Tuberculosis Arthritis Genu Sinistra with Drug-Induced Liver Injury, COVID 19 Confirmed

Background. Tuberculosis is still a significant health problem, especially in developing countries. Although pulmonary tuberculosis is the most common form of the disease, extrapulmonary tuberculosis also contributes significantly to morbidity and mortality. 10-15% of extrapulmonary cases are due to tuberculous arthritis. The following is a case report of a 36-year-old woman with a diagnosis of genu Sinistra tuberculosis arthritis and drug-induced hepatotoxic injury due to OAT. Case presentation. A woman, 36 years old, Muslim, addresses Banyuasin. The patient is a housewife, treated at Dr. Moh Hoesin General Hospital since October 11, 2021. The main complaint in the form of pain in the left knee has been getting worse since 1 week before being admitted to the hospital. 4 months before admission the hospital, the patient complained of left knee pain, the pain felt like being stabbed, coming and going, especially when walking. In this patient, there was a complaint of nausea that was felt in the pit of the stomach. The results of laboratory examinations showed an increase in the transaminase enzyme and hyperuricemia, so it was suspected that the patient had DILI due to OAT drugs. Hepatocyte death in DILI can occur through two processes, namely processes mediated by apoptosis or necrosis. In apoptosis, cell shrinkage and fragmentation occur into small pieces with the cell membrane intact. These fragments are cleared by phagocytosis and generally do not stimulate the host immune response. Conclusion. A patient diagnosed with arthritis tuberculosis genu Sinistra with Drug-Induced Liver Injury and Confirmed COVID 19.

Politics is making us sick: The negative impact of political engagement on public health during the Trump administration

Objectives To quantify the effect of politics on the physical, psychological, and social health of American adults during the four-year span of the Trump administration. Methods A previously validated politics and health scale was used to compare health markers in nationally representative surveys administered to separate samples in March 2017 (N = 800) and October 2020 (N = 700). Participants in the 2020 survey were re-sampled approximately two weeks after the 2020 election and health markers were compared to their pre-election baselines. Results Large numbers of Americans reported politics takes a significant toll on a range of health markers—everything from stress, loss of sleep, or suicidal thoughts to an inability to stop thinking about politics and making intemperate social media posts. The proportion of Americans reporting these effects stayed stable or slightly increased between the spring of 2017 and the fall of 2020 prior to the presidential election. Deterioration in measures of physical health became detectably worse in the wake of the 2020 election. Those who were young, politically interested, politically engaged, or on the political left were more likely to report negative effects. Conclusions Politics is a pervasive and largely unavoidable source of chronic stress that exacted significant health costs for large numbers of American adults between 2017 and 2020. The 2020 election did little to alleviate those effects and quite likely exacerbated them.

Quantifying Karenia brevis bloom severity and respiratory irritation impact along the shoreline of Southwest Florida

Nearly all annual blooms of the toxic dinoflagellate Karenia brevis (K. brevis) pose a serious threat to coastal Southwest Florida. These blooms discolor water, kill fish and marine mammals, contaminate shellfish, cause mild to severe respiratory irritation, and discourage tourism and recreational activities, leading to significant health and economic impacts in affected communities. Despite these issues, we still lack standard measures suitable for assessing bloom severity or for evaluating the efficacy of modeling efforts simulating bloom initiation and intensity. In this study, historical cell count observations along the southwest Florida shoreline from 1953 to 2019 were used to develop monthly and annual bloom severity indices (BSI). Similarly, respiratory irritation observations routinely reported in Sarasota and Manatee Counties from 2006 to 2019 were used to construct a respiratory irritation index (RI). Both BSI and RI consider spatial extent and temporal evolution of the bloom, and can be updated routinely and used as objective criteria to aid future socioeconomic and scientific studies of K. brevis. These indices can also be used to help managers and decision makers both evaluate the risks along the coast during events and design systems to better respond to and mitigate bloom impacts. Before 1995, sampling was done largely in response to reports of discolored water, fish kills, or respiratory irritation. During this timeframe, lack of sampling during the fall, when blooms typically occur, generally coincided with periods of more frequent-than-usual offshore winds. Consequently, some blooms may have been undetected or under-sampled. As a result, the BSIs before 1995 were likely underestimated and cannot be viewed as accurately as those after 1995. Anomalies in the frequency of onshore wind can also largely account for the discrepancies between BSI and RI during the period from 2006 to 2019. These findings highlighted the importance of onshore wind anomalies when predicting respiratory irritation impacts along beaches.

Protein-Protein Interactions (PPI) via Deep Neural Network (DNN)

Entering the 21st century, computer science and biological research have entered a stage of rapid development. With the rapid inflow of capital into the field of significant health research, a large number of scholars and investors have begun to focus on the impact of neural network science on biometrics, especially the study of biological interactions. With the rapid development of computer technology, scientists improve or perfect traditional experimental methods. This chapter aims to prove the reliability of the methodology and computing algorithms developed by Satyajit Mahapatra and Ivek Raj Gupta's project team. In this chapter, three datasets take the responsibility to testify the computing algorithms, and they are S. cerevisiae, H. pylori, and Human-B. Anthracis. Among these three sets of data, the S. cerevisiae is the core subset. The result shows 87%, 87.5%, and 89% accuracy and 87%, 86%, and 87% precision for these three data sets, respectively.

Diagnosis and management of COPD in primary care

Chronic obstructive pulmonary disease is a significant health problem. However, a large proportion of cases remain undiagnosed. Early diagnosis of chronic obstructive pulmonary disease leads to earlier treatment initiation, and in consequence, to improvement of patients quality of life. The gold standard for chronic obstructive pulmonary disease diagnosis is spirometry and the presence of irreversible obstruction after a bronchodilator. One of the most important interventions in the treatment of chronic obstructive pulmonary disease is anti-smoking education. The main group of drugs used in chronic obstructive pulmonary disease treatment are the long-acting bronchodilators.

Relationship between Wildfire Smoke and Children’s Respiratory Health in the Metropolitan Cities of Central-Chile

Wildfire causes multiple problems for people living in cities. One of them is the deterioration of air quality as a result of wildfire smoke. This smoke can consequently have effects on human health. The present study aims to characterize the relationship between the occurrence of wildfires in central Chile and the effects on children’s respiratory health. Public databases provided the number of emergency care visits, wildfires, and concentration of air pollutants, demographics and meteorological variables for the regions of Santiago and Valparaiso from 2010 to 2013. Time series analysis was used monthly on health care visits to determine the relative health risk in children when in the presence of additional wildfires. Significant health risks were observed in Santiago for children younger than 1-year-old of bronchitis (RR 1.007, CI 95% 1.007–1.008; chronic lower respiratory diseases (RR 1.012, CI 95% 1.012–1.013); and pneumonia (RR 1.026 CI 95% 1.026–1.027) and in children aged one to four years old (RR 1.016 CI 95% 1.015–1.016). A dose-response relationship was also observed for pneumonia, showing that it affects younger children particularly when there is an increase in the number of wildfires. In the Region of Valparaíso, wildfires did not significantly change the risk of respiratory illness, this could be due to favorable ventilation. Currently, Santiago has an urgent need for monitoring and the evaluation of the damage to children’s respiratory health, along with the development of comprehensive prevention strategies.

Change of Ba concentration by species and organ in several fruits grown in city centers

Heavy metals are elements that are very harmful to human and environmental health. Heavy metal concentration in the fruits grown in city centers can reach very high levels and consuming these fruits as food causes a direct intake of heavy metals, which these fruits contain, into a human body and can pose a significant health risk. All the compounds of barium (Ba), which is one of the most dangerous heavy metals, are toxic. Thus, determining the Ba concentration in plants, which are grown in areas with high pollution and consumed as food, is very important. In the present study, it was aimed to determine the change of Ba concentration by species and organ in several fruits grown in areas with high traffic density. Within the scope of this study, Ba concentrations in leaf, branch, bark, seed, and fruits of Prunus ceresifera, Tilia tomentosa, Prunus avium, and Prunus cerasus were compared. As a result, it was determined that the change of Ba concentrations by species and the change by organ were statistically significant in all organs and in all species, respectively. In general, the lowest values were found in Prunus cerasus or Prunus avium, whereas the highest values were observed in Tilia tomentosa. Considering the organs, the lowest values were found in seed and the highest ones in bark and branch.

Aflatoxin in feedstuffs and raw milk in Republic of North Macedonia, occurrence and assessment

The main objective of this research is to estimate the situation of occurance of aflatoxins in feedstuffs and aflatoxin M1 raw cow`s milk in Republic of North Macedonia. Detected average concentrations of total aflatoxins in the examined period 2014-2017 were below legal prescribed level. Within the official monitoring programme in the country, 1718 samples of raw cow's milk have been analyzed during 2017 and 2018. Comparison of the data showed that the number of examined samples with values for aflatoxin M1 above the allowed limits, according to the regulation is in 2018 (10 samples) and 2017 (5 samples). Additionally, the calculation of exposure assessment of the human population in North Macedonia demonstrated that the exposure to AFM1 of the adult population in N. Macedonia for 2017 is 0.0563 ng/kg bw/daily, and for 2018 is 0.0824 ng/kg bw/daily. The calculated hazard index (HI) In both years, was lower than one, which means that there are no significant health risks for the consumers. It is important to have continuously low levels of aflatoxins in animal feed and nutrition, especially that the climate changes create more favorable conditions for the development of moulds of Aspergillus.

Disorders caused by contaminated fish meat consumption: Literature review / Doenças causadas por consume de carne de peixe contaminada: Revisão de literatura

Between 2007 and 2017, Brazil registered 99,826 outbreaks of foodborne diseases and 0.84% of those were associated with fish meat intake. It is estimated that approximately 56 million infection cases occur worldwide due to raw or undercooked fish meat containing several disease-causing parasites. Hence, this study aimed to review the literature concerning diseases caused by ingestion of contaminated fish meat. Reviews, case reports and epidemiologic studies were searched in Portuguese, Spanish and English in the databases LILACS, Pubmed, Science Direct, SciElo and Scholar Google using as keywords: transmissive diseases, contaminated fish and human infections were used to retrieve papers from 2014 to 2020. Nine papers, including seven reviews, one case report and one case-control study fulfilled inclusion criteria and presented several consequences of contaminated raw or undercooked fish meat ingestion, which ranged from nemathode, bacterial and toxin diseases that may cause gastrointestinal problems to allergic reactions, lung infection, endemic acute myalgia, bacteremia, meningitis and death. Growing fish meat intake in several dishes presents significant health risk due to the pathogenic potential of toxins and parasites that remain when food is consumed raw or undercooked. Tighter sanitary surveillance, population health education, training and sensitization of health professionals in recognizing and notifying cases might contribute to minimize risk.

Mineral Composition of Dietary Supplements-Analytical and Chemometric Approach

There is a lack of data on the actual composition and effectiveness of beetroot-based dietary supplements. The research aimed to determine the profile of 22 elements (Na, K, Ca, Mg, P, Fe, As, Se, Zn, Cu, Ag, Co, Ni, Mo, Al, Mn, Sr, Cr, Ba, Li, Pb, Cd) in beetroot and its supplements by the microwave plasma atomic emission spectrometry (MP-AES) method. The analytical procedure was optimised and validated. The composition of both groups was compared, assessing compliance with the recommended daily doses for the chosen elements, and the health risk was estimated. Furthermore, chemometric analysis was applied. Beetroots constituted a significant source of elements, especially K, Na, Mg, Ca, P, in contrast to supplements which contained their negligible amounts except from iron-enriched products which provided notable amounts of Fe (38.3–88% of the Recommended Dietary Allowance for an adult male from 19 to 75 years old). Some products were significantly contaminated with toxic elements (As, Cd). Factor and cluster analyses were helpful in the differentiation of beetroot and its supplements in view of their type (vegetable, supplement, iron-enriched supplement), origin, type of cultivation (conventional, organic), and form (capsule, tablet) based on their mineral composition. The obtained results indicate the need for more stringent control of supplements, as they may pose a significant health risk to consumers.