Safety, tolerability, pharmacokinetics, pharmacodynamics and efficacy of the monoclonal antibody ASK8007 blocking osteopontin in patients with rheumatoid arthritis: a randomised, placebo controlled, proof-of-concept study

M J H Boumans; J G A Houbiers; P Verschueren; H Ishikura; R Westhovens; E Brouwer; B Rojkovich; S Kelly; M den Adel; J Isaacs; H Jacobs; J Gomez-Reino; G M Holtkamp; A Hastings; D M Gerlag; P P Tak

doi:10.1136/annrheumdis-2011-200298

Safety, tolerability, pharmacokinetics, pharmacodynamics and efficacy of the monoclonal antibody ASK8007 blocking osteopontin in patients with rheumatoid arthritis: a randomised, placebo controlled, proof-of-concept study

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2011-200298 ◽

2011 ◽

Vol 71 (2) ◽

pp. 180-185 ◽

Cited By ~ 24

Author(s):

M J H Boumans ◽

J G A Houbiers ◽

P Verschueren ◽

H Ishikura ◽

R Westhovens ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Monoclonal Antibody ◽

Proof Of Concept ◽

Concept Study

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Faculty Opinions recommendation of LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I randomized, double-blind, placebo-controlled, proof-of-concept study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.724435768.793505748 ◽

2015 ◽

Author(s):

Vijay Kuchroo

Keyword(s):

Rheumatoid Arthritis ◽

Monoclonal Antibody ◽

Phase I ◽

Interleukin 17 ◽

Proof Of Concept ◽

Double Blind ◽

Double Blind Placebo ◽

Concept Study

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The human anti-IL-1β monoclonal antibody ACZ885 is effective in joint inflammation models in mice and in a proof-of-concept study in patients with rheumatoid arthritis

Arthritis Research & Therapy ◽

10.1186/ar2438 ◽

2008 ◽

Vol 10 (3) ◽

pp. R67 ◽

Cited By ~ 115

Author(s):

Rieke Alten ◽

Hermann Gram ◽

Leo A Joosten ◽

Wim Berg ◽

Joachim Sieper ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Monoclonal Antibody ◽

Joint Inflammation ◽

Proof Of Concept ◽

Concept Study

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LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I randomized, double-blind, placebo-controlled, proof-of-concept study

Arthritis & Rheumatism ◽

10.1002/art.27334 ◽

2010 ◽

Vol 62 (4) ◽

pp. 929-939 ◽

Cited By ~ 341

Author(s):

M. C. Genovese ◽

F. Van den Bosch ◽

S. A. Roberson ◽

S. Bojin ◽

I. M. Biagini ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Monoclonal Antibody ◽

Phase I ◽

Interleukin 17 ◽

Proof Of Concept ◽

Double Blind ◽

Double Blind Placebo ◽

Concept Study

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Design considerations and analysis planning of a phase 2a proof of concept study in rheumatoid arthritis in the presence of possible non-monotonicity

BMC Medical Research Methodology ◽

10.1186/s12874-017-0416-3 ◽

2017 ◽

Vol 17 (1) ◽

Cited By ~ 3

Author(s):

Feng Liu ◽

Stephen J. Walters ◽

Steven A. Julious

Keyword(s):

Rheumatoid Arthritis ◽

Proof Of Concept ◽

Concept Study ◽

Design Considerations

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Sirukumab, a human anti-interleukin-6 monoclonal antibody: a randomised, 2-part (proof-of-concept and dose-finding), phase II study in patients with active rheumatoid arthritis despite methotrexate therapy

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2013-205137 ◽

2014 ◽

Vol 73 (9) ◽

pp. 1616-1625 ◽

Cited By ~ 110

Author(s):

Josef S Smolen ◽

Michael E Weinblatt ◽

Shihong Sheng ◽

Yanli Zhuang ◽

Benjamin Hsu

Keyword(s):

Rheumatoid Arthritis ◽

Monoclonal Antibody ◽

Phase Ii ◽

Interleukin 6 ◽

Active Rheumatoid Arthritis ◽

Phase Ii Study ◽

Methotrexate Therapy ◽

Dose Finding ◽

Proof Of Concept

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AB0758 Performance of a therapeutic attempt with oral prednisolone in patients with rheumatoid arthritis and hand osteoarthritis – a proof of concept study

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2013-eular.3080 ◽

2013 ◽

Vol 72 (Suppl 3) ◽

pp. A1020.3-A1021

Author(s):

U. Kiltz ◽

C. von Zabern ◽

F. Heldmann ◽

M. van Werde ◽

B. Mintrop ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Oral Prednisolone ◽

Hand Osteoarthritis ◽

Proof Of Concept ◽

Concept Study

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SAT0558 New Generation Translocator Protein Pet Tracers To Image Arthritis by Macrophage Targeting in Rheumatoid Arthritis Patients: A Proof of Concept Study:

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2016-eular.4215 ◽

2016 ◽

Vol 75 (Suppl 2) ◽

pp. 871.2-871

Author(s):

S. Bruijnen ◽

Y. Gent ◽

M. Huisman ◽

A. Windhorst ◽

M. Kassiou ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Translocator Protein ◽

Proof Of Concept ◽

Pet Tracers ◽

Concept Study ◽

Macrophage Targeting ◽

New Generation

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Using a Discrete-Choice Experiment in a Decision Aid to Nudge Patients Towards Value-Concordant Treatment Choices in Rheumatoid Arthritis: A Proof-of-Concept Study

Patient Preference and Adherence ◽

10.2147/ppa.s221897 ◽

2020 ◽

Vol Volume 14 ◽

pp. 829-838

Author(s):

Glen S Hazlewood ◽

Deborah A Marshall ◽

Claire EH Barber ◽

Linda C Li ◽

Cheryl Barnabe ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Discrete Choice Experiment ◽

Discrete Choice ◽

Choice Experiment ◽

Decision Aid ◽

Proof Of Concept ◽

Treatment Choices ◽

Concept Study

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Faculty of 1000 evaluation for A Randomized Controlled Trial of an Internal Family Systems-based Psychotherapeutic Intervention on Outcomes in Rheumatoid Arthritis: A Proof-of-Concept Study.

F1000 - Post-publication peer review of the biomedical literature ◽

10.3410/f.718080056.793484707 ◽

2013 ◽

Author(s):

Joel Block

Keyword(s):

Rheumatoid Arthritis ◽

Randomized Controlled Trial ◽

Family Systems ◽

Controlled Trial ◽

Proof Of Concept ◽

Psychotherapeutic Intervention ◽

Concept Study ◽

Randomized Controlled ◽

Internal Family Systems

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Targeting interleukin-15 in patients with rheumatoid arthritis: A proof-of-concept study

Arthritis & Rheumatism ◽

10.1002/art.21249 ◽

2005 ◽

Vol 52 (9) ◽

pp. 2686-2692 ◽

Cited By ~ 186

Author(s):

Bo Baslund ◽

Niels Tvede ◽

Bente Danneskiold-Samsoe ◽

Per Larsson ◽

Gabriel Panayi ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Proof Of Concept ◽

Concept Study ◽

Interleukin 15

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