Effects of acute kidney dysfunction on hypothalamic arginine vasopressin synthesis in transgenic rats

Synthesis, some pharmacological properties and CD spectra of [4-phenylalanine, 8-arginine]vasopressin and [4-phenylalanine, 8-lysine]vasopressin are described.

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Upregulation of arginine vasopressin synthesis in the rat hypothalamus after kainic acid-induced seizures

Brain Research ◽

10.1016/j.brainres.2011.09.030 ◽

2011 ◽

Vol 1424 ◽

pp. 1-8 ◽

Cited By ~ 13

Author(s):

Masaru Iwanaga ◽

Motoko Ohno ◽

Akiko Katoh ◽

Toyoaki Ohbuchi ◽

Toru Ishikura ◽

...

Keyword(s):

Kainic Acid ◽

Arginine Vasopressin ◽

Rat Hypothalamus ◽

Vasopressin Synthesis

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In vivoprocessing and release into the circulation of GFP fusion protein in arginine vasopressin enhanced GFP transgenic rats: response to osmotic stimulation

FEBS Journal ◽

10.1111/febs.13291 ◽

2015 ◽

Vol 282 (13) ◽

pp. 2488-2499 ◽

Cited By ~ 10

Author(s):

Keita Satoh ◽

Takumi Oti ◽

Akiko Katoh ◽

Yoichi Ueta ◽

John F. Morris ◽

...

Keyword(s):

Fusion Protein ◽

Arginine Vasopressin ◽

Transgenic Rats ◽

Gfp Fusion Protein ◽

Osmotic Stimulation

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Pattern of MHC class I and immune proteasome expression in Walker 256 tumor during growth and regression in Brattleboro rats with the hereditary defect of arginine-vasopressin synthesis

Cellular Immunology ◽

10.1016/j.cellimm.2011.08.005 ◽

2011 ◽

Vol 271 (2) ◽

pp. 385-391 ◽

Cited By ~ 8

Author(s):

Liudmila A. Zakharova ◽

Igor I. Khegai ◽

Natalia P. Sharova ◽

Victoria I. Melnikova ◽

Yaroslava D. Karpova ◽

...

Keyword(s):

Mhc Class I ◽

Arginine Vasopressin ◽

Class I ◽

Brattleboro Rats ◽

Hereditary Defect ◽

Walker 256 ◽

Vasopressin Synthesis ◽

Walker 256 Tumor

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Muscarinic M2 receptor promotes vasopressin synthesis in mice supraoptic nuclei

Journal of Endocrinology ◽

10.1530/joe-17-0630 ◽

2018 ◽

Vol 237 (2) ◽

pp. 207-216

Author(s):

Hiroshi Nagano ◽

Yuki Sobue ◽

Hayato Matsuyama ◽

Shoichiro Saito ◽

Hiroki Sakai ◽

...

Keyword(s):

Arginine Vasopressin ◽

Knockout Mice ◽

Receptor Expression ◽

Muscarinic Agonist ◽

Wild Type ◽

Vasopressin Release ◽

Paraventricular Nuclei ◽

Vasopressin Secretion ◽

Vasopressin Synthesis ◽

Supraoptic Nuclei

Muscarinic acetylcholine receptors have been suggested to be implicated in arginine–vasopressin secretion because intracerebroventricular muscarinic agonist administration induces arginine–vasopressin release into the circulation. Although which subtype is involved in the regulation of arginine–vasopressin secretion is unclear, M2 receptors have been reported to be highly expressed in the hypothalamus. In the present study, M2 receptor-knockout mice were used to elucidate whether M2 receptor regulates arginine–vasopressin synthesis in the paraventricular nuclei and supraoptic nuclei of the hypothalamus. The number of arginine–vasopressin-immunoreactive neurons in M2 receptor-knockout mice was significantly decreased in the supraoptic nuclei, but not in the paraventricular nuclei compared with wild-type mice. Plasma arginine–vasopressin level in M2 receptor-knockout mice was also significantly lower than in the wild-type mice. Urinary volume and frequency as well as water intake in M2 receptor-knockout mice were significantly higher than those in wild-type mice. The V2 vasopressin receptor expression in kidneys of M2 receptor-knockout mice was comparable with that of wild-type mice, and increased urination in M2 receptor-knockout mice was significantly decreased by administration of desmopressin, a specific V2 receptor agonist, suggesting that V2 receptors in the kidneys of M2 receptor-knockout mice are intact. These results suggest that M2 receptors promote arginine–vasopressin synthesis in the supraoptic nuclei and play a role in the regulation and maintenance of body fluid.

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Chemogenetic activation of endogenous arginine vasopressin exerts anorexigenic effects via central nesfatin-1/NucB2 pathway

The Journal of Physiological Sciences ◽

10.1186/s12576-021-00802-4 ◽

2021 ◽

Vol 71 (1) ◽

Author(s):

Kenya Sanada ◽

Mitsuhiro Yoshimura ◽

Naofumi Ikeda ◽

Kazuhiko Baba ◽

Haruki Nishimura ◽

...

Keyword(s):

Food Intake ◽

Water Intake ◽

Adult Male ◽

Arginine Vasopressin ◽

Neutralizing Antibody ◽

Circadian Rhythmicity ◽

Transgenic Rat ◽

Transgenic Rats ◽

Food And Water Intake ◽

Fos Expression

AbstractWe examined whether the chemogenetic activation of endogenous arginine vasopressin (AVP) affects central nesfatin-1/NucB2 neurons, using a transgenic rat line that was previously generated. Saline (1 mL/kg) or clozapine-N-oxide (CNO, 1 mg/mL/kg), an agonist for hM3Dq, was subcutaneously administered in adult male AVP-hM3Dq-mCherry transgenic rats (300–370 g). Food and water intake were significantly suppressed after subcutaneous (s.c.) injection of CNO, with aberrant circadian rhythmicity. The percentages of Fos expression in nesfatin-1/NucB2-immunoreactive neurons were significantly increased in the hypothalamus and brainstem at 120 min after s.c. injection of CNO. Suppressed food intake that was induced by chemogenetic activation of endogenous AVP was ablated after intracerebroventricularly administered nesfatin-1/NucB2-neutralizing antibody in comparison with vehicle, without any alteration of water intake nor circadian rhythmicity. These results suggest that chemogenetic activation of endogenous AVP affects, at least in part, central nesfatin-1/NucB2 neurons and may exert anorexigenic effects in the transgenic rats.

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