Amphotericin B Induction with Voriconazole Consolidation as Salvage Therapy for FKS-Associated Echinocandin Resistance in Candida glabrata Septic Arthritis and Osteomyelitis

ABSTRACT We report the case of a 61-year-old female with Crohn’s disease dependent on total parenteral nutrition who developed a central venous catheter bloodstream infection and septic arthritis, complicated further by osteomyelitis and persistent Candida glabrata fungemia. Fluconazole treatment led to persistent infection, and micafungin therapy failed with development of FKS-associated resistance. Infection responded after initiation of amphotericin B plus voriconazole. Echinocandin resistance is increasingly recognized, suggesting a role for alternative antifungal therapies.

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Longitudinal assessment of patients knowledge and recognition of central venous catheter complications in home parenteral nutrition.

Clinical Nutrition ESPEN ◽

10.1016/j.clnesp.2015.03.017 ◽

2015 ◽

Vol 10 (5) ◽

pp. e183

Author(s):

M. Small ◽

S.M. Gabe

Keyword(s):

Central Venous Catheter ◽

Parenteral Nutrition ◽

Venous Catheter ◽

Home Parenteral Nutrition ◽

Longitudinal Assessment ◽

Central Venous ◽

Catheter Complications ◽

Central Venous Catheter Complications

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Intraluminal Antibiotic Treatment of Central Venous Catheter Infections in Patients Receiving Parenteral Nutrition at Home

Clinical Infectious Diseases ◽

10.1093/clind/24.4.743b ◽

1997 ◽

Vol 24 (4) ◽

pp. 743-744 ◽

Cited By ~ 12

Author(s):

J.-L. Benoit ◽

G. Carandang ◽

M. Sitrin ◽

P. Arnow

Keyword(s):

Central Venous Catheter ◽

Parenteral Nutrition ◽

Antibiotic Treatment ◽

Venous Catheter ◽

Central Venous ◽

Catheter Infections ◽

At Home

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Pericardial parenteral nutrition infusion following acute angulation of a neonatal polyurethane central venous catheter tip

Clinical Nutrition ◽

10.1016/s0261-5614(97)80039-8 ◽

1997 ◽

Vol 16 (5) ◽

pp. 263-264 ◽

Cited By ~ 2

Author(s):

A. Cade ◽

J.W.L. Puntis

Keyword(s):

Central Venous Catheter ◽

Parenteral Nutrition ◽

Venous Catheter ◽

Central Venous ◽

Catheter Tip

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CE Article: Central Venous Catheter Infection in Canadian Home Parenteral Nutrition Patients: A 5-Year Multicenter Retrospective Study

Journal of the Association for Vascular Access ◽

10.2309/j.java.2020.001.006 ◽

2020 ◽

Vol 25 (1) ◽

pp. 16-26

Author(s):

Olivia Saqui ◽

G. Fernandes ◽

J. Allard

Keyword(s):

Health Care ◽

Retrospective Study ◽

Patient Education ◽

Central Venous Catheter ◽

Parenteral Nutrition ◽

Venous Catheter ◽

Infection Rates ◽

Central Venous ◽

Central Venous Catheter Infection ◽

Significant Health

Highlights A lower CVC infection rate suggests an improvement in practice and education. CVC infection remains a complication that often requires significant health care resources. Use of tunneled CVC and patient education on catheter care reduces CVC infection rates.

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Complications of nutritional support

Emergencies in Gastroenterology and Hepatology ◽

10.1093/med/9780199231362.003.0011 ◽

2013 ◽

pp. 171-180

Author(s):

Daniel Marks ◽

Marcus Harbord

Keyword(s):

Central Venous Catheter ◽

Enteral Nutrition ◽

Parenteral Nutrition ◽

Right Atrium ◽

Nutritional Support ◽

Venous Catheter ◽

Central Venous ◽

Catheter Tip ◽

Central Catheters

Venous catheter-related problems Other complications of parenteral nutrition Problems with enteral tubes Re-feeding syndrome ● Above all else, ‘if the gut works, use it’. Only consider IV feeding if patients are likely to be without enteral nutrition for 〉5d. ● Central venous catheter feeding (i.e. catheter tip in SVC, IVC, or right atrium) preferred to avoid thrombophlebitis from hyperosmolar feeds. Well-managed central catheters can be left ...

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