chen ◽  
...  

ABSTRACTTenofovir disoproxil fumarate (TDF) and entecavir (ETV) are effective antivirals recommended as first-line monotherapies for treatment of chronic hepatitis B (CHB) infection. This study aimed to compare the short-term efficacies of TDF and ETV in the treatment of CHB with severe acute exacerbation. From 2008 to 2013, 189 consecutive treatment-naive CHB patients receiving TDF (n= 41) or ETV (n= 148) for severe acute exacerbation were enrolled. The primary endpoint was overall mortality or receipt of liver transplantation by week 24. The baseline characteristics were comparable between these two groups. By week 24, 8 (19% [95% confidence interval {CI}, 7% to 32%]) patients in the TDF group and 26 (18% [95% CI, 11 to 24%]) patients in the ETV group died (n= 30) or received liver transplantation (n= 4) (P= 0.749). The two groups of patients developed similar rates of liver-related complications and achieved comparable biochemical and virological responses at week 24. Cox regression analysis showed that baseline viral DNA level (P= 0.002), hypertension (P= 0.002), model for end-stage liver disease (MELD) score (P= 0.01), platelet count (P= 0.005), early presence (within 4 weeks) of ascites (P= 0.005), hepatic encephalopathy (P= 0.002), and hepatorenal syndrome (P< 0.001) were independent factors for mortality or liver transplantation. Among the patients who survived by week 24, there was no difference between the two groups in the percentage of patients who had a serum creatinine increase of ≥0.5 mg/dl from baseline (6.7% [95% CI, 0% to 16%] versus 2.0% [95% CI, 0% to 4.8%] in the TDF and ETV groups, respectively;P= 0.231), whereas a significant reduction in the estimated glomerular filtration rate (eGFR) was found in the two groups (P= 0.001 for both). In conclusion, TDF and ETV produce a similar treatment response and clinical outcome in patients with severe acute exacerbation of CHB.

1988 ◽  
Vol 155 (4) ◽  
pp. 363-371 ◽  
Author(s):  
ATSUSHI KANNO ◽  
HIROSHI SUZUKI ◽  
YUTAKA MIYAZAKI ◽  
SCHUICHI SATO ◽  
MASAO OTSUKI ◽  
...  

2018 ◽  
Vol 50 (2) ◽  
pp. 163-167 ◽  
Author(s):  
Jung Gil Park ◽  
Yu Rim Lee ◽  
Soo Young Park ◽  
Heon Ju Lee ◽  
Won Young Tak ◽  
...  

2011 ◽  
Vol 54 (2) ◽  
pp. 236-242 ◽  
Author(s):  
Vincent Wai-Sun Wong ◽  
Grace Lai-Hung Wong ◽  
Karen Kar-Lum Yiu ◽  
Angel Mei-Ling Chim ◽  
Shirley Ho-Ting Chu ◽  
...  

2019 ◽  
Vol 64 (9) ◽  
pp. 2563-2569
Author(s):  
Yi-Hsing Chen ◽  
Sheng-Nan Lu ◽  
Jing-Hung Wang ◽  
Chao-Hung Hung ◽  
Tsung-Hui Hu ◽  
...  

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