Identification of 1-(3,4-Dihydroxyphenylazo)-2-hydroxynaphthalene as the Product of Oxidation of 1-Phenylazo-2-hydroxynaphthalene (Sudan I, Solvent Yellow 14) by Rat Liver Microsomes

1994 ◽  
Vol 59 (12) ◽  
pp. 2727-2733 ◽  
Author(s):  
Marie Stiborová ◽  
Befekadu Asfaw ◽  
Eva Frei ◽  
Heinz H. Schmeiser ◽  
Manfred Wiessler
Keyword(s):  
Rat Liver ◽  
Azo Dye ◽  
Liver Microsomes ◽  
Rat Liver Microsomes ◽  
Microsomal Cytochrome ◽  
Sudan I ◽  
Unknown Structure ◽  
Cytochrome P 450

The carcinogenic azo dye 1-phenylazo-2-hydroxynaphthalene (Sudan I, Solvent Yellow 14) is oxidized by rat liver microsomes to a number of azo-containing metabolites. One of the products of hitherto unknown structure has been shown to be identical with 1-(3,4-dihydroxyphenylazo)-2-hydroxynaphthalene. The identification of this product completed the pattern of major products of Sudan I oxidation by microsomal cytochrome P-450.

Interlaboratory comparison of total cytochrome P-450 and protein determinations in rat liver microsomes

1987 ◽  
Vol 61 (1) ◽  
pp. 27-33 ◽  
Author(s):  
Alphons A. J. J. L. Rutten ◽  
Hein E. Falke ◽  
Jan F. Catsburg ◽  
Randy Topp ◽  
Bas J. Blaauboer ◽  
...  
Keyword(s):  
Rat Liver ◽  
Interlaboratory Comparison ◽  
Liver Microsomes ◽  
Rat Liver Microsomes ◽  
Cytochrome P 450

Pituitary regulation of cytochrome P-450-mediated metabolism of steroids and xenobiotics in rat liver microsomes

1986 ◽  
Vol 7 (4) ◽  
pp. 575-582 ◽  
Author(s):  
Agneta Blanck ◽  
Anders Åström ◽  
Tiiu Hansson ◽  
Joseph W. De Pierre ◽  
Jan-Åke Gustafsson
Keyword(s):  
Rat Liver ◽  
Liver Microsomes ◽  
Rat Liver Microsomes ◽  
Cytochrome P 450
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