scholarly journals An amino-terminal fragment of the Friend murine leukemia virus envelope glycoprotein binds the ecotropic receptor.

1991 ◽  
Vol 65 (8) ◽  
pp. 4026-4032 ◽  
Author(s):  
J M Heard ◽  
O Danos
Keyword(s):  
Envelope Glycoprotein ◽  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Virus Envelope ◽  
Amino Terminal ◽  
Terminal Fragment ◽  
Amino Terminal Fragment ◽  
Murine Leukemia

Molecular domains involved in oligomerization of the friend murine leukemia virus envelope glycoprotein

Virology ◽  
1991 ◽  
Vol 185 (2) ◽  
pp. 710-720 ◽  
Author(s):  
Simon P. Tucker ◽  
Ranga V. Srinivas ◽  
Richard W. Compans
Keyword(s):  
Envelope Glycoprotein ◽  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Virus Envelope ◽  
Murine Leukemia

scholarly journals Characterization of Retroviral and Lentiviral Vectors Pseudotyped with Xenotropic Murine Leukemia Virus-Related Virus Envelope Glycoprotein

2010 ◽  
Vol 21 (12) ◽  
pp. 1665-1673 ◽  
Author(s):  
Toshie Sakuma ◽  
Suk See De Ravin ◽  
Jason M. Tonne ◽  
Tayaramma Thatava ◽  
Seiga Ohmine ◽  
...  
Keyword(s):  
Envelope Glycoprotein ◽  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Lentiviral Vectors ◽  
Virus Envelope ◽  
Xenotropic Murine Leukemia ◽  
Related Virus ◽  
Murine Leukemia

scholarly journals The tyrosine-based YXXØ targeting motif of murine leukemia virus envelope glycoprotein affects pathogenesis

Virology ◽  
2004 ◽  
Vol 324 (1) ◽  
pp. 173-183 ◽  
Author(s):  
Carole Danis ◽  
Julie Deschambeault ◽  
Sonia Do Carmo ◽  
Éric A Cohen ◽  
Éric Rassart ◽  
...  
Keyword(s):  
Envelope Glycoprotein ◽  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Virus Envelope ◽  
Murine Leukemia

scholarly journals Sequential activation of the three protomers in the Moloney murine leukemia virus Env

2017 ◽  
Vol 114 (10) ◽  
pp. 2723-2728 ◽  
Author(s):  
Mathilda Sjöberg ◽  
Robin Löving ◽  
Birgitta Lindqvist ◽  
Henrik Garoff
Keyword(s):  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Moloney Murine Leukemia Virus ◽  
Virus Envelope ◽  
Sequential Activation ◽  
Virus Envelope Protein ◽  
Membrane Fusion Proteins ◽  
Viral Membrane Fusion ◽  
Murine Leukemia

Viral membrane fusion proteins of class I are trimers in which the protomeric unit is a complex of a surface subunit (SU) and a fusion active transmembrane subunit (TM). Here we have studied how the protomeric units of Moloney murine leukemia virus envelope protein (Env) are activated in relation to each other, sequentially or simultaneously. We followed the isomerization of the SU-TM disulfide and subsequent SU release from Env with biochemical methods and found that this early activation step occurred sequentially in the three protomers, generating two asymmetric oligomer intermediates according to the scheme (SU-TM)3→ (SU-TM)2TM → (SU-TM)TM2→ TM3. This was the case both when activation was triggered in vitro by depleting stabilizing Ca2+from solubilized Env and when viral Env was receptor triggered on rat XC cells. In the latter case, the activation reaction was too fast for direct observation of the intermediates, but they could be caught by alkylation of the isomerization active thiol.

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