Features of the immune proteasome expression in ascite Zajdela hepatoma after implantation into Brattleboro rats with the hereditary defect of arginine-vasopressin synthesis

2014 ◽  
Vol 40 (6) ◽  
pp. 658-665
Author(s):  
V. I. Mel’nikova ◽  
I. I. Khegai ◽  
N. A. Popova ◽  
N. V. Lifantseva ◽  
L. N. Ivanova ◽  
...  
Keyword(s):  
Arginine Vasopressin ◽  
Brattleboro Rats ◽  
Zajdela Hepatoma ◽  
Hereditary Defect ◽  
Vasopressin Synthesis

Pattern of MHC class I and immune proteasome expression in Walker 256 tumor during growth and regression in Brattleboro rats with the hereditary defect of arginine-vasopressin synthesis

2011 ◽  
Vol 271 (2) ◽  
pp. 385-391 ◽  
Author(s):  
Liudmila A. Zakharova ◽  
Igor I. Khegai ◽  
Natalia P. Sharova ◽  
Victoria I. Melnikova ◽  
Yaroslava D. Karpova ◽  
...  
Keyword(s):  
Mhc Class I ◽  
Arginine Vasopressin ◽  
Class I ◽  
Brattleboro Rats ◽  
Hereditary Defect ◽  
Walker 256 ◽  
Vasopressin Synthesis ◽  
Walker 256 Tumor

Antidiuretic antagonism and agonism of 1-deamino-pentamethylene-2-d-phenylalanine-4-isoleucine-arginine vasopressin in rats with diabetes insipidus

1987 ◽  
Vol 112 (3) ◽  
pp. 439-442 ◽  
Author(s):  
H. Vilhardt ◽  
S. Lundin
Keyword(s):  
Diabetes Insipidus ◽  
Arginine Vasopressin ◽  
Test Model ◽  
Brattleboro Rats ◽  
Experimental Conditions ◽  
Vasopressin Antagonist ◽  
Agonist Action

ABSTRACT Using implanted minipumps it was shown over a period of 7 days that the vasopressin antagonist, 1-deamino-pentamethylene-2-d-Phe-4-Ile-arginine vasopressin, caused increased diuresis in normal rats and reversed vasopressin- or oxytocin-induced antidiuresis in Brattleboro rats. When the antagonist was infused alone in Brattleboro rats it induced a marked antidiuretic response, indicating that the analogue also possessed agonistic properties. The agonist action could not be demonstrated in anaesthetized, hydrated normal rats. In these animals the analogue behaved as a pure antagonist. It is concluded that analogues which behave as antagonists in one test model may display agonistic properties under different experimental conditions. J. Endocr. (1987) 112, 439–442

Contribution of vasopressin to the maintenance of blood pressure during dehydration

1983 ◽  
Vol 245 (5) ◽  
pp. F615-F621 ◽  
Author(s):  
R. L. Woods ◽  
C. I. Johnston
Keyword(s):  
Blood Pressure ◽  
Body Weight ◽  
Systolic Blood Pressure ◽  
Arginine Vasopressin ◽  
Cardiovascular Response ◽  
Urine Volume ◽  
Brattleboro Rats ◽  
Continuous Administration ◽  
Plasma Vasopressin ◽  
Long Evans

Normal Long-Evans rats, when dehydrated for up to 72 h, have a progressive rise in plasma vasopressin that is associated with a fall in body weight and urine volume, a rise in plasma and urine osmolality, and the maintenance of normal systolic blood pressure. In contrast, Brattleboro diabetes insipidus rats, genetically deficient in vasopressin, when dehydrated to achieve an equivalent body weight loss, have a significant 15 mmHg fall in systolic blood pressure. Even when fluid balance is corrected in the Brattleboro rats by the continuous administration of 1-desamino-8-D-arginine vasopressin, a synthetic vasopressin analogue with potent antidiuretic properties but minimal pressor activity, blood pressure still falls when the animals are dehydrated. In contrast, Brattleboro rats infused with exogenous arginine vasopressin to produce a plasma vasopressin level of 18.9 +/- 3.5 pg X ml-1 are able to maintain normal blood pressure during 48 h of dehydration. This level of vasopressin is comparable to the level found endogenously in dehydrated Long-Evans rats and is nonpressor in normal rats. These results suggest that both the antidiuretic and vasoconstrictor properties of vasopressin are important in the cardiovascular response to dehydration.

NaCl and Ca delivery at the bend of rat deep nephrons decreases during antidiuresis

1987 ◽  
Vol 252 (6) ◽  
pp. F1055-F1064 ◽  
Author(s):  
J. M. Elalouf ◽  
D. Chabane Sari ◽  
N. Roinel ◽  
C. de Rouffignac
Keyword(s):  
Parathyroid Hormone ◽  
Diabetes Insipidus ◽  
Arginine Vasopressin ◽  
Distal Tubule ◽  
Water Removal ◽  
Loop Of Henle ◽  
Brattleboro Rats ◽  
Previous Hypothesis

The effects of 1-desamino-8-D-arginine vasopressin (dDAVP) on superficial and juxtamedullary nephrons were investigated by micropuncture in diabetes insipidus (DI) Brattleboro rats chronically treated with the peptide. The rats, acutely deprived of endogenous calcitonin, parathyroid hormone (PTH), and glucagon [hormone-deprived (HD) rats], were examined either 4 days after cessation of dDAVP treatment (HDT, control diuretic rats) or when the treatment was continued until the micropuncture experiment, during which dDAVP was also given intravenously (HDT + dDAVP, experimental nondiuretic rats). In the presence of dDAVP, the reabsorption of Cl, Na, Mg, and Ca by the superficial loop of Henle was significantly increased, as previously observed in HD-untreated rats during acute infusion of dDAVP. The effects on the superficial distal tubule were also similar. The effects on K, however, were different both in the loop and in the distal tubule. At the bend of the juxtamedullary nephrons, the treatment alone (HDT rats) increased fractional delivery (FD%) of Na and Cl, whereas FD% of Mg, Ca, K, and P was unaltered. In HDT + dDAVP rats, FD% of H2O, Cl, Na, and Ca was significantly lower than in HDT rats, and FD% of K, Mg, and P did not differ significantly. In conclusion, in the presence of dDAVP, the FD% of H2O, Na, and Cl at the bend of the long-loop nephrons decreases, in accordance with our previous hypothesis that water removal along the rat descending limb increases outward NaCl diffusion along this segment.

scholarly journals Effects of acute kidney dysfunction on hypothalamic arginine vasopressin synthesis in transgenic rats

2019 ◽  
Vol 69 (3) ◽  
pp. 531-541 ◽  
Author(s):  
Hiromichi Ueno ◽  
Ryota Serino ◽  
Kenya Sanada ◽  
Yasuki Akiyama ◽  
Kentaro Tanaka ◽  
...  
Keyword(s):  
Arginine Vasopressin ◽  
Transgenic Rats ◽  
Kidney Dysfunction ◽  
Vasopressin Synthesis

4-Phenylalanine analogues of vasopressin: Synthesis, pharmacological and chiroptical properties

1986 ◽  
Vol 51 (7) ◽  
pp. 1532-1541 ◽  
Author(s):  
František Brtník ◽  
Tomislav Barth ◽  
Petr Maloň ◽  
Ivo Frič ◽  
Vija E. Kluša ◽  
...  
Keyword(s):  
Arginine Vasopressin ◽  
Pharmacological Properties ◽  
Cd Spectra ◽  
Chiroptical Properties ◽  
Lysine Vasopressin ◽  
Vasopressin Synthesis

Synthesis, some pharmacological properties and CD spectra of [4-phenylalanine, 8-arginine]vasopressin and [4-phenylalanine, 8-lysine]vasopressin are described.

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