Elaboration of immune stimulating lipid-saponin subunit antigen carrier based on glycolipid monogalactosyldiacylglycerol from sea macrophytes and triterpene glycosides from Cucumaria japonica

The radioprotective activity has been studied of a new immunomodulatory lead material, Cumaside, which is a complex of monosulfated triterpene glycosides from the edible sea cucumber Cucumaria japonica and cholesterol. Female CD-1 strain mice administered with prophylactic doses of Cumaside were irradiated using a Gamma-therapeutic device with a 60Co source (exposure dose 6.5 Gy, dose rate 1.14 Gy /min) and the average life span of the mice was determined. The animals administrated with Cumaside and irradiated were killed by pervisceral dislocation on days 4 and 9. Peripheral blood cell composition indexes, blood forming function and cell number in blood-forming organs and the number of pluripotent blood-forming stem cells were determined using standard procedures and the results compared with those of non-treated irradiated mice. The survivability percentage and average life span of the irradiated mice that were not treated with Cumaside were decreased in comparison with the Cumaside-treated groups. Especially, the leukocyte and neutrophil numbers in the blood (bone marrow from hip), and the weight and cell number of lymphoid organs were higher in the Cumaside-treated groups compared with the non-treated irradiated mice. It was concluded that at low prophylactic doses Cumaside possesses moderate radioprotective properties.

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Influence of Triterpene Glycosides of the Holothurian Cucumaria japonica on Root Growth in Cucumis sativus L. Seedlings

Biology Bulletin ◽

10.1023/b:bibu.0000036947.25869.a8 ◽

2004 ◽

Vol 31 (4) ◽

pp. 416-422

Author(s):

M. M. Anisimov ◽

V. V. Logachev ◽

A. S. Sil'chenko ◽

S. A. Avilov

Keyword(s):

Root Growth ◽

Cucumis Sativus ◽

Triterpene Glycosides ◽

Cucumis Sativus L ◽

Cucumaria Japonica

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The use of tritium-labeled triterpene glycosides from the holothurian Cucumaria japonica in pharmacokinetic studies

Doklady Biological Sciences ◽

10.1134/s0012496608050207 ◽

2008 ◽

Vol 422 (1) ◽

pp. 345-347 ◽

Cited By ~ 9

Author(s):

D. L. Aminin ◽

V. P. Shevchenko ◽

I. Yu. Nagaev ◽

R. V. Gladkikh ◽

I. I. Kapustina ◽

...

Keyword(s):

Triterpene Glycosides ◽

Pharmacokinetic Studies ◽

Cucumaria Japonica

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Structures of four new triterpene glycosides from the holothurian Cucumaria japonica

Chemistry of Natural Compounds ◽

10.1007/bf00630079 ◽

1990 ◽

Vol 26 (6) ◽

pp. 670-675 ◽

Cited By ~ 10

Author(s):

S. A. Avilov ◽

V. A. Stonik ◽

A. I. Kalinovskii

Keyword(s):

Triterpene Glycosides ◽

Cucumaria Japonica

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Immunogenic antigen-carrier protein conjugate for use in a vaccine against malaria

Molecular Immunology ◽

10.1016/0161-5890(87)90155-6 ◽

1987 ◽

Vol 24 (3) ◽

pp. i

Keyword(s):

Carrier Protein ◽

Protein Conjugate ◽

Antigen Carrier

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Triterpene glycosides ofSalsola micranthera. II. The strucutre of salsoloside E

Chemistry of Natural Compounds ◽

10.1007/bf00574792 ◽

1984 ◽

Vol 20 (1) ◽

pp. 60-64

Author(s):

Ch. Annaev ◽

M. Isamukhamedova ◽

N. K. Abubakirov

Keyword(s):

Triterpene Glycosides

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Two new oleanane triterpene glycosides from Gymnema inodorum

Journal of Chemical Research ◽

10.3184/030823408x375115 ◽

2008 ◽

Vol 2008 (11) ◽

pp. 655-657 ◽

Cited By ~ 8

Author(s):

Dingyong Wang ◽

Guocheng Li ◽

Yujing Feng ◽

Suying Xu

Keyword(s):

Triterpene Glycosides ◽

Dioic Acid

Two new oleanane triterpene glycosides were isolated from the n-BuOH extract of Gymnema inodorum. On the basis of spectroscopic evidences, their structures were elucidated as 2α, 3β-dihydroxy-olean-12-ene-23, 28-dioic acid-3-O-β-D-glucopyrano-side and 2α, 3β, 15β-trihydroxy-olean-12-ene-23, 28-dioic acid-3-O-β-D-gluco-pyranoside.

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