Comparing the ganglion cell complex and retinal nerve fibre layer measurements by Fourier domain OCT to detect glaucoma in high myopia

Aim.To evaluate the possible structural and functional changes in the retinal nerve fibre layer (RNFL) and the ganglion cell complex (GCC) of chronic smokers and compare them with those of passive healthy smokers using spectral domain optical coherence tomography (SD-OCT) and pattern electroretinogram (PERG).Materials and Methods. We include 80 active chronic smokers and 80 age- and sex-matched healthy passive smokers. After a full ophthalmological examination, SD-OCT and PERG were tested for all participants. Urinary levels of cotinine and creatinine with subsequent calculation of the cotinine creatinine ratio (CCR).Results. Inferior and superior quadrants of RNFL were thinner in group I, but nasal and temporal quadrants did not show significant difference between the groups. There were no significant differences of GCC values between the two groups. There was no significant difference of PERG-P50 amplitude and latency; however, PERG-N95 showed significant difference between the two groups. Multiple regression analyses demonstrated that the number of cigarettes/day, urinary cotinine, and PERG-N95 amplitude are the most important determinants for both superior and inferior RNFL thicknesses.Conclusion. RNFL thickness decreases in chronic, healthy, heavy cigarette smokers, and this thinning is related to the number of cigarettes/day, urinary cotinine, and PERG-N95 latency and amplitude.

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Evaluation of the retinal nerve fibre layer and ganglion cell complex thickness in pituitary macroadenomas without optic chiasmal compression

Eye ◽

10.1038/eye.2015.35 ◽

2015 ◽

Vol 29 (6) ◽

pp. 797-802 ◽

Cited By ~ 20

Author(s):

G Cennamo ◽

R S Auriemma ◽

D Cardone ◽

L F S Grasso ◽

N Velotti ◽

...

Keyword(s):

Ganglion Cell ◽

Nerve Fibre ◽

Retinal Nerve Fibre Layer ◽

Cell Complex ◽

Ganglion Cell Complex ◽

Chiasmal Compression ◽

Fibre Layer ◽

Nerve Fibre Layer ◽

Pituitary Macroadenomas

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Retinal nerve fibre layer and ganglion cell complex thickness in patients with keratoconus

African Vision and Eye Health ◽

10.4102/aveh.v77i1.417 ◽

2018 ◽

Vol 77 (1) ◽

Author(s):

Prianka Cuppusamy ◽

Nokwanda Makhanya ◽

Mbekezeli Methula ◽

Kausar M. Essop ◽

Duduzile Sibisi ◽

...

Keyword(s):

Ganglion Cell ◽

Nerve Fibre ◽

Retinal Nerve Fibre Layer ◽

Cell Complex ◽

Control Group ◽

Ganglion Cell Complex ◽

Equal Distribution ◽

Fibre Layer ◽

The Mean ◽

Nerve Fibre Layer

Background: Keratoconus, a corneal ectasia, is associated with corneal thinning and altered optical media. Consequently, assessment of the visual field, optic nerve head and intraocular pressure measurements may be challenging in patients with keratoconus. Few studies have investigated posterior segment variables including the retinal nerve fibre layer (RNFL) and ganglion cell complex (GCC) thickness in patients with keratoconus.Aim: To investigate RNFL and GCC thickness in patients with keratoconus.Methods: A comparative quantitative research design was used. The sample consisted of 56 participants (28 with mild, moderate or severe keratoconus, and 28 controls) who accessed the optometry clinic at the University of KwaZulu-Natal. There was an equal distribution of male (n = 14) and female (n = 14) participants in the keratoconus and control groups. Most participants were black (n = 34) or Indian (n = 18). Corneal power and refractive error were assessed with the Oculus Keratograph and subjective refraction respectively. The iVue-100 optical coherence topography device was used to measure RNFL and GCC thickness. Data were analysed by descriptive and inferential statistics.Results: The mean global RNFL thickness was slightly higher in the control group than the keratoconus group for the right (106 µm vs. 99 µm) and left (103 µm vs. 98 µm) eyes but these differences were not significant (p ≥ 0.057). For all RNFL quadrants, slightly lower mean RNFL measurements were found in the keratoconus group. The mean GCC thicknesses were marginally higher (3 µm – 6 µm) in the control group.Conclusion: The RNFL and GCC thickness differences between patients with keratoconus and controls are not clinically significant. Therefore, abnormally reduced RNFL and GCC thickness measurements in patients with keratoconus warrant further investigation for other pathologies specifically glaucoma.

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