scholarly journals Anti-influenza virus cytotoxic T lymphocytes recognize the three viral polymerases and a nonstructural protein: responsiveness to individual viral antigens is major histocompatibility complex controlled.

1987 ◽  
Vol 61 (4) ◽  
pp. 1098-1102 ◽  
Author(s):  
J R Bennink ◽  
J W Yewdell ◽  
G L Smith ◽  
B Moss
Keyword(s):  
Influenza Virus ◽  
Major Histocompatibility Complex ◽  
T Lymphocytes ◽  
Cytotoxic T Lymphocytes ◽  
Nonstructural Protein ◽  
Major Histocompatibility ◽  
Viral Antigens ◽  
Histocompatibility Complex

scholarly journals The control of specificity of cytotoxic T lymphocytes by the major histocompatibility complex (AG-B) in rats and identification of a new alloantigen system showing no AG-B restriction.

1977 ◽  
Vol 146 (6) ◽  
pp. 1773-1790 ◽  
Author(s):  
A Marshak ◽  
P C Doherty ◽  
D B Wilson
Keyword(s):  
Major Histocompatibility Complex ◽  
T Lymphocytes ◽  
Cytotoxic T Lymphocytes ◽  
Third Party ◽  
Cytotoxic T Cell ◽  
Target Cells ◽  
Cytotoxic Lymphocytes ◽  
Major Histocompatibility ◽  
Histocompatibility Complex ◽  
Ct Antigens

The regulatory influence of the rat major histocompatibility complex (MHC) (Ag-B complex) on the specificity of cytotoxic T lymphocytes was investigated. It was shown that the effector cells were specific for the original Ag-B phenotype in rat systems in which the responder and stimulator cell populations were unquestionably MHC identical but expressed different minor alloantigens of viral antigens. However, combined in vivo immunization and restimulation in culture of lymphocytes from rat strains previously thought to be MHC compatible resulted in the generation of cytotoxic T lymphocytes which effectively lyse not only target cells from the specific stimulating strains but also, to varying degrees, target cells from third party strains regardless of their Ag-B haplotypes. Genetic analysis indicates that expression of these cytotoxic T-cell-defined ("CT") antigens, found on both T and B lymphocytes, detectable thus far only with cytotoxic lymphocytes, is controlled by a single locus which segregates in backcross populations with the rat MHC. Discrepancies between the nature of CT antigens of the rat Ag-B and I-region specificities of the mouse H-2 are discussed.

Major Histocompatibility Complex–Restricted Lysis of Neuroblastoma Cells by Autologous Cytotoxic T Lymphocytes

2001 ◽  
Vol 24 (4) ◽  
pp. 305-311 ◽  
Author(s):  
Asis K. Sarkar ◽  
Susan M. Burlingame ◽  
Ying Q. Zang ◽  
Vicky Dulai ◽  
M. John Hicks ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
T Lymphocytes ◽  
Cytotoxic T Lymphocytes ◽  
Neuroblastoma Cells ◽  
Major Histocompatibility ◽  
Histocompatibility Complex
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