scholarly journals In vitro analysis of a primary, major histocompatibility complex (MHC)-restricted, cytotoxic T-lymphocyte response to avian leukosis virus (ALV), using target cells expressing MHC class I cDNA inserted into a recombinant ALV vector.

1995 ◽  
Vol 69 (10) ◽  
pp. 6439-6444 ◽  
Author(s):  
E L Thacker ◽  
J E Fulton ◽  
H D Hunt
Keyword(s):  
Mhc Class I ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Target Cells ◽  
Lymphocyte Response ◽  
Histocompatibility Complex ◽  
Vitro Analysis ◽  
Cytotoxic T Lymphocyte Response ◽  
In Vitro Analysis

scholarly journals BAG-6 is essential for selective elimination of defective proteasomal substrates

2010 ◽  
Vol 190 (4) ◽  
pp. 637-650 ◽  
Author(s):  
Ryosuke Minami ◽  
Atsuko Hayakawa ◽  
Hiroki Kagawa ◽  
Yuko Yanagi ◽  
Hideyoshi Yokosawa ◽  
...  
Keyword(s):  
Mhc Class I ◽  
Mammalian Cells ◽  
Human Major Histocompatibility Complex ◽  
Histocompatibility Complex ◽  
Selective Elimination ◽  
Nascent Chain ◽  
Vitro Analysis ◽  
In Vitro Analysis

BAG-6/Scythe/BAT3 is a ubiquitin-like protein that was originally reported to be the product of a novel gene located within the human major histocompatibility complex, although the mechanisms of its function remain largely obscure. Here, we demonstrate the involvement of BAG-6 in the degradation of a CL1 model defective protein substrate in mammalian cells. We show that BAG-6 is essential for not only model substrate degradation but also the ubiquitin-mediated metabolism of newly synthesized defective polypeptides. Furthermore, our in vivo and in vitro analysis shows that BAG-6 interacts physically with puromycin-labeled nascent chain polypeptides and regulates their proteasome-mediated degradation. Finally, we show that knockdown of BAG-6 results in the suppressed presentation of MHC class I on the cell surface, a procedure known to be affected by the efficiency of metabolism of defective ribosomal products. Therefore, we propose that BAG-6 is necessary for ubiquitin-mediated degradation of newly synthesized defective polypeptides.

Neurotransmitter suppression of the in vitro generation of a cytotoxic T lymphocyte response against the syngeneic MOPC-315 plasmacytoma

1995 ◽  
Vol 40 (2) ◽  
pp. 79-87 ◽  
Author(s):  
Joan M. Cook-Mills ◽  
Margalit B. Mokyr ◽  
Rhonna L. Cohen ◽  
Robert L. Perlman ◽  
Donald A. Chambers
Keyword(s):  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Lymphocyte Response ◽  
Cytotoxic T Lymphocyte Response

Oligopeptide Induction of a Cytotoxic T Lymphocyte Response to HER-2/Neu Proto-oncogene in Vitro

1994 ◽  
Vol 157 (2) ◽  
pp. 415-427 ◽  
Author(s):  
Bryan Fisk ◽  
Brad Chesak ◽  
Marilyn S. Pollack ◽  
J.Taylor Wharton ◽  
Constantin G. Ioannides
Keyword(s):  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Lymphocyte Response ◽  
Her 2 ◽  
Cytotoxic T Lymphocyte Response

Neurotransmitter suppression of the in vitro generation of a cytotoxic T lymphocyte response against the syngeneic MOPC-315 plasmacytoma

1995 ◽  
Vol 40 (2) ◽  
pp. 79-87
Author(s):  
Joan M. Cook-Mills ◽  
Margalit B. Mokyr ◽  
Rhonna L. Cohen ◽  
Robert L. Perlman ◽  
Donald A. Chambers
Keyword(s):  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Lymphocyte Response ◽  
Cytotoxic T Lymphocyte Response

HLAMatchmaker Algorithm is not a Suitable Tool to Predict the Alloreactive Cytotoxic T-Lymphocyte Response in vitro

2004 ◽  
Vol 78 (1) ◽  
pp. 165-167 ◽  
Author(s):  
Marlies K. A. Dankers ◽  
Martin B. A. Heemskerk ◽  
Rene J. Duquesnoy ◽  
Ilias I. N. Doxiadis ◽  
Machteld Oudshoorn ◽  
...  
Keyword(s):  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Lymphocyte Response ◽  
Suitable Tool ◽  
Cytotoxic T Lymphocyte Response
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