Base-labile 5'-OH protecting groups - A new approach in oligonucleotide synthesis

1990 ◽  
Vol 55 (s1) ◽  
pp. 197-200
Author(s):  
Helga Schirmeister ◽  
Wolfgang Pfleiderer
Keyword(s):  
Protecting Groups ◽  
Oligonucleotide Synthesis ◽  
New Approach

New coloured protecting groups in oligonucleotide synthesis cleavable by β-elimination

1993 ◽  
Vol 58 (s1) ◽  
pp. 163-166
Author(s):  
Markus Beier ◽  
Wolfgang Pfleiderer
Keyword(s):  
Protecting Groups ◽  
Oligonucleotide Synthesis

Coupling of Steroid O-(Carboxymethyl)oxime Derivatives with Single-Protected α,ω-Diaminoalkanes

1999 ◽  
Vol 64 (12) ◽  
pp. 2035-2043 ◽  
Author(s):  
Vladimír Pouzar ◽  
Ivan Černý ◽  
Pavel Drašar
Keyword(s):  
Trifluoroacetic Acid ◽  
Protecting Groups ◽  
Oxime Group ◽  
Amino Groups ◽  
New Approach ◽  
Terminal Amino ◽  
Oxime Derivatives

New approach to the synthesis of steroid oximes bearing O-substituents with terminal amino groups was described. The easily accessible steroid O-(carboxymethyl)oximes were reacted with single-protected Boc-α,ω-diaminoalkanes to give corresponding amide intermediates. From them the Boc protecting groups were cleaved with trifluoroacetic acid to afford the desired steroid derivatives with terminal amino groups. The procedure was succesfully tested on steroids with O-(carboxymethyl)oxime group in positions 7 and 17. The decomposition of target products was observed during deprotection of substituted 19-oximes.

ChemInform Abstract: Nucleotide Chemistry. Part 16. Amidine Protecting Groups for Oligonucleotide Synthesis.

1986 ◽  
Vol 17 (32) ◽  
Author(s):  
L. J. MCBRIDE ◽  
R. KIERZEK ◽  
S. L. BEAUCAGE ◽  
M. H. CARUTHERS
Keyword(s):  
Protecting Groups ◽  
Oligonucleotide Synthesis

Oligonucleotide Synthesis Involving Deprotection of Amidine-Type Protecting Groups for Nucleobases under Acidic Conditions

2010 ◽  
Vol 12 (11) ◽  
pp. 2496-2499 ◽  
Author(s):  
Akihiro Ohkubo ◽  
Yasukazu Kuwayama ◽  
Yudai Nishino ◽  
Hirosuke Tsunoda ◽  
Kohji Seio ◽  
...  
Keyword(s):  
Protecting Groups ◽  
Oligonucleotide Synthesis ◽  
Acidic Conditions

NPE-resin, a new approach to the solid-phase synthesis of protected peptides and oligonucleotides I : Synthesis of the supports and their application to oligonucleotide synthesis.

1991 ◽  
Vol 32 (11) ◽  
pp. 1511-1514 ◽  
Author(s):  
Ramon Eritja ◽  
Jordi Robles ◽  
Dolors Fernandez-Forner ◽  
Fernando Albericio ◽  
Ernest Giralt ◽  
...  
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Oligonucleotide Synthesis ◽  
New Approach ◽  
Phase Synthesis ◽  
Protected Peptides

scholarly journals Oligonucleotide synthesis using the 2-(levulinyloxymethyl)-5-nitrobenzoyl group for the 5'-position of nucleoside 3'-phosphoramidite derivatives.

1998 ◽  
Vol 45 (4) ◽  
pp. 949-976 ◽  
Author(s):  
K Kamaike ◽  
H Takahashi ◽  
K Morohoshi ◽  
N Kataoka ◽  
T Kakinuma ◽  
...  
Keyword(s):  
Comparative Study ◽  
Protecting Groups ◽  
Protecting Group ◽  
Oligonucleotide Synthesis ◽  
Amino Groups ◽  
Initiator Trna ◽  
15N Labeling

A comparative study on the utility of 2-(levulinyloxymethyl)-5-nitrobenzoyl (LMNBz) and 2-(levulinyloxymethyl)benzoyl (LMBz) protecting groups for the 5'-positions of nucleoside 3'-phosphoramidite derivatives in the oligonucleotide synthesis is presented in terms of the syntheses of TpTpT, TpTpTpT, and UpCpApGpUpUpGpG. In addition we describe the synthesis, using the LMNBz protecting group, of the CpCpA terminus triplet of tRNAs bearing exocyclic amino groups with 15N-labeling, and the trimer Gp[A*]pG containing 2'-O-(beta-D-ribofuranosyl)adenosine ([A*]), the latter of which is found at position 64 in the yeast initiator tRNA(Met).

SILYL PROTECTING GROUPS FOR OLIGONUCLEOTIDE SYNTHESIS REMOVED BY A ZnBr2 TREATMENT

2005 ◽  
Vol 24 (5-7) ◽  
pp. 1009-1013 ◽  
Author(s):  
Fernando Ferreira ◽  
François Morvan
Keyword(s):  
Protecting Groups ◽  
Oligonucleotide Synthesis

Novel Base-Labile Protecting Groups for 5′-Hydroxy Function in Solid-Phase Oligonucleotide Synthesis

2003 ◽  
Vol 22 (5-8) ◽  
pp. 1011-1015 ◽  
Author(s):  
Kazuo Kamaike ◽  
Takashi Namiki ◽  
Etsuko Kawashima
Keyword(s):  
Solid Phase ◽  
Protecting Groups ◽  
Oligonucleotide Synthesis

ChemInform Abstract: NPE-Resin, a New Approach to the Solid-Phase Synthesis of Protected Peptides and Oligonucleotides. Part 1. Synthesis of the Supports and Their Application to Oligonucleotide Synthesis.

ChemInform ◽  
2010 ◽  
Vol 23 (2) ◽  
pp. no-no
Author(s):  
R. ERITJA ◽  
J. ROBLES ◽  
D. FERNANDEZ-FORNER ◽  
F. ALBERICIO ◽  
E. GIRALT ◽  
...  
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Oligonucleotide Synthesis ◽  
New Approach ◽  
Phase Synthesis ◽  
Protected Peptides
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