Background/Aim. Age-related macular degeneration (AMD) is a leading cause of
the loss of central visual acuity in population older than 70 years. We can
distinguish wet and dry form of AMD. The aim of the study was to present our
early results in treatment of the wet (neovascular) form of AMD with
intravitreal administration of bevacizumab. Methods. The study included 39
patients. Each patient underwent a complete ophthalmological examination,
fluorescein angiography (FA) and optical coherence tomography (OCT). All the
patients received 1.25 mg of intravitreal bevacizumab (0.05 mL of commercial
phial of Avastin?). The total of three doses was given with a one-month
interval between doses. Results. Among 39 patients, 24 were women and 15 men.
The average best corrected visual acuity (BCVA) was improved from 0.09 before
the therapy to 0.24 after the administration of all the three doses of
bevacizumab (p < 0.001). The average central macular thickness (CMT) measured
by OCT was improved from 474 ?m in the beginning to 341 ?m after the
administration of all the three doses of the drug (p < 0.001). There were no
side effects. Conclusions. Our short-term experience indicates that
intravitreal administration of three doses of bevacizumab in one-month
intervals between the doses leads to a significant reduction of macular edema
and improvement of BCVA in patients with neovascular AMD.