scholarly journals Upregulation of insulin-like growth factor I gene expression in the lesions of osteoarthritic human articular cartilage.

1992 ◽  
Vol 51 (4) ◽  
pp. 440-447 ◽  
Author(s):  
J F Middleton ◽  
J A Tyler
Keyword(s):  
Gene Expression ◽  
Articular Cartilage ◽  
Growth Factor ◽  
Human Articular Cartilage ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I ◽  
I Gene

Insulin-like growth factor I gene expression by primary cultures of ovarian cells: insulin and dexamethasone dependence.

Endocrinology ◽  
1993 ◽  
Vol 132 (6) ◽  
pp. 2703-2708 ◽  
Author(s):  
L F Botero ◽  
C T Roberts ◽  
D LeRoith ◽  
E Y Adashi ◽  
E R Hernandez
Keyword(s):  
Gene Expression ◽  
Growth Factor ◽  
Primary Cultures ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Ovarian Cells ◽  
Growth Factor I ◽  
I Gene

Ovarian and hepatic insulin-like growth factor-I gene expression and associated metabolic responses in prepubertal gilts subjected to feed restriction and refeeding

1993 ◽  
Vol 139 (1) ◽  
pp. 143-152 ◽  
Author(s):  
S. T. Charlton ◽  
J. R. Cosgrove ◽  
D. R. Glimm ◽  
G. R. Foxcroft
Keyword(s):  
Gene Expression ◽  
Growth Factor ◽  
Follicular Fluid ◽  
Feed Restriction ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Igf I ◽  
Growth Factor I ◽  
Plasma Gh ◽  
I Gene

ABSTRACT The effects of feed restriction and refeeding on ovarian and hepatic insulin-like growth factor-I (IGF-I) gene expression, systemic and ovarian IGF-I concentrations and on associated metabolic changes were measured in prepubertal gilts. Eleven pairs of littermate gilts (70·7 ± 4·7 kg) were placed on a maintenance level of feeding for 7 days (days 1–7). On day 8, littermates were either fed at a maintenance level of energy or fed to appetite for a further 6 days. Blood samples were taken on day 13 (07.00–16.00 h) to determine plasma insulin and IGF-I, and on day 14 (02.00–06.00 h) to determine plasma GH levels. Following slaughter on day 14, one ovary from each animal was retained to measure follicular fluid IGF-I and oestradiol concentrations. The remaining ovary and a sample of liver were retained for IGF-I mRNA analysis using a ribonuclease protection assay. Six days of refeeding significantly increased plasma IGF-I (P<0·005) and basal insulin (P<0·05) but there was no effect on plasma GH. Ovarian follicular volume and diameter were significantly larger after refeeding (P<0·05), with no effect on follicular fluid oestradiol concentrations. Mean follicular fluid IGF-I concentrations were unaffected by treatment. However, the relationships between individual follicular IGF-I concentrations, absolute follicular fluid IGF-I contents and follicle volume were affected by feeding level (P<0·05). Regression analysis of the same data also revealed that at this stage of maturity, small follicles had greater follicular fluid concentrations of IGF-I than larger follicles. Refeeding increased the amount of IGF-I mRNA in hepatic but not ovarian tissue. We conclude that there is differential regulation of the IGF-I gene in porcine hepatic and ovarian tissues, and that ovarian factors other than, or as well as, IGF-I are involved in the regulation of ovarian responses to refeeding. Journal of Endocrinology (1993) 139, 143–152

scholarly journals Regulation of insulin-like growth factor I gene expression by growth hormone.

1986 ◽  
Vol 83 (24) ◽  
pp. 9343-9347 ◽  
Author(s):  
L. S. Mathews ◽  
G. Norstedt ◽  
R. D. Palmiter
Keyword(s):  
Gene Expression ◽  
Growth Hormone ◽  
Growth Factor ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I ◽  
I Gene
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