scholarly journals Case of autoimmune polyglandular syndrome type 2: how we uncovered the diagnosis

2019 ◽  
Vol 12 (2) ◽  
pp. e227187
Author(s):  
Akhila Arya P V ◽  
Jayesh Kumar ◽  
Dileep Unnikrishnan ◽  
Rishi Raj
Keyword(s):  
Hormone Replacement ◽  
Final Diagnosis ◽  
Syndrome Type ◽  
Autoimmune Polyglandular Syndrome ◽  
Autoimmune Polyglandular Syndrome Type ◽  
Loss Of Appetite ◽  
Physical Findings ◽  
Work Up

A 24-year-old man with no significant medical history presented to the medical clinic with vomiting and giddiness for 2 days, loss of appetite for 1 month and progressive fatigability for the preceding 4 months. On examination, he was found to be hypotensive and was admitted to the hospital for work-up. Considering his abnormal labs and physical findings, he was worked up and was diagnosed with primary adrenal insufficiency. On further work-up for the aetiology of his Addison’s disease, he was found to have concurrent autoimmune thyroiditis and vitiligo. A final diagnosis of autoimmune polyglandular syndrome type 2 was made. The patient was started on hormone replacement therapy and reported improvement of symptoms on 3-month follow-up visit.

scholarly journals Autoimmune polyglandular syndrome, type 2 associated with myasthenia gravis

2012 ◽  
Vol 69 (4) ◽  
pp. 358-362 ◽  
Author(s):  
Radoslav Pejin ◽  
Edita Stokic ◽  
Mile Novkovic ◽  
Sofija Banic-Horvat ◽  
Milan Cvijanovic
Keyword(s):  
Case Report ◽  
Myasthenia Gravis ◽  
Adrenal Insufficiency ◽  
Muscle Weakness ◽  
Hormone Replacement ◽  
Primary Hypothyroidism ◽  
Syndrome Type ◽  
Autoimmune Polyglandular Syndrome ◽  
Autoimmune Polyglandular Syndrome Type

Introduction. Autoimmune polyglandular syndrome type 2 is defined as adrenal insufficiency associated with autoimmune primary hypothyroidism and/or with autoimmune type 1 diabetes mellitus, but very rare with myasthenia gravis. Case report. We presented a case of an autoimmune polyglandular syndrome, type 2 associated with myasthenia gravis. A 49-year-old female with symptoms of muscle weakness and low serum levels of cortisol and aldosterone was already diagnosed with primary adrenal insufficiency. Primary hypothyroidism was identified with low values of free thyroxine 4 (FT4) and raised values of thyroidstumulating hormone (TSH). The immune system as a cause of hypothyroidism was confirmed by the presence of thyroid antibodies to peroxidase and TSH receptors. Myasthenia gravis was diagnosed on the basis of a typical clinical feature, positive diagnostic tests and an increased titre of antibodies against the acetylcholine receptors. It was not possible to confirm the immune nature of adrenal insufficiency by the presence of antibodies to 21- hydroxylase. The normal morphological finding of the adrenal glands was an indirect confirmation of the condition as well as the absence of other diseases that might have led to adrenal insufficiency and low levels of both serum cortisol and aldosterone. Hormone replacement therapy, anticholinergic therapy and corticosteroid therapy for myasthenia gravis improved the patient?s general state of health and muscle weakness. Conclusion. This case report indicates a need to examine each patient with an autoimmune disease carefully as this condition may be associated with another autoimmune diseases.

scholarly journals Autoimmune Polyglandular Syndrome Type 2 (APS-2) in a 70-Year-Old Woman: A Case Report

2019 ◽  
Vol 27 (124) ◽  
pp. 47-51
Author(s):  
Shahin Besharati ◽  
Pouria Tavakkolian ◽  
Roghayeh Borji ◽  
◽  
◽  
...  
Keyword(s):  
Case Report ◽  
Syndrome Type ◽  
Autoimmune Polyglandular Syndrome ◽  
Autoimmune Polyglandular Syndrome Type

President John F Kennedy’s medical history: coeliac disease and autoimmune polyglandular syndrome type 2

2020 ◽  
Vol 96 (1139) ◽  
pp. 543-549
Author(s):  
Donatella Macchia ◽  
Donatella Lippi ◽  
Raffaella Bianucci ◽  
Simon Donell
Keyword(s):  
Coeliac Disease ◽  
Medical History ◽  
Gastrointestinal Symptoms ◽  
Pain Syndrome ◽  
Syndrome Type ◽  
Autoimmune Polyglandular Syndrome ◽  
History Of ◽  
Autoimmune Polyglandular Syndrome Type ◽  
Back Problem

President John F. Kennedy (JFK) had a complex medical history that is now thought to be an autoimmune polyglandular syndrome type 2 with Addison’s disease and hypothyroidism. He also had gastrointestinal symptoms from adolescence, which now fit well with coeliac disease. In addition, he had a chronic back problem, which contributed to a chronic pain syndrome. This review looks at JFK’s various diseases and focusses on the history of coeliac disease, as well as its presentation. JFK’s Irish ancestry supports the hypothesis of a coeliac disease started early in his youth.

scholarly journals Autoimmune Polyglandular Syndrome Type 2: A Rare Condition in Childhood

2015 ◽  
Vol 7 (1) ◽  
pp. 80-82 ◽  
Author(s):  
Heves Kırmızıbekmez ◽  
Rahime Gül Yeşiltepe Mutlu ◽  
Nafiye Demirkıran Urgancı ◽  
Ayşe Öner
Keyword(s):  
Rare Condition ◽  
Syndrome Type ◽  
Autoimmune Polyglandular Syndrome ◽  
Autoimmune Polyglandular Syndrome Type

scholarly journals Precocious presentation of autoimmune polyglandular syndrome type 2 associated with an AIRE mutation

HORMONES ◽  
2014 ◽  
Author(s):  
Eduarda Resende ◽  
Gemma Novoa Gόmez ◽  
Marta Nascimento ◽  
Lourdes Loidi ◽  
Rebeca Saborido Fiaño ◽  
...  
Keyword(s):  
Syndrome Type ◽  
Autoimmune Polyglandular Syndrome ◽  
Autoimmune Polyglandular Syndrome Type
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