Successful treatment of disseminated disease due to highly resistant Aspergillus calidoustus with a novel antifungal therapy

Invasive aspergillosis is the most common invasive mold infection following a hematopoietic cell transplant. Widespread use of antifungal prophylaxis has led to increasing incidence of cryptic Aspergillus species. Aspergillus calidoustus is one of those emerging species and is notorious for multidrug resistance to antifungals. Here we report a case of disseminated A. calidoustus infection in a hematopoietic stem cell transplant recipient, who was successfully treated with combination therapy that included a novel antifungal.