Genotypic and phenotypic changes during culture of a multinucleoside-resistant human immunodeficiency virus type 1 strain in the presence and absence of additional reverse transcriptase inhibitors.
1996 ◽
Vol 40
(12)
◽
pp. 2887-2890
◽
Keyword(s):
The observation that human immunodeficiency virus type 1 (HIV-1) mutations conferring resistance to one reverse transcriptase (RT) inhibitor may suppress resistance to other RT inhibitors provides a rationale for treating HIV-1 with certain RT inhibitor combinations. We examined phenotypic and genotypic changes during culture of a multinucleoside (zidovudine, didanosine, zalcitibine, and stavudine)-resistant HIV-1 strain with and without additional RT inhibitors (nevirapine and lamivudine). The development of nevirapine or lamivudine resistance by the multinucleoside-resistant strain was not accompanied by a reduction in zidovudine or didanosine resistance.
2006 ◽
Vol 50
(8)
◽
pp. 2772-2781
◽
2010 ◽
Vol 10
(1)
◽
pp. 62-72
◽
1999 ◽
Vol 73
(4)
◽
pp. 3455-3459
◽
1993 ◽
Vol 18
(11)
◽
pp. 1043
◽
1996 ◽
Vol 16
(2)
◽
pp. 125-157
◽
2008 ◽
Vol 53
(3)
◽
pp. 1194-1203
◽
2001 ◽
Vol 45
(6)
◽
pp. 1836-1842
◽
2005 ◽
Vol 49
(7)
◽
pp. 2648-2656
◽